The responses of creatine kinase and lactate dehydrogenase to acute eccentric activity after saffron supplementation in healthy man
Paper Details
The responses of creatine kinase and lactate dehydrogenase to acute eccentric activity after saffron supplementation in healthy man
Abstract
The purpose of present study was to investigate responses of creatine kinase and lactate dehydrogenase to acute eccentric activity after saffron and vitamin C supplementation in healthy man. For this purpose 21 subjects attended in this study, they were assigned randomly to three separate group: saffron group, vitamin C group and placebo group and during fourteen days, each group receive their supplement in form of capsule. After fourteen days supplementation subjects were running with their 70% of their VO2max on treadmill with 10 percent gradient for forty five minutes. Five ml Blood samples were taken from antecubital vein before supplementation, before exercise, immediately after exercise and 1h recovery after exercise. Data Analyzes of between group comparison using repeated measure ANOVA for CK and LDH in done. Results show significant decrease of CK immediately after exercise but LDH didn’t show significant changes by saffron supplementation. In general it seems that saffron supplementation during eccentric contraction activity decrease enzymatic activity of CK in comparison with control group.
Abe K, Sugiura M, Ymaguchi S, Shoyama Y, Saito H. 1999. Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo. Brain Research 851, 287–9. http://dx.doi.org/10.1016/S0006-8993(99)02174-5
Abdullaev FJ. 1993. Biological effects of saffron. Biofactors 4, 83–6.
Armstrong RB. 1990. Initial events in exercise-induced muscular injury. Medicine and Science in Sports and Exercise 22(4), 429-435.
Asdaq SMB, Inamdar MN. 2010. Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Applied biochemistry and biotechnology 162(2), 358-372. http://dx.doi.org/10.1007/s12010-009-8740-7
Assimopoulou AN, Sinakos Z, Papageorgiou VP. 2005. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytotherapy Researchearch 19, 997–1000. http://dx.doi.org/10.1002/ptr.1749
Cervellin G, Comelli I, Lippi G. 2010. Historical background clinical, diagnostic and therapeutic features. Clinical Chemistry and Laboratory Medicine 48.(6) , 749 – 75.
Chen Y, Zhang H, Tian X, Zhao C, Cai L, Liu Y, Jia L, Yin HX, Chen C. 2008. Antioxidant potential of crocins and ethanol extracts of Gardenia jasminoides ELLIS and Crocus sativus L.: A relationship investigation between antioxidant activity and crocin contents. Food Chemistry 109, 484-92. http://dx.doi.org/10.1016/j.foodchem.2007.09.080
Choung BY, Byun SJ, Suh JG, Kim TY. 2004. Extracellular superoxide dismutase tissue distribution and the patterns of superoxide dismutase mRNA expression following ultraviolet irradiation on mouse skin. Experimental Dermatology 13(11), 691-9. http://dx.doi.org/10.1111/j.0906-6705.2004.00209.x
Goldfarb AH, Bloomer RJ, et al. 2005. Combined antioxidant treatment effects on blood oxidative stress after eccentric exercise. Medicine and science in sports and exercise 37(2), 234. http://dx.doi.org/10.1249/01.MSS.0000152887.8778 5.BE
Groussard C, Rannou-Bekono F, Machefer G, Chevanne M, Vincent S, Sergent O, et al. 2003. Changes in blood lipid peroxidation markers and antioxidants after a single sprint anaerobic exercise. European Journal of Applied Physiology 89(1), 14-20. http://dx.doi.org/10.1007/s00421-002-0767-1
Hosseinzadeh H, Karimi Gh, Niapoor M. 2004. Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice. Acta Horticulturae 650, 435–45.
Hosseinzadeh H, Khosravan V. 2005. Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Archives of Iranian medicine 5, 44–7.
Hosseinzadeh H, Modaghegh MH. 2009. Crocus sativus L.(Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evidence-Based Complementary and Alternative Medicine 6(3), 343-350. http://dx.doi.org/10.1093/ecam/nem125
Hosseinzadeh H, Modaghegh MH, Saffari Z. 2009. Crocus Sativus L. (Saffron) Extract and its Active Constituents (Crocin and Safranal) on Ischemia-Reperfusion in Rat Skeletal Muscle. Evidence-based Complementary and Alternative Medicine 6(3), 343–350. http://dx.doi.org/10.1093/ecam/nem125
Hosseinzadeh H, Sadeghnia HR. 2005. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. The Journal of Pharmaceutical Sciences 8(3), 387-393.
Hosseinzadeh H, Younesi HM. 2002. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacology 2, 1–8.
Melin B, Bourdon L, Jimenez C, Charpenet A, Bernard O. 1997, Plasma myo sin and creatine kinase time-course after a concentric-eccentric field exercise. Archives of Physiology and Biochemistry 105, 27-31. http://dx.doi.org/10.1076/apab.105.1.27.13149
Nair SC, Kurumboor S. 1995. Saffron chemoprevention in biology and medicine: a review. Cancer Biotherapy & Radiopharmaceuticals 10(4), 257-264. http://dx.doi.org/10.1089/cbr.1995.10.257
Newham DJ, Jones DA, Edwards RH. 1986. Plasma creatine kinase changes after eccentric and concentric contractions. Muscle and Nerve 9,59-63. http://dx.doi.org/10.1002/mus.880090109
Premkumar K, Abraham SK, Santhiya ST, Ramesh A. 2003. Protective effects of saffron (Crocus sativus L.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytotherapy Research 17,614–17 http://dx.doi.org/10.1002/ptr.1209
Ríos JL, Recio MC, Giner RM, Máňez S. 1996. An update review of saffron and its active constituents. Phytotherapy Research 10,189–93. http://dx.doi.org/10.1002/(SICI)1099-1573(199605)10:3<189::AID-PTR754>3.0.CO;2-C
Saxton JM, Donnelly AE. 1995. Light concentric exercise during recovery from exercise-induced muscle damage. International Journal of Sports Medicine 16,347-351. http://dx.doi.org/10.1055/s-2007-973018
Sinha S, Ray US, Saha M, Singh SN, Tomar OS. 2009. Antioxidant and redox status after maximal aerobic exercise athigh altitude in acclimatized lowlanders and native highlanders. European Journal of Applied Physiology 106, 807-14. http://dx.doi.org/10.1007/s00421-009-1082-x
Verma SK, Bordia A. 1998, Antioxidant property of saffron in man. Indian Journal of Medicine Science 52, 205–7.
Mohammad Musaie, Mohammad Ali Azarbayjani, Maghsoud Peeri (2013), The responses of creatine kinase and lactate dehydrogenase to acute eccentric activity after saffron supplementation in healthy man; IJB, V3, N8, August, P319-324
https://innspub.net/the-responses-of-creatine-kinase-and-lactate-dehydrogenase-to-acute-eccentric-activity-after-saffron-supplementation-in-healthy-man/
Copyright © 2013
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0