home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Evaluation of antihyperlipidemic activity of Himalrandia tetrasperma in Triton WR-1339 (Tyloxapol) induced hyperlipidemia in rat model

Paper Details

Research Paper 01/02/2020
Views (426) Download (16)
current_issue_feature_image
publication_file

Evaluation of antihyperlipidemic activity of Himalrandia tetrasperma in Triton WR-1339 (Tyloxapol) induced hyperlipidemia in rat model

Yaqoob ur Rehman, Bashir Ahmad, Mushtaq Ahmad, Saad Ahmad Khan, Muhammad Idrees, Shafaatullah, Farah Gul
Int. J. Biosci.16( 2), 535-540, February 2020.
Certificate: IJB 2020 [Generate Certificate]
Key: AntihyperlipidemicHimalrandia tetraspermalipid profileTriton WR-1339 (Tyloxapol)

Abstract

Pants are used by human beings since prehistoric times for therapeutic purposes. Statistical records revealed that more than 250,000 higher plants are found on the globe. Among these a large number are practicing for the management of various pathological disorders. Himalrandia tetrasperma (H. tetrasperma) also carries immense importance medicinal properties such as abortifacient, anthelmintic, antidysentric, antidiabetic, antifungal and antibacterial. The aim of the current study was to evaluate the antihyperlipidemic activity of Methanolic extract of Himalrandia tetrasperma (MEHT) in Tyloxapol (Triton WR-1339) induced hyperlipidemia in rat model. The administration of Tyloxapol prominently increased the level of lipid parameters such as total cholesterol (TC), triglycerides (TG), Low density lipoprotein (LDL), Very low density lipoprotein high density lipoprotein (VLDL) and reduced the level of high density lipoprotein (HDL). Treatment with H. tetrasperma caused reduction in the level of TC, TG, LDL and VLDL while increase in the level of HDL in a dose reliant manner. It is concluded that in Tyloxapol induced hyperlipidemia, MEHT decreases the levels of TC, TG, LDL, VLDL and increases the level of HDL and could be used be used to develop a natural drug to treat the hyperlipidemia.

VIEWS 17
Cover PDF

Ajaib M, Latif M, Kamran SH, Khan KM, Perveen S, Shah S and Kareen A. 2016. Comparative Anti-Diabetic Evaluation of Different Parts of Himalrandia tetrasperma in Alloxan Induced Diabetic in Mice. Journal of Chemimical Society of Pakistan 38, 313-317.

Avogaro A, de Kreutzenberg SV. 2005. Mechanisms of endothelial dysfunction in obesity. Clinica Chimica Acta 360, 9-26.

Banerjee A, Vaghasiya R, Shrivastava N, Padh H, Nivsarkar M. 2006. Anti-hyperlipidemic effect of carcia papaya L in sprague dawley rats. Nigerian Journal of Natural Products and Medicine 10, 69-72.

Friedman M, Byers SO. 1957. Mechanism underlying hypercholesteremia induced by Triton WR-1339. American Journal of Physiology-Legacy Content 190, 439-445.

Garattini S, Paoletti P, Paoletti R. 1959. The effect of triton and diphenylylethylacetic acid on cholesterol and fatty acid biosynthesis in isolated perfused liver. Cellular and Molecular Life Sciences 15, 33-34.

Holmes WL. 1964. Drugs affecting lipid synthesis. Medicinal Chemistry, Elsevier 2, 131-184.

Idrees M, Ahmad B, Ahmad K, Bashir S, Ali A, Aman K. 2018. Anti-tuberculous, phytotoxic and insecticidal activities of secondary metabolites obtained from aspergillus and penicillium species isolated from soil. JPMA 68.

Kellner A, Correll JW, Ladd AT. 1951. Sustained hyperlipemia induced in rabbits by means of intravenously injected surface-active agents. Journal of Experimental Medicine 93, 373-383.

Khanna A, Rizvi F, Chander R. 2002. Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. Journal of Ethnopharmacology 82, 19-22.

Lamarche B, St-Pierre AC, Ruel IL, Cantin B, Dagenais GR, Després JP. 2001. A prospective, population-based study of low density lipoprotein particle size as a risk factor for ischemic heart disease in men. The Canadian journal of cardiology 17, 859-865.

Mukherjee PK. 2003. Plant products with hypocholesterolemic potentials. Advances in food and nutrition research 47, 278-338.

Naderali EK. 2009. Obesity and cardiovascular dysfunction: A role for resveratrol? Obesity research & clinical practice 3, 45-52.

Otway S, Robinson D. 1967. The effect of a non‐ionic detergent (Triton WR 1339) on the removal of triglyceride fatty acids from the blood of the rat. The Journal of physiology 190, 309-319.

Pandit K, Karmarkar S, Bhagwat A. 2011. Evaluation of antihyperlipidemic activity of Ficus hispida linn leaves in triton wr-1339 (tyloxapol) induced hyperlipidemia in mice. Int. J. Pharm. Sci 5, 188-191.

Pascot A, Lemieux I, Prud’homme D, Tremblay A, Nadeau A, Couillard C, Bergeron J, Lamarche B, Després JP. 2001. Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. Journal of lipid research 42, 2007-2014.

Raj DA, Malarvili T, Velavan S. 2014. Evaluation of hypolipidemic activity of Betula alnoides bark on triton WR-1339 induced hyperlipidemia in albino rats. Am. J. Pharm. Sci 1, 1-5.

Rajani G, Ashok P. 2009. In vitro antioxidant and antihyperlipidemic activities of Bauhinia variegata Linn. Indian journal of pharmacology 41, 227.

Salman SM, Khan SB, Ali S, Shahwar De, Siddique M, Afridi ZK, Lutfullah G. 2015. Himalrandia tetrasperma, ethanolic extracts preliminary phytochemical analysis, antibacterial and antifungal activities. J. Bio. & Env. Sci 7, 100-109.

Schurr P, Schultz J, Parkinson TM. 1972. Triton‐induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs. Lipids 7, 68-74.

Speight TM, Avery GS, Eds. 1987. Drug treatment Principles and Practice of clinical Pharmacology and therapeutics.

Tamasi G, Borsy J, Patthy A. 1968. Comparison of the antilipemic effect of nicotinic acid (NA) and 3-methylpyrazole-5-carboxylic acid (MPC) in rats. Biochemical pharmacology 17, 1789-1794.

Wilson PW, Abbott RD, Castelli WP. 1988. High density lipoprotein cholesterol and mortality. The Framingham Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology 8, 737-741.

Submit Manuscript