Evaluation of antihyperlipidemic activity of Himalrandia tetrasperma in Triton WR-1339 (Tyloxapol) induced hyperlipidemia in rat model

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Evaluation of antihyperlipidemic activity of Himalrandia tetrasperma in Triton WR-1339 (Tyloxapol) induced hyperlipidemia in rat model

Yaqoob ur Rehman, Bashir Ahmad, Mushtaq Ahmad, Saad Ahmad Khan, Muhammad Idrees, Shafaatullah, Farah Gul
Int. J. Biosci.16( 2), 535-540, February 2020.
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Pants are used by human beings since prehistoric times for therapeutic purposes. Statistical records revealed that more than 250,000 higher plants are found on the globe. Among these a large number are practicing for the management of various pathological disorders. Himalrandia tetrasperma (H. tetrasperma) also carries immense importance medicinal properties such as abortifacient, anthelmintic, antidysentric, antidiabetic, antifungal and antibacterial. The aim of the current study was to evaluate the antihyperlipidemic activity of Methanolic extract of Himalrandia tetrasperma (MEHT) in Tyloxapol (Triton WR-1339) induced hyperlipidemia in rat model. The administration of Tyloxapol prominently increased the level of lipid parameters such as total cholesterol (TC), triglycerides (TG), Low density lipoprotein (LDL), Very low density lipoprotein high density lipoprotein (VLDL) and reduced the level of high density lipoprotein (HDL). Treatment with H. tetrasperma caused reduction in the level of TC, TG, LDL and VLDL while increase in the level of HDL in a dose reliant manner. It is concluded that in Tyloxapol induced hyperlipidemia, MEHT decreases the levels of TC, TG, LDL, VLDL and increases the level of HDL and could be used be used to develop a natural drug to treat the hyperlipidemia.


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