Formulation of Multi-Functional Nanoparticles for Magnetic Tumour Targeting and their Biomedical Applications
Paper Details
Formulation of Multi-Functional Nanoparticles for Magnetic Tumour Targeting and their Biomedical Applications
Abstract
Magnetic nano-particles have provided with great therapeutic and diagnostic approach to study cancer. These particles have been using to trace the tumor aided by improved drug delivery system. Super-paramagnetic iron oxide nanoparticles (SPIONs) are highly magnetized to the targeted location of action upon contact to external magnetic field and no magnetization is engaged once the magnetic field is detached evading the accumulation. Formulation as well as characterization of red emmition of polymeric nanocapsules (NCs) including superparamagnetic iron oxide nano-particles for magnetic tumour targeting and biomedical imaging not completely described. The aims of this study is to measure the formulation and use of iron oxide nano- particles for magnetic tumour targeting and biomedical imaging. The self- fluorescent oligomers measured be synthesized and chemically conjugated to PLGA which measured and completed by NMR, FT-IR spectroscopy and mass spectrometry. Hydrophobic SPIONs measured be synthesized over thermal decay and their magnetic and heating possessions measured be assessed by SQUID magnetometry and calorimetric measurements. Magnetic nano-capsules (m-NC) measured and organized by single emulsification and solvent vanishing method. This research measured be helpful for evaluation on ability of the developed m-NC for multi-model bioimaging, magnetic- targeted drug delivery and encapsulation of the chemotherapeutic drug measured be the next stage studies.
Al-Jamal T, Bai J, Wang W, Protti P. 2016. Magnetic drug targeting: preclinical in vivo studies, mathematical modeling, and extrapolation to humans. Nano letters 16(2), 5652-5660.
Bakhtiary AA. 2016. Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges. Nanomedicine: Nanotechnology, Biology and Medicine 12(33), 287-307.
Kallumadil M. 2009. Suitability of commercial colloids for magnetic hyperthermia. Journal of Magnetism and Magnetic Materials 321(56), 1509-1513.
Klippstein RT. 2015. Passively Targeted Curcumin‐Loaded PEGylated PLGA Nanocapsules for Colon Cancer Therapy In Vivo 11(78), 4704-4722.
Mei KC, Bai S. 2016. Investigating the effect of tumor vascularization on magnetic targeting in vivo using retrospective design of experiment Biomaterials. 106(34), 276-285.
Naeem M, Ashraf A, Hafiz Safdar MZ, Khan MQ, Rehman SU, Iqbal R, Raza M, Ali J, Ahmad G. 2020. Biochemical Changes in Patients with Chronic kidney Failure In Relation to Complete Blood Count and Anemia. International Journal of Biosciences 16(1), 267-271.
Pennakalathil J, Jahja E. 2014. Red emitting, cucurbituril-capped, pH-responsive conjugated oligomer-based nanoparticles for drug delivery and cellular imaging. Biomacromolecules.15(34), 3366-3374.
Sawaengsak C, Mori Y, Yamanishi K, Mitrevej A, Sinchaipanid N. 2014.Sinchaipanid ,Chitosan nanoparticle encapsulated hemagglutinin-split influenza virus mucosal vaccine. AAPS Pharmaceutical Scientific Technology 15(2), 317-325.
Schneider LP, Schoonderwoerd AJ, Moutaftsi M, Howard RF, Reed SG, Jong EC, Teunissen MB. 2012. Teunissen, Intradermally administered TLR4 agonist GLA-SE enhances the capacity of human skin DCs to activate T cells and promotes emigration of Langerhans cells. Vaccine 30(28), 4216-4224.
Shah MA, Ali Z, Ahmad R, Qadri I, Fatima K. 2015. DNA mediated vaccines delivery through nanoparticles. Nanoscale Research Letters 15(1), 41-53.
Silva AL, Rosalia R A, Sazak A, Carstens MG, Ossendorp F, Oostendorp J, Jiskoot JW. 2012. Optimization of encapsulation of a synthetic long peptide in PLGA nanoparticles: Low-burst release is crucial for efficient CD8+ T cell activation. European Journal of Biopharmcay 83(3), 338-345.
Treuel L, Jiang X, Nienhaus GU. 2012. New views on cellular uptake and trafficking of manufactured nanoparticles. Journal of Royal Society of Interfernce 10(82), 09-39.
Treanor JJ, Essink B, Hull S, Reed S, Izikson R, Patriarca P, Dunkle LM. 2013. M, Evaluation of safety and immunogenicity of recombinant influenza hemagglutinin formulated with and without a stable oil-in-water emulsion containing glucopyranosyl-lipid A (SE+ GLA) adjuvant. Vaccine 31(48), 5760-5765.
Wang T, Zou M, Jiang H, Ji Z, Gao P, Cheng G. 2011. Synthesis of a novel kind of carbon nanoparticle with large mesopores and macropores and its application as an oral vaccine adjuvant. Euro.J. PharmBiopharm 44(5), 653-659.
Wang Y. 2016. FDA’s regulatory science program for generic PLA/PLGA-based drug products. American pharmaceutical review 19, 5–9.
Wu M, Huang M. 2017. Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment. Molecular and clinical oncology 7, 738-746.
Yu J, Rong Y, Zhou F, Chiu DT. 2017. Recent advances in the development of highly luminescent semiconducting polymer dots and nanoparticles for biological imaging and medicine. Analytical chemistry 89, 42-56.
Zhang L. 2006. Oleic acid coating on the monodisperse magnetite nanoparticles. Applied Surface Science 253, 2611-2617.
Sabahat Irfan, Komal Shahzadi, Rubab Yousaf, Fazeela Zaka, Haiqa Masoud, Sania Riasat, Taiyyiabah Basharat, Saira Batool, 2020. Formulation of Multi-Functional Nanoparticles for Magnetic Tumour Targeting and their Biomedical Applications. Int. J. Biosci., 17(3), 74-81.
Copyright © 2020 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.