Hepatoprotective effects of arabica coffee beans in paracetamol induced hepatotoxic animal models
Paper Details
Hepatoprotective effects of arabica coffee beans in paracetamol induced hepatotoxic animal models
Abstract
Drug detoxification functioning of liver exposes it to a variety of toxic metabolites and the damage due to toxins can lead to liver diseases. However, treatment options for liver pathologies are very limited in conventional medicines, therefore, the focus has been shifted more towards alternatives routes to restore the functions of liver. Coffee is a widely consumed beverage that has exhibited improvement in liver physiology. This study was carried out to investigate the hepatoprotective effects of Arabica coffee beans by in New Zealand rabbits that exhibited drug toxicity following an overdose of paracetamol via oral ingestion. To evaluate whether coffee offers hepatoprotection at earliest hour of its consumption, a group of animals received co-treatment of Arabica coffee beans and paracetamol. Another group received paracetamol only. A control group of animals was also included for comparison. Liver function, lipid profile, renal efficiency and CYP2E1 gene expression of all the animals in each group were estimated. Arabica coffee beans showed a decrease in ALT and ALP levels and restoration of ferritin. Lipid profile tests displayed that coffee group showed a reduction in TL and TC level, TG were elevated and LDL were restored and no change was found for HDL levels. Coffee consumption was found to increase the urea and creatinine levels. Upregulated gene expression of CYP2E1 indicated liver injury in paracetamol group whereas coffee significantly downregulated it. Thus, coffee beans exhibited hepatoprotective actions along with the restoration of lipid profile in acute liver injury animal models of 4 hour.
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