home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

A comparative study for evaluation of uric acid among age-wise and gender-wise in district Toba Tek Singh

Paper Details

Research Paper 01/05/2021
Views (541) Download (33)
current_issue_feature_image
publication_file

A comparative study for evaluation of uric acid among age-wise and gender-wise in district Toba Tek Singh

Tanwir Ahmad Abbas Khichi, Tausif Ahmad, Muhammad Aun Naqvi, Sajjad Hussain, Syedah Andleeb, Zinnia Mansoor, Aasma Noureen, Tanveer Hussain, Haleema Sadia, Shahzad Aamir, Sohail
Int. J. Biosci.18( 5), 1-6, May 2021.
Certificate: IJB 2021 [Generate Certificate]
Key: Age groupsReference valueToba Tek SinghUric acid

Abstract

The present study conducted in Toba Tek Singh district to assess a prevalence for increased uric acid level. For this study, 300 samples were taken among healthy individuals. The samples examined in a laboratory to determine a serum uric acid concentrations in all the selected samples. All the 300 samples were subjected to determine a mean uric acid value. This data was compared within selected samples age-wise and gender-wise. The reference value in male and female was 3.5-7.0 mg/dL and 2.5-6.0 mg/dL respectively. The results determined that uric acid value was high in a group of 10-30 years of age. In this group, a mean uric acid value is 5.17±1.02mg/dL. In a group of 31-50 years of age, the average uric acid value found 5.14±0.91 mg/dL that is lower than a group of 10-30 years of age. The mean serum uric acid value of a group of 51-70 years of age is 5.4±1.34 mg/dL, while 5.47±1.27 mg/dL is a mean serum uric acid value of an age group of 71-90 years. All groups study showed that serum uric acid level is increased by increasing age of males while in the case of female it is increased after 50 years of age. It is due to the hormonal effect as the level of estrogen in the female is high. The increased level of Uric acid leads to gouty arthritis, cardiovascular disease in females, cancer mortality in male, kidney diseases and diabetes millets.

VIEWS 69
Cover PDF

Antón FM, Puig JG, Ramos T, González P, Ordas J. 1986. Sex differences in uric acid metabolism in adults: evidence for a lack of influence of estradiol-17β (E2) on the renal handling of urate. Metabolism 35(4), 343-348.

Chiou WK, Wang MH, Huang DH, Chiu HT, Lee YJ, Lin JD. 2010. The relationship between serum uric acid level and metabolic syndrome: differences by sex and age in Taiwanese. Journal of epidemiology p 1003170155-1003170155.

Church WH, Ward VL. 1994. Uric acid is reduced in the substantia nigra in Parkinson’s disease: effect on dopamine oxidation. Brain research bulletin 33(4), 419-425.

Das M, Borah NC, Ghose M, Choudhury N. 2014. Reference ranges for serum uric acid among healthy Assamese people. Biochemistry research international 2014.

Dodge HJ, Mikkelsen WM. 1970. Observations on the distribution of serum uric acid levels in participants of the Tecumseh, Michigan, Community Health Studies: A comparison of results of one method used at two different times and of two methods used simultaneously. Journal of chronic diseases 23(3), 161-172.

Kanbay M, Ozkara A, Selcoki Y, Isik B, Turgut F, Bavbek N, Uz E, Akcay A, Yigitoglu R, Covic A. 2007. Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions. International urology and nephrology 39(4), 1227-1233.

Mazzali M, Kanbay M, Segal MS, Shafiu M, Jalal D, Feig DI, Johnson RJ. 2010. Uric acid and hypertension: cause or effect?. Current rheumatology reports 12(2), p 108-117.

Nagahama K, Iseki K, Inoue T, Touma T, Ikemiya Y, Takishita S. 2004. Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan. Hypertension Research 27(4), 227-233.

Povoroznyuk VV, Dubetska GS. 2012. Hyperuricemia and age. Gerontologija 13(3), p 149-153.

Rehman A, Naqvi SA. 1980. Serum and urinary uric acid in relation to age and sex. J Pak Med Assoc 30(11), 242-4.

Sari I, Akar S, Pakoz B, Sisman AR, Gurler O, Birlik M, Onen F, Akkoc N. 2009. Hyperuricemia and its related factors in an urban population, Izmir, Turkey. Rheumatology international 29(8), p 869-874

Shima Y, Teruya K, Ohta H. 2006. Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese. Life sciences 79(23), 2234-2237.

So A, Thorens B. 2010. Uric acid transport and disease. The Journal of clinical investigation 120(6), 1791-1799.

Voruganti VS, Franceschini N, Haack K, Laston S, MacCluer JW, Umans JG, Comuzzie AG, North KE, Cole SA. 2014. Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. European Journal of Human Genetics 22(7), 938-943.

Wayner DD, Burton GW, Ingold KU, Barclay LR, Locke SJ. 1987. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochimica et Biophysica Acta (BBA)-General Subjects 924(3), p 408-419.

Submit Manuscript