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A composite review of Berberis in service of humanity-in-trouble: an ethnopharmacological and pharmacognosic perspective

Tika Khan, Imtiaz Ahmed Khan, Abdul Rehman

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J. Bio. Env. Sci.6(5), 21-33, May 2015

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Abstract

Berberis, being one of the oldest therapeutic sources has been frequently used in traditional and modern health care systems across the globe. It is included in pharmacopoeia of British, India, China and several other Homeopathic Materia Medica. Out of 29 (6-7%) Berberis species reported for their various ethnobotanical uses, seventeen (n=17, 3-4%) were found are used to treat almost hundred (n=100) human diseases ranging from skin irritation to diabetes, cardiac ailments and acquired immune deficiency syndrome (HIV/AIDS). Among these species, B. lyceum exhibited the widest utility scope with thirty seven (n=37) diseases followed by B. aristata/ chitria (n=32), B. pseudumbellata (n=18), B. holstii (n=18), B. vulgaris/kunawurensis (n=17), B. asiatica (n=16), B. jeshkeana (n=11), B. aquifolium (n=4), B. petiolaris (n=3), B. ulicina (n=3), B. tinctoria (n=2), B. haematocarpa (n=2), B. walichina (n=2), B. crataegina (2), B. pachyacantha (n=1) and B. coriacea (n=1). Different diseases showed differential number of Berberis species used for their treatment. Jaundice and hepatic disorders are treated with ten (n=10, 5.92%) different species. Eye (opthalemic), malaria and fever were treated using 8 (4.73%), 6 (3.55%) and 5 (2.96%) species respectively. Fifty seven percent (n=53, 57%) diseases are treated with different but single species. Review revealed that Berberis species a great potential source for alternative, safer, effective, less expensive use, instead of various in-effective, expensive and unsafe allopathic medication. Study was aimed at exploration of various Berberis species used for different human diseases along with their scale and scope.

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A composite review of Berberis in service of humanity-in-trouble: an ethnopharmacological and pharmacognosic perspective

Ahmad R, Srivastava SP, Maurya R, Rajendran SM, Arya KR, Srivastava AK. 2008. Mild antihyperglycaemic activity in Eclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula. Indian Journal of Science and Technology 1(5), 1-6.

Ahrendt LWA. 1961. Berberis and Mahonia: a taxonomic revision. Journal of Linnaean Society of London, Botany 57, 1–410.

Adhikari BS, Babu MM, Saklani PL, Rawat GS. 2007. Distribution, use pattern and prospects for conservation of medicinal shrubs in Uttaranchal State, India. Journal of Mountain Science 4(2), 155-180.

Afzal S, Afzal N, Awan MR, Khan TS, Gilani A, Khanum R, Tariq S. 2009. Ethno-botanical studies from northern Pakistan. J. Ayub. Med. Col. Abbott 21(1), 52-57.

Ahamad J, Mir SR, Naquvi KJ. 2012. Hypoglycemic activity of aqueous extract of Berberis aristata stems bark in STZ induced rats. Int J Pharm Pharm Sci 4(2), 473–474.

Ahmed E, Arshad M, Ahmad M, Saeed M, Ishaque M. 2004. Ethnopharmacological survey of some medicinally important plants of Galliyat areas of NWFP, Pakistan. Asian. J. Pl. Sci 3(4), 410-415.

Ahmed M, Alamgeer, Sharif T, Zabta CHM, Akbar A. 2009. Effect of Berberis lycium Royle on Lipid Profile in Alloxan Induced Diabetic Rabbits. Ethnobot. Leaflets 13, 702-708.

Ali M, Malik AR, Sharma KR. 2008. Vegetative propagation of Berberis aristata DC. An endangered Himalayan shrub. Journal of Medicinal Plants Research 2(12), 374-377.

Anonymous. 2014. Indian Science.org. retrieved from http://www.indianscience.org/essays/20-%20E– Himalayan%20Medicine%20System%20fine12.pdf on July 7, 2014.

Asif A, Kabub G, Mehmood S, Khunum R, Gulfraz M. 2007. Wound healing activity of root extract of Berberis Lyceum Royle in rats. Phytother. Research 21, 589-591.

Awan MR, Jamal Z, Khan A. 2013. Ethno-Botanical Studies Of Economically Important Plants From Mountainous Region Of Gilgit-Baltistan, Pakistan. Sci., Tech. and Dev 32 (4), 308-318.

Babber OP, Chhatwal VK, Ray IB, Mehra MK. 1982. Effects of berberine chloride eye drops on clinically positive trachoma patients Indian. J. Med. Res 76, 83-88.

Baquar SR. 1989. Medicinal and Poisonous plants of Pakistan, (Karachi, Pakistan: Printas) p.55.

Basak S, Sarma GC, Rangan L. 2010. Ethnomedical uses of Zingiberaceous plants of Northeast India. Journal of Ethnopharmacology 132(1), 286-296.

Bashir S, Gilani AH, Siddiqui AA, Pervez S, Khan SR, Sarfaraz NJ, Shah AJ. 2010. Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats. Phytotherapy Research 24(8), 1250-1255.

Bhupendra S, Adhikari et al. 2007. Distribution, Use Pattern and Prospects for Conservation of Medicinal Shrubs in Uttaranchal State, India. .Journal of Mountain Science 4(2), 155-180. DOI:10.1007/s11629-007-0155-8.

Bottini MCJ, De Bustos A, Sanso AM, Jouve N, Poggio L. 2007. Relationships in Patagonian species of Berberis (Berberidaceae) based on the characterization of rDNA internal transcribed spacer sequences. Botanical Journal of the Linnean Society 153(3), 321-328. DOI: 10.1111/j.1095-8339.2007.00586.x.

Caraballo A, Caraballo B, Rodríguez-Acosta A. 2004. Preliminary assessment of medicinal plants used as antimalarials in the southeastern Venezuelan Amazon. Revista da SociedadeBrasileira de Medicina Tropical 37(2), 186–188.

Chamberlain DF, Hu CM. 1975. A synopsis of Berberis section Wallichianae. Notes from the Royal Botanic Garden Edinburgh 42(3), 529-557.

Chandra P, Purohit AN. 1980. Berberine contents and alkaloid profile of Berberis species from different altitudes. Biochemical Systematics and Ecology 8(4), 379–380.

Chopra M, Chatterji A, Pakrashi SC. 1981. The treatise on Indian medicinal plants CSIR, New Delhi pp. 33-35.

Chopra RN, Chopra IC. 1933. Indigenous drugs of India. Academic publishers.

Das S, Das MK, Mazumder PM, Das S, Basu SP. 2009. Cytotoxic activity of methanolic extract of Berberis aristata DC on colon cancer. Global Journal of Pharmacology 3(3), 137-140.

Das I, Singh Y, Ansari SA, Agrawal NR. 2005. In vitro dissolution of gallbladder stone by edible leaves, fruits and homoeopathic medicines. Journal of crystal growth 283(3), 508-513.

Deepak P, Gopal GV. 2014. Ethnomedicinal Practices of Kurumba Tribes, Niligiri District, Tamil Nadu, India, In Treating Skin Diseases. Global J Res. Med. Plants & Indigen. Med.| Volume 3(1), 8-16.

Dev S. 2006. A selection of prime ayurvedic plants drugs ancient- modern concordance. Anamaya Publishers, New Delhi.

Djeridane A, Yousfi M, Nadjemi B, Boutassouna D, Stocker P, Vidal N. 2006. Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chemistry 97(4), 654-660.

Duke JA, Godwin MB, Decellier J, Duke PA. 2002. CRC- Hand Book on Medicinal Plants. Taylor and Francis. Inc pub.SBN-13, Edition 2, pp 821.

Fata A, Rakhshandeh H, Berenji F, Jalalifard A. 2006. Treatment of cutaneous leishmaniasis in murine model by alcoholic extract of Berberis vulgaris. Iranian J Parasitol 1(1), 39-42.

Fatehi M, Saleh TM, Fatehi-Hassanabad Z, Farrokhfal K, Jafarzadeh M, Davodi S. 2005. A pharmacological study on Berberis vulgaris fruit extract. Journal of Ethnopharmacology 102(1), 46–52.

Gilani AH, Janbaz KH, Aziz N, Herzig MJU, Kazmi MM, Choudhary MI, Herzig JW. 1999. Possible mechanism of selective inotropic activity of the n-butanolic fraction from Berberis aristata fruit. Gen Pharmacol 33(5), 407–414.

Gosh AK, Bhattacharyya FK, Ghosh DK. 1990. Leishmania donovani: A mastigote Inhibition and mode of action of berberine. Exp. Para 60(3). 404-413.

Gulfraz M, Mehmood S, Ahmad A, Fatima N, Praveen Z, Williamson EM. 2008. Comparison of the antidiabetic activity of Berberis lyceum root extract and berberine in alloxan‐induced diabetic rats. Phytotherapy Research 22(9), 1208-1212.

Gupte S. 1975. Use of berberine in treatment of giardiasis. American Journal of Diseases of Children 129(7), 866-866.

Hamayun M, Khan A, Khan MA 2005. Common Medicinal Folk Recipes of District Buner, NWFP, Pakistan. Ethnobot. Leaflets 1, 45.

Hamayun M, Khan SA, Sohn EY, In-jung L. 2006. Folk medicinal knowledge and conservation status of some economically valued medicinal plants of District Swat Pakistan. Lyonia 11(2), 101-113.

Hedberg I, Hedberg O, Madati PJ, Mshigeni KE, Mshiu EN, Samuelsson G. 1982. Inventory of plants used in traditional medicine in Tanzania I. Plants of the families Acanthaceae – Cucurbitaceae. J. Ethnopharmacol 6, 29-60.

Himalaya. 2014. Indian Berberry, Tree Turmeric (Berberis aristata DC.). Retrieved from http://www. himalayawellness.com/herbfinder/berberis-aristata.htm on June 28, 2014.

Hussain I, Bano A, Ullah F. 2011. Traditional drug therapies from various medicinal plants of central Karakoram National Park, Gilgit-Baltistan, Pakistan. Pak J Bot 10, 79-84.

Hussain I, Bano A, Ullah F. 2011. Traditional Drug Therapies From Various Medicinal Plants Of Central Karakoram National Park, Gilgit-Baltistan, Pakistan. Pak. J. Bot., 43, 79-84, Special Issue, December, (Medicinal Plants: Conservation & Sustainable use).

Hussain MA, Khan MQ, Habib T, Hussain N. 2011. Antimicronbial activity of the crude root extract of Berberis lycium Royle. Adv Environ Biol 5(4), 585–588.

Hwang Jin-Ming, Wang Chau-Jong, Chou Feu-Pi, Tseng Tsui-Hwa, Hsieh Yih-Shou, Lin Wea-Lung, Chu Chia-Yih. 2002. Inhibitory effect of Berberine on tert-butyl hydroperoxide induced oxidative damage in rat liver. Archives of Toxicology 76(11), 664-670.

Ivanoska N, Philipov S. 1997. Study on the anti-inflammatory action of Berberis vulgaris root extracts, alkaloid fractions and pure alkaloid. International Journal of Immunopharmacology 18(10), 553–561.

Jain SK. 1994. Ethnobotany and research in medicinal plants in India. Ethnobot. Search New Drugs 185, 153-168.

Janbaza KH, Gilanib AH. 2000. Studies on preventive and curative effects of Berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 71(1), 25–33.

Joshi PV, Shirkhedkar AA, Prakash K, Maheshwari VL. 2011. Antidiarrheal activity, chemical  and  toxicity  profile  of  Berberis  aristata. Pharm Biol 49(1), 94–100.

Kala CP. 2000. Status and conservation of rare and endangered medicinal plants in the Indian trans-Himalaya. Biological Conservation 93(3), 371-379.

Kala CP. 2006. Medicinal plants of the high altitude cold desert in India: diversity, distribution and traditional uses. The International Journal of Biodiversity Science and Management 2(1), 43-56.

Karimov A. 1993. Berberis alkaloids. Chem Nat Compd 29(4), 415–438.

Kaur C, Miani SB. 2001. Fruits and vegetables health foods for new millennium. Indian Hort 45(4), 29-32.

Khan AA, Ashfaq A, Ali MN. 1979. Pharmacognostic Studies of Selected Indigenous Plants of Pakistan. (Peshawar: Spinezer Printers, Pakistan Forest Institute).

Khan M, Giessrgl B, Vonach C, Madlener S, Prinz S, Herbaceck I, Hölzl C, Bauer S, Viola K, Mikulits W, Quereshi RA, Knasmüller S, Grusch M, Kopp B, Krupitza G. 2010. Berberine and a Berberis lycium extract inactivate Cdc25A and induce α tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mut. Res 683, 123-130.

Khan MA, Kkan MA, Hussain M. 2012. Medicinal plants used in folk recipes by the inhabitants of Himalayan Region Poonch valley Azad Kashmir (Pakistan). J. Basic. Appl. Sci 8, 35-45.

Khan SM, Page S, Ahmad H, Harper D. 2012. Anthropogenic influences on the natural ecosystem of the Narran valley in the western Himalayas. Pak. J. Bot 44, 231-238, Special Issue May 2012.

Khan T, Khan IA, Ahmed K, Rehman A. 2014. Differential levels of susceptibility of Berberis species to insect attack at various altitudes in Karakoram Ranges. International Journal of Biosciences 4(5), 92-101. DOI: http://dx.doi.org/10.12692/ijb/4.5.92-101.

Khan T, Khan IA, Rehman A, Alam J, Ali S. 2013. Exploration of near-extinct folk wisdom on medicinally important plants from Shinaki Valley Hunza, Pakistan. International Journal of Biosciences 3(10), 180-186.

Khan SM, Ahmad H, Page S, Harper DM. 2012. Anthropogenic influences on the natural ecosystem of the Naran Valley in the western Himalayas. Pakistan Journal of Botany 44, 231-238.

Kiasalari Z, Khalili M, Ahmadi P. 2011. Effect of alcoholic extract of Berberis vulgaris fruit on acute and chronic inflammation in male rats. J Babol Univ Med Sci 13(1), 28–35.

Kirtikar KR, Basu BD. 1998. Indian medicinal plants, vol 1 CSIR publication, India.

Kokwaro JO. 1993. Medicinal plants of East Africa. Kenya Literature Bureau, Nairobi.

Koo L, Seang K. 1996. Inhibitory effect of protoberberine alkaloids from the roots of Coptis japonica on chatecolamine biosynthesis in PC12 cells. PlantaMedica 62(1), 31-34.

Kuo CL, Chi CW, Liu TY. 2004. The anti-inflammatory potential of Berberine in vitro and in vivo. Cancer Letters 203(2), 127–137.

Landrum LR. 1999. Revision of Berberis (Berberidaceae) in Chile and adjacent southern Argentina. Annals of the Missouri Botanical Garden 793-834.

Loconte H. 1993. Berberidaceae. The Families and Genera of Vascular Plants. II. Flowering Plants-Dicotyledons.(Eds.): K. Kubitzki, J.G. Rohwer & V. Bittrich. Springer-Verlag: Berlín.

Mahmood A, Ahmad M, Jabeen A, Zafar M, Nadeem S. 2005. Pharmacognostic Studies of Some Indigenous Medicinal Plants of Pakistan. Ethnobot. Leaflets 9, 20.

Mahmood A, Mahmood A, Malik RN. 2012. Indigenous knowledge of medicinal plants from Leepa valley, Azad Jammu and Kashmir, Pakistan. Journal of ethnopharmacology 143(1), 338-346.

Makkar HPS, Francis G, Becker K. 2007. Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems.

Meliani N, Dib MEA, Allali H, Tabti B. 2011. Hypoglycaemic effect of Berberis vulgaris L in normal and streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 1(6), 468–471.

Minaiyan M, Ghannadi A, Mahzouni P, Jaffari -Shirazi E. 2011. Comparative study of Berberis vulgaris fruit extract and berberine chloride effects on acetic acid-induced colitis in rats. Iranian journal of pharmaceutical research: IJPR 10(1), 97.

Mohan M, Pant MCR, Angea SK, Mahajan VM. 1982. Berberine in trachoma. Indian J. Ophthalmol 30, 69-75.

Mollik et al. 2010. A survey of medicinal plant usage by folk medicinal practitioners in two villages by the Rupsha River in Bagerhat district, Bangladesh. American-Eurasian Journal of Sustainable Agriculture 4(3), 349-356.

Muthu C, Ayyanar M, Raja N, Ignacimuthu S. 2006. Journal of Ethnobiology and Ethnomedicine. Journal of Ethnobiology and Ethnomedicine 2, 43.

Negi CS, Nautiyal S, Dasila L, Rao KS, Maihkuri RK. 2002. Ethnomedicinal Plant Uses in a Small Tribal Community in a Part of Central Himalaya, India. J. Hum. Ecol 14(1), 23–31.

Nyirenda CP. 2008. The conservation biology of Berberis holstii Engl. in Nyika National Park, Malawi.

Pandak JRWM, Zhou H. 2010. Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages. PLoS One 5(2), e9069.

Perveen A, Qaiser M. 2010. Pollen flora of Pakistan–LXV. berberidaceae. Pakistan Journal of Botany 42(1), 1-6.

Peychev L. 2005. Pharmacological investigation on the cardiovascular effects of Berberis vulgaris on tested animals. Pharmacia 52, 118-121.

Prihoda ND, Arjanova OV, Yurchenko LV, Sokolenko NI, Vihrova LA, Pylypchuk VS, Kutsyna GA. 2007. Open label trial of adjuvant immunotherapy with Dzherelo, Svitanok, and Lizorm, in MDR-TB, XDR-TB and TB/HIV co-infected patients receiving anti-tuberculosis therapy under DOT. Journal of Medicinal Plants Research 1(5), 117-122.

Qureshi et al. 2009. Indigenous Medicinal Plants Used By Local Women In Southern Himalayan Regions Of Pakistan. Pak. J. Bot 41(1), 19-25.

Rajasekaran A, Kumar N. 2009. Rasont-A traditional crude drug prepared from Berberis spp and its uses. Indian journal of traditional knowledge 8(4), 562-563.

Roy A, Sahu RK, Gupta R, Pandey P. 2011. Hepatoprotective activity of Berberis coriaceae on liver damage induced by CCL4 in rats. Pharmaco-logyonline 3, 838–842.

Sack RB, Froelich JL. 1982. Berberine inhibits intestinal secretor response of vibro choleare and Escherichia coli enteroxian. Infected Immunology 35, 471- 475.

Schaffer SaHM. 2005. Understanding local Mediterranean diets: A multidisciplinary pharmacological and ethnobotanical approach. Pharmacological Research, 52, 353 – 366.

Shamsa  F,  Ahmadiani  A,  Khosrokhavar  R. 1999. Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum. J Ethanopharmacol 64(2), 161–166.

Sharma C, Aneja KR, Kasera R. 2011. Screening of Berberis aristata DC for antimicrobial potential against the pathogens causing ear infection. Int J Pharmacol 7(4), 536–541; 56.

Sharma LN, Vetaas OR, Chaudhary RP, Måren IE. 2014. Ecological consequences of land use change: Forest structure and regeneration across the forest-grassland ecotone in mountain pastures in Nepal. Journal of Mountain Science 11(4), 838-849. DOI: 10.1007/s11629-013-2849-4.

Sheng-Ji P. 2001. Ethnobotanical approaches of traditional medicine studies: some experiences from Asia. Pharmaceutical biology 39(s1), 74-79.

Shinwari ZK. 2010. Medicinal plants research in Pakistan. J Med Plants Res 4(3), 161-176.

Sing R, Tiwari SS, Srivastava S, Ravat AK. 2012. Botanical and phytochemical studies on roots of Berberis umbellate Wall. ex G Don. Indian J Nat Prod Resour 3(1), 55-60.

Sood P, Modgil R, Sood M. 2012. Berberis lycium, a medicinal plant with immense value. Ind J Pharmaceut Biol Res 1(1), 1-8.

Tait Y, Harper J. 1999. Haemochromatosis. Australian Journal of Medical Herbalism 11(1), 41.

Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y. 2009. Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. Journal of ethnopharmacology 126(1), 5-17.

Tewary DK, Bhardwaj A, Shanker A. 2005. Pesticidal activities in five medicinal plants collected from mid hills of western Himalayas. Indus. Crop. Prod 22, 241-247.

Tiwari JK, Dangwal LR, Rana CS, Tiwari P, Ballabha R. 2010. Indigenous uses of plant species in Nanda Devi Biosphere Reserve, Uttarakhand, India. Repo. Opin 2(2), 58-61.

Tripathi YB, Shukla SD. 1996. Berberis aristata inhibits PAF induced aggregation of rabbit platelets. Phytother Res 10(7), 628–630.

Tuzlacı E, Erol MK. 1999. Turkish folk medicinal plants. Part II: Eğirdir (Isparta). Fitoterapia 70(6), 593-610.

Uniyal SK, Singh KN, Jamwal P, Lal B. 2006. Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalaya. Journal of Ethnobiology and Ethnomedicine 2(1), 14.

Upwar N, Patel R, Waseem N, Mahobia NK. 2011. Hypoglycemic effect of methanolic extract of Berberis aristata DC stem on normal and streptozotocin induced diabetic rats. Int J Pharm Pharm Sci 3(1), 222–224.

Usmanghani K, Saeed A, Alam MT. 1997. Indusyunic medicine, (Karachi, Pakistan: University of Karachi press) p.120.

Vermani K, Garg S. 2002. Herbal medicines for sexually transmitted diseases and AIDS. Journal of Ethnopharmacology 80(1), 49-66.

Villinski RJ, Dumas ER, Chai HB, Pezzuto JM, Angerhofer CK, Gafner S. 2003. Antibacterial activity and alkaloid content of Berberis thunbergii, Berberis vulgaris and Hydrastiscanadensis. Pharma-ceutical Biology 41(8), 551-557.

Waseem M, Shah MA, Qureshi RA, Iqbal M, Afza R, Yousaf S. 2006. Ethnopharmacological Survey of Plants Used for the Treatment of Stomach, Diabetes, and Ophthalmic Diseases in Sudhan Gali, Kashmir, Pakistan. Acta. Bot. Yunn 28(5), 535.

Xaio P. 1983. Recent developments on medicinal plants in China. Journal of ethnopharmacology 7(1), 95-109.

Yarnell E, Abascal K. 2005. Natural Approaches to Treating Chronic Prostatitis and Chronic Pelvic Pain Syndromes. Alternative & Complementary Therapies 11, 246 – 251.

Yeşilada E, Küpeli E. 2002. Berberis crataegina DC root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats. J Ethnopharmacol 79(2), 237–248.

Yogesh HS, Chandrashekhar VM, Katti HR, Ganapaty S, Raghavendra HL, Gowda GK, Goplakhrishna B. 2011. Anti-osteoporotic activity of aqueous-methanol extract of Berberis aristata in ovariectomized rats. Journal of ethnopharmacology 134(2), 334-338.

Zabihullah Q, Rashid A, Akhtar N. 2006. Ethnobotanical survey in kot Manzaray Baba valley Malakand agency, Pakistan. Pak. J. Plant Sci 12(2), 115-121.

Zaman MB, Khan S. 1970. Hundred Drug Plants of West Pakistan. (Peshawar, NWFP, Pakistan: Pakistan Forest Institute).

Zha W, Liang G, Xiao J, Studer EJ, Hylemon PB, Pandak JrWM, Zhou H. 2010. Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages. PLoS One 5(2), e9069.

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