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A review on different diseases due to human gut microbiota dysbiosis

Review Paper | July 1, 2021

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Afsheen Rafiq, Tazeem Zahra, Sajid Ali, Adnan Shahid, Muhammad Iqbal, Aurangzaib Ijaz, Muhammad Ahmed Mushtaq

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J. Bio. Env. Sci.19( 1), 1-10, July 2021


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Microbes are present everywhere on earth. These are present either inside or outside the body. Microorganisms are found in urinary tract, vagina, gut, nasal cavity, oral cavity and many other parts of body as well. These microbes are beneficial as well as harmful for us. Beneficial microbes can regulate different body mechanisms and sometimes they can convert into pathogenic microbes. Human gut microbiota is necessary in keeping the brain healthy as well as it also maintains the physical health of humans. Microbiota of human gut is made up of complex community of microorganisms that respond in healthy metabolic processes and develop immune responses, but sometimes gut microbiota can be disturbed by different external and internal factors for example antibiotics, more lipid diet, and stress that can cause alteration in gut microbiota. So pathogenic microbes accumulate and release different toxins that cause various diseases such as Alzheimer’s Disease, colorectal cancer, cardiovascular diseases, obesity, Clostridium difficile infection, Inflammatory bowel disease, etc. The dysbiosis in human gut microbes is due to release of different toxins from pathogenic bacteria which are converted from beneficial bacteria by internal and external factors. If we will not control these factors it can also change the gene expression and will infect the next generations too. We can prevent these diseases by less use of antibiotics and by taking proper healthier diet it will help in maintenance of normal flora of body.


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A review on different diseases due to human gut microbiota dysbiosis

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