A review on paratuberculosis (Mycobacterium avium subspecies paratuberculosis) in domestic animals

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Review Paper 01/12/2019
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A review on paratuberculosis (Mycobacterium avium subspecies paratuberculosis) in domestic animals

S.S.H. Bukhari, A.M.Gill, E. Mahboob, M. Moazam, S. Ali5, M.U. Farooq
Int. J. Biosci.15( 6), 186-193, December 2019.
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Paratuberculosis is a production limiting disease of ruminants, also causes infection in non-ruminants and birds; caused by Mycobacterium avium subspecies paratuberculosis (MAP), characterized by chronic intestinal inflammation, intermittent diarrhea, progressive weight loss and ultimately death of animal. In a herd; vertical as well as horizontal transmission occurs as a result of fecal contamination, through colostrum or common feeding and watering.  It is diagnosed by clinical examination and through certain biochemical and serological tests such as Polymerase chain reaction, Enzyme linked immunosorbent assay and Ager gel immunodiffusion test. It is considered as non-curable disease and can be controlled by vaccine, proper management and culling of infected animals.


Ahmed I. 2010. Serodiagnosis of Johne’s disease by indirect ELISA in ovine. Iraqi Journal of Veterinary Sciences 24(1), 41 (En)-43 (En). (ISSN: 16073894).

Al-Ghamdi G. 2013. Mycobacterium avium subspecies paratuberculosis in camels; Clinical aspects and control suggestions. Egyptian Academic Journal of Biological Sciences 5, 11-15. http://dx.doi.org/10.21608/EAJBSG.2013.16640

Arrazuríaa R, Arnaiz I, Fouz R, Calvo C, Eires C, Dieguez FJ. 2014. Association between Mycobacterium avium subsp. paratuberculosis infection and culling in dairy cattle herds. Archivos de Medicina Veterinaria 46, 39-44.

Ayele WY, Machackova M, Pavlik I. 2001. The transmission and impact of paratuberculosis infection in domestic and wild ruminants. Veterinarni Medicina 46(7-8), 205-224. (Google Scholar indexed, http://citeseerx.ist.psu.edu/viewdoc/download?doi=

Bhattarai B, Fosgate GT, Osterstock JB, Park SC, Roussel AJ. 2014. Perceptions of veterinarians and producers concerning Johne’s disease prevalence and control in US beef cow-calf operations. BMC veterinary research 10(1), 1. https://doi.org/10.1186/1746-6148-10.27

Bonhotal J, Schwarz M, Stehman SM. 2011. How Mycobacterium avium paratuberculosis is affected by the composting process. Trends in Animal and Veterinary Sciences 2(1), 5-10. http://dx.doi.org/hdl.handle.net/1813/24404

Cousins D, Condron RJ, Eamens GJ, Whittington RJ, De Lisle GW. 2002. Paratuberculosis (Johne’s disease). Australia and New Zealand Standard Diagnostic Procedures 1, 1-21. https://www.researchgate.net/profile/Richard_Whittington3/publication/228937426_Paratuberculosis_Johnes_Disease/links/548566ad0cf283750c3714afpdf

Dow CT. 2012. M. paratuberculosis heat shock protein 65 and human diseases: bridging infection and autoimmunity. Autoimmune diseases 2012. http://dx.doi.org/10.1155/2012/15082.4

Eltholth M, Marsh VR, Winden SV, Guitian FJ. 2009. Contamination of food products with Mycobacterium avium paratuberculosis: a systematic review. Journal of Applied Microbiology 107(4), 1061-1071. https://doi.org/10.1111/j.1365-2672.2009.042.86.x

Forde T, Orsel K, Buck JD, Buck SD, Cote SD, Cuyler C, Davison T, Elkin B, Kelly A,  Kienzler M, Popko R, Tailon J, Veitch A, Kutz S. 2012. Detection of Mycobacterium avium subspecies paratuberculosis in several herds of Arctic Caribou (Rangifer tarandus ssp.). Journal of wildlife diseases 48(4), 918-924. https://doi.org/10.7589/2011-09-2.61

Geraghty T, Graham DA, Mullowney P, More SJ. 2014. A review of bovine Johne’s disease control activities in 6 endemically infected countries. Preventive veterinary medicine 116(1), 1-11. https://doi.org/10.1016/j.prevetmed.201406.003

Goswami TK, Joardar SN, Ram GC, Banerjee R, Singh DK. 2000. Association of Mycobacterium paratuberculosis in Crohn’s disease and Johne’s disease: A possible zoonotic threat. CURRENT SCIENCE-BANGALORE- 79(8), 1076-1080. https://www.jstor.org/stable/24.104361?seq=1

Greenstein RJ. 2003. Is Crohn’s disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne’s disease. The Lancet infectious diseases 3(8), 507-514. https://doi.org/10.1016/S1473-3099(03)007.24-2

Hermon TJ. 2002. Treatment with drugs active against Mycobacterium avium subspecies paratuberculosis can heal Crohn’s disease: more evidence for a neglected public health tragedy. Digestive and Liver Disease 34(1), 9-12. https://doi.org/10.1016/S1590-8658(02)80052-4

Heuer C, Wilson P. Larking K. 2011. Johne’s disease in New Zealand livestock. Vetscript 24(2), 39-41. (Google Scholar indexed, https://www.jdrc.co.nz/s/report-5a1Heuervetscript_Mar11_4-1-2.pdf

Kopecna M, Parmova I, Bartosova LD, Moravkova M, Babak V, Pavlik I. 2008. Distribution and transmission of Mycobacterium avium subspecies paratuberculosis in farmed red deer (Cervus elaphus) studied by faecal culture, serology and IS900 RFLP examinations. Veterinarni Medicina 53(9), 510-523. (Google Scholar indexed, http://citeseerx.ist.psu.edu/viewdoc/download?doi=

Laszczych AW, Szteyn J, Ruszczynska A. 2010. A case study of the clinical form of Johne’s disease in a heifer. Turkish Journal of Veterinary and Animal Sciences 34(1), 95-99. https://doi.org/10.3906/vet-0804-8

Manning E. Collins M. 2001. Mycobacterium avium subsp. paratuberculosis: pathogen, pathogenesis and diagnosis. Revue scientifique et technique (International Office of Epizootics) 20(1), 133-150. Google Scholar indexed. https://pdfs.semanticscholar.org/922d/b3c510803170c4c644d17f9e63ffe09c2574.pdf

Marcé C, Ezanno P, Seegers H, Pfeiffer DU, Fourichon C. 2011. Predicting fadeout versus persistence of paratuberculosis in a dairy cattle herd for management and control purposes: a modelling study. Veterinary Research 42(1), 36. https://doi.org/10.1186/1297-9716-42-3.6

Masala S, Cossu D, Pacifico A, Molicotti P, Sechi LA. 2012. Sardinian Type 1 diabetes patients, Transthyretin and Mycobacterium avium subspecies paratuberculosis infection. Gut Pathogens 4(1), https://doi.org/10.1186/1757-4749-4-2.4

Mihajlovic B, Klassen M, Spiringthorpe S, Couture H, Farber J. 2011. Assessment of Sources of Exposure for Mycobacterium avium subsp. paratuberculosis in Food and Wate. International Food Risk Analysis Journal 1(2), 1-22. (Google Scholar Indexed https://hrcak.srce.hr/file/114175

Moser CL. 1982. Johne’s disease (paratuberculosis) in a goat. The Canadian Veterinary Journal 23(2), 63. (Google Scholar indexed, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790087/pdf/canvetj00279-0043.pdf

Nacy C, Buckley M. 2008. Mycobacterium avium paratuberculosis: infrequent human pathogen or public health threat. Mycobacterium Avium Paratuberculosis: Infrequent Human Pathogen or Public Health Threat?: 2008; Salem Massachusetts USA: 1-37. Google Scholar indexed, https://www.asmscience.org/content/report/colloquia.colloquia.33?crawler=redirect

Naser SA, Naser NA, Scheld WM, Hooper DV, Hughes JM. 2007. Mycobacterium avium subsp. paratuberculosis and Crohn’s disease. Emerging infections 7, 225-245. (Google Scholar indexed, https://oaktrust.library.tamu.edu/bitstream/handle/1969.1/ETD-TAMU-2510/PEARCE-THESIS.pdf?sequence=1

Naser SA, Sagramsingh SR, Naser AS, Thanigachalam S. 2014. Mycobacterium avium subspecies paratuberculosis causes Crohn’s disease in some inflammatory bowel disease patients. World J Gastroenterol 20(23), 7403-7415. https://doi.org/10.3748/wjg.v20.i23.7403

O’Brien R, Hughes A, Liggett S, Griffin F. 2013. Composite testing for ante-mortem diagnosis of Johne’s disease in farmed New Zealand deer: correlations between bacteriological culture, histopathology, serological reactivity and faecal shedding as determined by quantitative PCR. BMC veterinary research 9(1), 1. https://doi.org/10.1186/1746-6148-9.72

Okuni JB. 2013. Occurrence of Paratuberculosis in African Countries: a Review. Journal of Veterinary Advances 3(1): 1-8.   https://scholar.google.com.pk/scholar?hl=en&as_sdt=0%2C5&q=Okuni+JB.+2013.+Occurrence+of+Paratuberculosis+in+African+Countries%3A+a+Review.+Journal+of+Veterinary+Advances+3%281%29%3A+1-8.&btnG.=

Pieper L, Sorge U, Goskin A, DeVries T, Lissemore K, Kelton D. 2014. Management Practices and Their Potential Influence on Johne’s disease Transmission on Canadian Organic Dairy Farms—A Conceptual Analysis. Sustainability 6(11), 8237-8261. https://doi.org/10.3390/su611823.7

Rastogi N, Legrand E, Sola C. 2001. The mycobacteria: an introduction to nomenclature and pathogenesis. Revue Scientifique Et Technique-Office International Des Epizooties 20(1), 21-54. (Google Scholar Indexed https://www.researchgate.net/profile/Nalin_Rastogi/publication/12044467_The_mycobacteria_an_introduction_to_nomenclature_and_pathogenesis/links/00b7d51c7b997435a9000000.pdf

Rhodes G, Richardson H, Taylor JH, Weightman A, Higham A, Pickup R. 2014. Mycobacterium avium subspecies paratuberculosis: human exposure through environmental and domestic aerosols. Pathogens 3(3), 577-595. https://doi.org/10.3390/pathogens303057.7

Rodrick J, Herbert J, Richard S. 1984. Ruminant paratuberculosis (Johne’s disease): the current status and future prospects. The Cornell Veterinarian 74: 218-262. (Google Scholar indexed, https://www.researchgate.net/profile/Rodrick_Chiodini/publication/16820257_Ruminant_paratuberculosis_Johne’s_disease_The_current_status_and_future_prospects/links/566efcea08ae52dd6c12a5e9/Ruminant-paratuberculosis-Johnes-disease-The-current-status-and-future-prospects.pdf

Ryan T, Campbell D. 2006. Mycobacterium paratuberculosis-a public health issue. New Zealand Food Safety Authority. (Google Scholar Indexed, https://www.researchgate.net/profile/Donald_Campbell7/publication/237324187_Mycobacterium_paratuberculosis_-_A_Public_Health_Issue/links/54f8b15c0cf210398e96c835.pdf

Singh A, Singh SV, Sohal JS. 2010. Is Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in animals, a good candidate for Crohn’s disease in man? Indian Journal of Gastroenterology 29(2), 53-58. (Google Scholar indexed, https://www.researchgate.net/profile/Ajay_Vir_Singh/publication/44573758_Is_Mycobacterium_avium_subsp_paratuberculosis_the_cause_of_Johne’s_disease_in_animals_a_good_candidate_for_Crohn’s_disease_in_man/links/02bfe51396db704bf2000000/Is-Mycobacterium-avium-subsp-paratuberculosis-the-cause-of-Johnes-disease-in-animals-a-good-candidate-for-Crohns-disease-in-man.pdf

Singh S, Gopinath K. 2011. Mycobacterium avium subspecies Paratuberculosis and crohn’s regional ileitis: How strong is association? Journal of laboratory physicians 3(2), 69. https://doi.org/10.4103/0974-272786836

Singh SV, Gupta S, Chaubey KK, Kumar K, Rawat KD, Tiwari R, Dhama K. 2014. Dose standardization studies of Indigenous Vaccine for the control of Mycobacterium avium subspecies Paratuberculosis in naturally infected goats. Advances in Animal and Veterinary Sciences 2, 17-22. http://dx.doi.org/10.14737/journal.aavs/2014/2.1s.1722

Slana I, Paolicchi F, Janstova B, Navratilova P, Pavlik I. 2008. Detection methods for Mycobacterium avium subsp paratuberculosis in milk and milk products: a review. Veterinarni Medicina-Praha- 53(6), 283.

Sohal J, Singh SV, Singh B, Thakur S, Aseri GK, Jain N, Jayaraman S, Yadav P, Khare N, Gupta S, Chaubey KK, Dhama K. 2015. Control of paratuberculosis: Opinions and practices. Advances in Animal and Veterinary Sciences 3(3), 156-163. http://dx.doi.org/10.14737/journal.aavs/2015/

Sorge U, Kelton D, Lissemore K, Godkin A, Hendrick S, Wells’ S. 2010. Attitudes of Canadian dairy farmers toward a voluntary Johne’s disease control program. Journal of dairy science 93(4), 1491-1499. https://doi.org/10.3168/jds.2009-24.47

Stamp J, Watt J. 1954. Johne’s disease in sheep. Journal of Comparative Pathology and Therapeutics 64, 26-IN26. https://doi.org/10.1016/S0368-1742(54)800051

Sweeney R, Collins MT, Koets AP, McGuirk SM, Roussel AJ. 2012. Paratuberculosis (Johne’s disease) in cattle and other susceptible species. Journal of Veterinary Internal Medicine 26(6), 1239-1250. https://doi.org/10.1111/j.1939-1676.2012.01019x

Syed SHB, Muhammad AR, Usman G. 2019. Prevalence of Trypanosoma evansi (Surra) infection in Horses and Donkeys in Attock Region of Punjab, Pakistan. Saudi Journal of Biomedical Research 4(11), 402-404. http://dx.doi.org/10.36348/SJBR.2019.v04i11.006

Van Kooten H, Mackintosh CG, Koets AP. 2006. Intra-uterine transmission of paratuberculosis (Johne’s disease) in farmed red deer. New Zealand Veterinary Journal 54(1), 16-20. https://doi.org/10.1080/00480169.2006.365.98

Verma DK. 2013. Mycobacterium avium subspecies paratuberculosis: an Emerging Animal Pathogen of Global Concern. Advances in Bioresearch 4(4), 01-08. (Google Scholar Indexed, http://www.academia.edu/download/41177378/Reviwew_Article_ABR.pdf

Waddell LA, Rajic A, Sargeant J, Harris J, Amezcua R, Downey L, Read S, McEwen SA. 2008. The zoonotic potential of Mycobacterium avium spp. paratuberculosis: a systematic review. Canadian Journal of Public Health/Revue Canadienne de Sante’e Publique: 145-155. https://doi.org/10.1007/BF03405464

Wadhwa A, Kumar N, Velasco-Villa A, Eda S. 2013. Overview of Johne’s disease immunology. Veterinary World 6(11), 901-904. http://dx.doi.org/10.14202/vetworld.2013.901-904

Wayne LG. (1974). The Genus Mycobacterium. International Journal of Systematic and Evolutionary Microbiology 24(2), 308-308. https://doi.org/10.1099/00207713-24-2-308

Whittington RJ, Windsor PA. 2009. In utero infection of cattle with Mycobacterium avium subsp. paratuberculosis: a critical review and meta-analysis. The Veterinary Journal 179(1), 60-69. https://doi.org/10.1016/j.tvjl.2007.08.0.23

Zanella R, Settles ML, McKay SD, Schnabel R, Taylor J, Whitlock RH, Schukken Y, Van Kessel JS, Smith JM, Neibergs HL. 2011. Identification of loci associated with tolerance to Johne’s disease in Holstein cattle. Animal Genetics 42(1), 28-38. https://doi.org/10.1111/j.1365-2052.2010.020.76.x