A review study on Uncoupling Proteins UCP2 and UCP3 and their potential role to disorders
Paper Details
A review study on Uncoupling Proteins UCP2 and UCP3 and their potential role to disorders
Abstract
UCP2 and UCP3 (uncoupling proteins 2 and 3) are mitochondrial proteins; have been identified as homologues to uncoupling protein 1 that may control the energy lavishing in the synthesis of ATP. The UCP2 has been expressed widely in the different organs of body; respect to it, the UCP3 has been expressed only in muscles attached to skeleton and very less in BAT. They are important in diminishing the production of mitochondria in ROS, insulin regulation, indeed thermogenesis and obesity. Uncoupling proteins 2 and 3 may not effectuate the thermogenesis of whole body in mammals; in place they have variety of physiological role in the adjustment of fatty acid redox capacity in fasting and starving, protection from imbalance of free radicals and other harmful effects inside the body through neutralization. Although many scholars have devoted their efforts to demonstrate the mechanism of UCP2 and UCP3, little information is available about their physiological role. The possible data acquired about UCP2 and UCP3 is comprised in present review.
Affourtit, Charles and Martin D Brand. 2008. On the role of uncoupling protein-2 in pancreatic beta cells. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1777, 973-979.
Andrews, Zane B, Zhong-Wu Liu, Nicholas Walllingford, Derek M, Erion, Erzsebet Borok, Jeffery M, Friedman, Matthias H, Tschöp M, Shanabrough G, Cline G, Shulman I, Coppola A. 2008. UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals. Nature 454, 846-851. https://doi.org/10.1038/nature07181
Azzu, Vian and Martin D Brand. 2010. The on-off switches of the mitochondrial uncoupling proteins. Trends in biochemical sciences 35, 298-307. https://doi.org/10.1016/j.tibs.2009.11.001
Azzu, Vian, Charles Affourtit, Eamon P, Breen, Nadeene Parker and Martin, Brand D. 2008. Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1777, 1378-1383.
Borecký, Jiri, Ivan G, Maia and Paulo Arruda. 2001. Mitochondrial uncoupling proteins in mammals and plants. Bioscience reports 21, 201-212. https://doi.org/10.1023/a:1013604526175
Boss, Olivier, Jean-Paul Giacobino and Patrick Muzzin. 1998. Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13. Genomics 47, 425-426. https://doi.org/ 10.1006/geno.1997.5135
Boss, Olivier, Patrick Muzzin and Jean-Paul Giacobino. 1998. The uncoupling proteins, a review. European Journal of Endocrinology 139, 1-9. https://doi.org/10.1530/eje.0.1390001
Boss, Olivier, Sonia Samec, Ariane Paoloni-Giacobino, Colette Rossier, Abdul Dulloo, Josiane Seydoux, Patrick Muzzin and Jean-Paul Giacobino. 1997. Uncoupling protein3: a new member of the mitochondrial carrier family with tissue specific expression. FEBS letters 408, 39-42. https://doi.org/10.1016/s0014-5793(97)00384-0
Bouchard, Claude, Louis Pérusse, Yvon C, Chagnon, Craig Warden and Daniel Ricquier. 1997. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Human molecular genetics 6, 1887-1889. https://doi.org/10.1093/hmg/6.11.1887
Bouillaud, Frédéric, Serge Raimbault and Daniel Ricquier. 1988. The gene for rat uncoupling protein: complete sequence, structure of primary transcript and evolutionary relationship between exons. Biochemical and biophysical research communications 157, 783-792. https://doi.org/10. 1016/ s0006-291x(88)80318-8
Clapham, John C, Jonathan RS, Arch, Helen Chapman and Andrea Haynes. 2000. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406, 415-418. https://doi.org/10.1038/35019082
Derdak, Zoltan, Nicholas M, Mark, Guido Beldi, Simon C, Robson, Jack R, Wands and György Baffy. 2008. The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer research 68, 2813-2819. https://doi.org/10. 1158/ 0008-5472.can-08-0053
Elbein, Steven C, Mark Leppert and Sandra Hasstedt. 1997. Uncoupling protein 2 region on chromosome 11q13 is not linked to markers of obesity in familial type 2 diabetes. Diabetes 46, 2105-2107. https://doi.org/10.2337/diab.46.12.2105
Fisler, Janis Craig S, Warden H. 2006. Uncoupling proteins, dietary fat and the metabolic syndrome. Nutrition & metabolism 3, 1-38. https://doi. org/10.1186/1743-7075-3-38
Fleury, Christophe, Maria Neverova, Sheila Collins, Serge Raimbault, Odette Champigny, Corinne Levi-Meyrueis, Frederic Bouillaud, MF, Seldin, RS, Surwit, Daniel Ricquier CH, Warden. 1997. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature genetics 15, 269-272. https://doi.org/10.1038/ng0397-269
Freake, Hedley C. 1998. Uncoupling proteins: beyond brown adipose tissue. Nutrition reviews 56, 185-189. https://doi.org/10.1111/j.1753-4887.1998.tb06136.x
Gimeno, Ruth E, Marlene Dembski, Xun Weng, Nanhua Deng, Andrew W, Shyjan, Carlos J Gimeno, Francois Iris, Stephan J, Ellis, Elizabeth A, Woolf and Louis, Tartaglia A. 1997. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46, 900-906. https://doi.org/10.2337/diabetes.46.5.900
Gong, Da-Wei, Yufang He, Michael Karas and Marc Reitman. 1997. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin. Journal of Biological Chemistry 272, 24129-24132. https://doi.org/10.1074/jbc.272.39.24129
Jarmuszkiewicz, Weislawa, Claudine M, Sluse-Goffart, Lilla Hryniewiecka and Francis, Sluse E. 1999. Identification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii. Journal of Biological Chemistry 274, 23198-23202. https://doi.org/10.1074/jbc.274.33.23198
Koyama, Kazunori, Guoxun Chen, May-Yun Wang, Young Lee, Michio Shimabukuro, Christopher, Newgard B, Roger, Unger H. 1997. β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 46, 1276-1280. https://doi.org/10.2337/ diabetes.46.8.1276
Krauss, Stephan, Chen-Yu Zhang and Bradford, Lowell B. 2005. The mitochondrial uncoupling-protein homologues. Nature reviews Molecular cell biology 6, 248-261. https://doi.org/10.1038/nrm1592
Ledesma, Amalia, Mario García de Lacoba and Eduardo Rial. 2002. The mitochondrial uncoupling proteins. Genome biology 3, reviews 3015-1. https://doi.org/10.1186/gb-2002-3-12-reviews3015
Nègre-Salvayre, Anne C, Hirtz G, Carrera R, Cazenave M, Troly, Robert Salvayre, Luc Pénicaud and Louis Casteilla. 1997. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. The FASEB Journal 11, 809-815. https://doi.org/10.1096/fasebj.11.10.9271366
Nicholls, David G, Eduardo Rial. 1984. Brown fat mitochondria. Trends in Biochemical Sciences 9, 489-491. https://doi.org/10.1016/0968-0004(84)90
Nicholls, David G, Vibeke Bernson SM, Gillian Heaton M. 1978. The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation. In Effectors of Thermogenesis Birkhäuser Basel 89-93. https://doi.org/10.1007/ 978-3-0348-5559-4_9
Nilsson, Thomas, Vera Schultz, Per-Olof Berggren, Barbara E, Corkey and Tornheim Tornheim. 1996. Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic β-cells. Biochemical journal 314, 91-94. https://doi.org/10.104.
Pecqueur, Claire, Marie-Clotilde Alves-Guerra, Chantal Gelly, Corinne Lévi-Meyrueis, Elodie Couplan, Sheila Collins, Daniel Ricquier, Frédéric Bouillaud and Bruno Miroux. 2001. Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. Journal of Biological Chemistry 276, 8705-8712. https://doi.org/ 10.1074/jbc.m006938200
Ricquier, Daniel and Frédéric Bouillaud. 2000. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochemical Journal 345, 161-179. https://doi.org/10.1042/bj3450161
Shimabukuro, Michio, Yan-Ting Zhou, Young Lee and Roger Unger H. 1997. Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats. Biochemical and biophysical research communications 237, 359-361. https://doi.org/ 10.1006/ bbrc.1997.7140
Soejima, Aki, Kimiko Inoue, Daisaku Takai, Motohisa Kaneko, Hisamitsu Ishihara, Yoshitomo Oka and Jun-Ichi Hayashi. 1996. Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6. Journal of Biological Chemistry 271, 26194-26199. https://doi.org/10. 1074/jbc.271.42.26194
Solanes, Gemma, Antonio Vidal-Puig, Danica Grujic, Jeffery S, Flier and Bradford B Lowell. 1997. The human uncoupling protein-3 gene Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.Journal of Biological Chemistry272, 25433-25436.
Urhammer SA, Dalgaard LT, Sørensen TIA, Møller AM, Andersen T, Tybjaerg-Hansen A, Hansen T, Clausen JO, Vestergaard H, Pedersen O. 1997. Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance. Diabetologia 40, 1227-1230. https://doi.org/10.1007/s001250050811
Vidal-Puig, Antonio, Gemma Solanes, Danica Grujic, Jeffery S, Flier and Bradford Lowell B. 1997. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochemical and biophysical research communications 235, 79-82. https://doi.org/10.1006/bbrc.1997.6740
Zhou, Yan-Ting, Michio Shimabukuro, Kazunori Koyama, Young Lee, May-Yun Wang, Falguni Trieu, Christopher B, Newgard and Roger Unger H. 1997. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proceedings of the National Academy of Sciences 94, 6386-6390. https://doi.org/10.1073/ pnas.94.12.6386
Sapna Waheed Memon, Javed Ahmed Ujan, Sadaf Jumani, Majida Narejo, 2018. A review study on Uncoupling Proteins UCP2 and UCP3 and their potential role to disorders. Int. J. Biosci., 12(3), 162-169.
Copyright © 2018 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.