A review study on Uncoupling Proteins UCP2 and UCP3 and their potential role to disorders

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Research Paper 01/03/2018
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A review study on Uncoupling Proteins UCP2 and UCP3 and their potential role to disorders

Sapna Waheed Memon, Javed Ahmed Ujan, Sadaf Jumani, Majida Narejo
Int. J. Biosci.12( 3), 162-169, March 2018.
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UCP2 and UCP3 (uncoupling proteins 2 and 3) are mitochondrial proteins; have been identified as homologues to uncoupling protein 1 that may control the energy lavishing in the synthesis of ATP. The UCP2 has been expressed widely in the different organs of body; respect to it, the UCP3 has been expressed only in muscles attached to skeleton and very less in BAT. They are important in diminishing the production of mitochondria in ROS, insulin regulation, indeed thermogenesis and obesity. Uncoupling proteins 2 and 3 may not effectuate the thermogenesis of whole body in mammals; in place they have variety of physiological role in the adjustment of fatty acid redox capacity in fasting and starving, protection from imbalance of free radicals and other harmful effects inside the body through neutralization. Although many scholars have devoted their efforts to demonstrate the mechanism of UCP2 and UCP3, little information is available about their physiological role. The possible data acquired about UCP2 and UCP3 is comprised in present review.


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