A study of high-sensitivity C-reactive protein in relation to respiratory symptoms in mild to moderate asthma

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Research Paper 01/10/2011
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A study of high-sensitivity C-reactive protein in relation to respiratory symptoms in mild to moderate asthma

Mojtaba Izadi, Somayeh Bakhshi, Payman Abrifam, Davood Khorshidi
Int. J. Biosci.1( 5), 83-88, October 2011.
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To determine the role high-sensitivity C-reactive protein (CRP) as a inflammation cytokine in the severity of asthma, a resting spirometry test and fasting blood sampling was performed in 42 middle-aged males with mild to moderate severity of asthma for measuring serum CRP and respiratory functional. Also, a total 33 healthy males participated in study as control group. Pearson correlations were used to establish the relationship between serum CRP concentrations with spirometry markers in asthma patients. Serum CRP concentration in asthmatic patients was significantly higher than healthy subjects. Serum CRP correlated negatively with FEV1 (p = 0.021), FVC (p = 0.026) and FEV1/FVC (p = 0.034). Based on our results, we can say asthma is a inflammation disorder and these date support the hypothesis that the measurement of serum levels of hs-CRP may be useful tool for detecting systemic inflammation in asthma.


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