A study on central line associated bloodstream infections (CLABSI) in hemodialysis patients at a Tertiary care Hospital

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Research Paper 05/11/2022
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A study on central line associated bloodstream infections (CLABSI) in hemodialysis patients at a Tertiary care Hospital

G. Tejaswini, V. Sudha Rani
Int. J. Micro. Myco.15( 5), 19-24, November 2022.
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Central line catheters are the main source of vascular access in the initial stages of hemodialysis for most of the chronic kidney disease patients. Their immunocompromised state makes them more vulnerable for catheter associated nosocomial infections. The present study was aimed to determine the incidence, causative organisms, antibiogram and the role of bundle care in the prevention of these infections. It is a cross sectional study carried out over a period of 6 months in a tertiary care hospital which included 70 adults (18-60 years) undergoing hemodialysis and suspected of septicaemia. Two blood samples 5ml each were collected from each patient, one from peripheral line and other from central line, transported and processed by standard bacteriological methods. Antibiotic susceptibility was determined by Kirby Bauer disk diffusion method. Incidence of CLABSI was 22.5% with rate being 11. 49 episodes per 1000 catheter days. Incidence was more in adults between the age of 30 to 39 and there was male predominance. S. aureus was the predominant isolate. The other isolates were Klebsiella species, Acinetobacter and Pseudomonas. Gram positive organisms were sensitive to teicoplanin, linezolid, Clindamycin, Vancomycin and resistant to Azithromycin. Gram negative organisms were 100% sensitive to Imipenem and Cefepime and 100% resistant to Ampicillin. CLABSI are a major cause of hospitalization and mortality in hemodialysis patients. Since CVCs are increasingly being used every dialysis unit should have an infection surveillance program to facilitate identification of catheter related infections and timely interventions to reduce infection rates and improve patient clinical outcomes.


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