Accuracy of cervico vaginal fetal fibronectin test in predicting risk of spontaneous preterm birth

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Research Paper 01/07/2019
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Accuracy of cervico vaginal fetal fibronectin test in predicting risk of spontaneous preterm birth

Maysoon Sharief, Saha Mahmood
Int. J. Biomol. & Biomed.10( 1), 1-6, July 2019.
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Preterm delivery is the leading cause of neonatal mortality. One of the best predictors to assess the risk of preterm labour (PTB) is by measuring fetal fibronectin (fFN) in cervico vaginal secretion after 26 weeks of pregnancy. The aim is to evaluate the diagnostic accuracy of qualitative cervico vaginal fFN in symptomatic women and asymptomatic high risk women during antenatal care. Prospective study which was conducted in Basrah Maternity and Child Hospital. It included 106 pregnant women at gestational age more than 26 weeks who had uterine contraction with or without pervious risk factors for PTB. Cervico vaginal fluid sampling was undertaken from all women included in the study after the age of 26 weeks of gestation and qualitative fFN assessment was done with 50ng/ml is the cut off point for positivity. As regard qualitative fFN assessment for predicting of PTB sensitivity, specificity, PPV, NPV, were 71%, 87%, 40.50%, 94% respectively in symptomatic women. While in asymptomatic women with previous high risk had 26% sensitivity, 84% specificity, 32% PPV, and 87% NPV. Qualitative assessment of fFN in cervico vaginal fluid is good predictive marker in detecting of PTB.


Abbott D, Hezelgrave N, Seed P, Norman J, David A, Bennett P, et al. 2015. Quantitative fetal fibronectin to predict preterm birth in asymptomatic women at high risk. Obstetrics and Gynecology 125, 1168-1176.

American College of Obstetricians and Gynecologists. Preterm (premature) labour and birth[Internet]. Washington, DC: American College of Obstetricians and Gynecologists; 2016 [cited 2018 August13]. Available from: http://www.

Bennett P. Preterm Labour. 2018. In Dewhurst’s Textbook of Obstetrics and Gynecology, 9th edition, 2018. Edmonds DK, Lees C, Bourne T. Wiley Blackwell, London, UK. P 387-412.

Foster C, Shennan AH. 2014. Fetal fibronectin as a biomarker of preterm labor: a review of the literature and advances in its clinical use. Biomarker Medicine 8, 471-484.

Goldenberg RI, Iams JD, Mercer BM, Meis PJ, Moawad A, Das A, et al. 2001. The Preterm Prediction Study: toward a multiple-marker test for spontaneous preterm birth. American Journal of Obstetrics and Gynecology 185, 643-651.

Hezelgrave NL, Shennan AH, David AL. 2015. Tests to predict imminent delivery in threatened preterm labour. British Medical Journal 350, 2183-2185.

Honest H, Bachmann LM, Gupta JK, Klejinen J, Khan KS. 2002. Accuracy of cervical vaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: Systematic review. British Medical Journal 325, 301-303.

Iams JD. 2003. Prediction and early detection of preterm labor. High-Risk Pregnancy Series: An Expert’s View 101(2), 402-412.

Kuhrt K, Hezelgrave N, Foster C, Seed PT, Shernnan AH. 2016. Development and validation of a tool incorporating quantitative fetal fibronectin to predict spontaneous preterm birth in symptomatic women. Ultrasound Obstetrics and Gynecology 47, 210-216.

Leitich H, Kaider A. 2003. Fetal fibronection-How useful is it in prediction of preterm birth? British Journal of Obstetrics and Gynecology 110, 66-70.

Lockwood CJ, Senyel AE, Dische MR, Casal D, Shah KD, Thung SN, et al. 1991. Feta fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. The New England Journal of Medicine 325(5), 669-674.

Offiah I, O’Donoghue K, Kenny L. 2012. Clinical Risk factors for preterm birth. INTECH Open Access Publisher. p73-88.

Roman AS, Koklanaris N, Paidas MJ, Mulholland J, Levitz M, Rebarber A. 2005. “Blind” vaginal fetal fibronectin as a predictor of spontaneous preterm delivery. Obstetrics and Gynecology 105, 285-289.