Acute and recovery responses of glucose and insulin resistance to running test in obese individuals

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Research Paper 01/09/2013
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Acute and recovery responses of glucose and insulin resistance to running test in obese individuals

Shahedi Valiollah, Bananaeifar Abdolali, Ghanei Babak, Kalhor Hossein
Int. J. Biosci.3( 9), 318-323, September 2013.
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Accumulating evidence indicates that obesity and overweight are associated with insulin resistance; however, the precise mechanisms of any association between them have not yet been established. This study is designed to evaluate acute and recovery response of insulin resistance to an exercise test in adult obese men. For this purpose, twenty sedentary healthy obese men aged 37 – 44 years, 30 – 35 kg/m2 of BMI were enrolled for participation in this study. Venous blood samples were collected before, 0, 1 and 24 hours after single bout running test for 45 min in order to measuring glucose and insulin. Insulin and glucose levels were used for the homeostasis model assessment of insulin resistance. Repeated measures ANOVA method was used to analysis. Glucose concentration decreased immediately and 1 hour after exercise test and return to baseline levels after 24 hours. Serum insulin and insulin resistance decreased immediately after exercise, but return to baseline levels after 1 hour. Based on these data, we can say 45 min running for one session is associated with acute decreased in glucose and insulin resistance not recovery response in obese men.


Bell LM, Watts K, Siafarikas A. 2007. Exercise Alone Reduces Insulin Resistance in Obese Children Independently of Changes in Body Composition. Journal of Clinical Endocrinology & Metabolism 92(11), 4230–5.

Berggren JR, Hulver MW, Houmard JA. 2005. Fat  as  an  endocrine  organ:  influence  of  exercise. Journal of Applied Physiology 99, 757–764.

Choi SB, Jang JS, Park S. 2005. Estrogen and exercise may enhance beta-cell function and mass via IRS2 induction in ovariectomized diabetic rats. Endocrinology 146, 4786–4794.

Cockram CS. 2000. The epidemiology of diabetes mellitus in the Asia-Pacific region. Hong Kong Medical Journal 6, 43–52.

Dela F, Mikines KJ, Tronier B, Galbo H. 1990. Diminished arginine-stimulated insulin secretion in trained men. Journal of Applied Physiology 69, 261– 267.

Dela F, von Linstow ME, Mikines KJ, Galbo H. 2004. Physical training may enhance beta-cell function  in  type  2  diabetes.  American  Journal  of Physiology  –  Endocrinology  and  Metabolism  287, 1024–1031.

Heled Y, Shapiro Y, Shani Y, Moran DS, Langzam L, Barash V, Sampson SR, Meyerovitch J. 2004. Physical exercise enhances hepatic insulin signaling and inhibits phosphoenolpyruvate carboxykinase activity in diabetes-prone Psammomys obesus. Metabolism 53, 836–841.

Kim J, Wei Y, James R. 2008. Role of Mitochondrial Dysfunction in Insulin Resistance. American Heart Association 102, 401-414.

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28(7), 412-419.

Nandi A, Kitamura Y, Kahn CR, Accili D. 2004. Mouse  models  of  insulin  resistance.  Physiological Reviews 84(2), 623-47.

Park S, Hong SM, Lee JE, Sung SR. 2007. Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic B- cell function and mass through IRS2 in diabetic rats. Journal of Applied Physiology 103(5), 1764-71.

Perrini S, Henriksson J, Zierath JR, Widegren U. 2004. Exercise-induced protein Kinase C isoform-specific activation in human skeletal muscle. Diabetes 53, 21–24.

Perseghin G, Lattuada G, De Cobelli F, Ragogna F, Ntali G, Esposito A, Belloni E, Canu T, Terruzzi I, Scifo P, Del Maschio A, Luzi L. 2007. Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care 30, 683–688.

Rubin DA, McMurray RG, Harrell JS, Hackney AC, Thorpe DE, Haqq AM. 2008. The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise. Metabolism 57(5), 683-90.

Saltiel AR, Kahn CR. 2001. Insulin signalling and the regulation of glucose and lipidmetabolism. Nature 414, 799–806.

Sheu WH, Chang TM, Lee WJ, Ou HC, Wu CM, Tseng LN ET AL. 2008. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring) 16(5), 1033-8.

Steven  E,  Laura  H,  Afia  N.  2007.  Obesity, Inflammation, and Insulin Resistance. Gastroenterology 132, 2169–2180.

Tang Z, Yuan L, Gu C, Liu Y, Zhu L. 2005. Effect of exercise on the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats. Journal of Huazhong  University  of  Science  and  Technology 25(2), 191-3, 201.

Yassine  HN,  Marchetti  CM,  Krishnan  RK. 2009. Effects of exercise and caloric restriction  on insulin resistance and cardiometabolic risk factors in older  obese  adults  –  Arandomized  clinical  trial. Journal of Genontolog 64, 90 –5.