Acute response of serum leptin to short single bout exercise in patients with moderate asthma

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Research Paper 01/06/2011
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Acute response of serum leptin to short single bout exercise in patients with moderate asthma

Eizadi Mojtaba, Kohandel Mahdi, kasbparast JR Mehdi, Sarshin Amir
J. Bio. Env. Sci.1( 3), 27-34, June 2011.
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Recently, it has been hypothesized that leptin levels is increased during allergic reactions in the airway and may be a role in asthma prevalence, but the mechanisms underlying this response are a matter of some debate. The objective of this study was to evaluate the effect a stepwise incremental bicycle test on a bicycle erogometer on serum leptin in asthma patients and to determine its changes role in response to exercise on respiratory functional in these patients. For this purpose, twenty middle-aged males with moderate asthma participated in this study by accessible sampling. Pre and post training blood samples and respiratory functional test were performed in order to measuring serum leptin and spirometry parameters in all patients. Pre- to post training changes were determined by two-tailed t tests. The bivariate associations between changes in leptin concentrations with respiratory function were examined with the Pearson rank correlation analysis. No significant differences were found in serum leptin by cycling exercise with compared to baseline (p ≥ 0.05). Compared to pre-exercise, the spirometric marker levels as FEV1 and FVC increased significantly after cycling exercise (p ˂ 0.05). We found no evidence that changes in serum leptin were associated with changes in each spirometry markers in response to exercise test (p ≥ 0.05). Based these data, we can say, exercise for a session can not affect serum leptin in asthma patients and the change in serum leptin by short-time exercise is not associated with respiratory functional in these patents.


Baltaci AK, Ozyurek K, Mogulkoc R, Kurtoglu E, Ozkan Y, Celik I. 2003. Effects of zinc deficiency and supplementation on the glycogen contents of liver and plasma lactate and leptin levels of rats performing acute exercise. Biological Trace Element Research 96, 227-236.

Beuther DA, Weiss ST, Sutherland ER.2006. Obesity  and  asthma.  Am  J  Respir  Crit  Care  Med 174(2), 112-9.

Bouassida A, Zalleg D, Zaouali M. 2004. Effets d’un exercice supra-maximal sur les concentrations de la leptine plasmatique. Sci Sports 19, 136–8.

Buyse M, Aparicio T, Guilmeau S, Goiot H, Sobhani I, Bado A. 2004. Paracrine actions of the stomach-derived leptin. Medecine Sciences (Paris) 20, 183-188.

Cioffi JA, Van Blerkom J, Antczak M, Shafer A, Wittmer S, Snodgrass HR. 1997. The expression of leptin and its receptors in preovulatory human follicles. Molecular Human Reproduction 3, 467-472.

Erel F, Gulec M, Kartal O, Caliskaner Z, Ozturk S, Yaman H et al. 2007. Serum leptin levels and lipid profiles in patients with allergic rhinitis and mild asthma. Allergol Immunopathol (Madr) 35(6), 232-8.

Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S et al. 2007. Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A 104(44), 17358-63.

Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL. 1999. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48, 839–847.

Green ED, Maffei M, Braden VV. 1995. The human obese gene: RNA expression pattern and mapping on the physical, cytogenetic and genetic of chromosome 7. Genome Research 5, 5-12.

Guler N, Kırerleri E, Ones U , Salmayenli N, Tamay Z. 2003. High serum leptin levels in asthmatic children. J Allergy Clin Immunol 111, 268.

Guler N, Kirerleri E, Ones U. 2004. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol114, 254–9.

Gurkan F, Atamer Y, Ece A, Kocyigit Y, Tuzun H, Mete N. 2004. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol 93(3), 277-80.

Hilda Segura N, Hernández L, Velázquez C, Rodríguez J, Murillo E. 2007. Asthma and obesity: related inflammatory diseases. Rev Alerg Mex 54(1), 24-8.

Højbjerre L, Rosenzweig M, Dela F, Bruun JM, Stallknecht B. 2007. Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects. Eur J Endocrinol. 157(5), 613-23.

Huang L, Li C. 2000. Leptin: a multifunctional hormone. Cell Res 10, 81-92.

Izquierdo M, Häkkinen K, Ibañez . 2001. Effects of strength training on muscle power and serum hormones in middle-aged and older men. J Appl Physiol 90, 1497–1507.

Jurimae J, Jurimae T.2005. Leptin responses to short term exercise in college level male rowers. Br J Sports Med 39, 6–9.

Kim KW, Shin YH, Lee KE, Kim ES, Sohn MH, Kim KE. 2008. Relationship between adipokines and manifestations of childhood asthma. Pediatr Allergy Immunol. [Epub ahead of print].

Margetic S, Gazzo;a GG, Pegg RA. 2002. Leptin: A review of its peripheral action and interactions. Int. J. Obes. Relat. Metab. Disord. 26, 1407-1433.

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

Neveu WA, Allard JL, Raymond DM, Bourassa LM, Burns SM, Bunn JY et al. 2010. Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Respir Res. 8 11, 28.

Olive JL, Miller GD. 2001.Differential effects of maximal- and moderate-intensity runs on plasma leptin in healthy trained subjects. Nutrition 17, 365–9.

Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, et al. 2001. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med 33, 95-102.

Pischon T, Rimm EB. 2006. Adiponectin: a promising marker for cardiovascular disease. Clin Chem 52, 797–799.

Sari R, Balci MK, Balci N. 2007. Acute effect of exercise on plasma leptin level and insulin resistance in obese women with stable caloric intake. Endocr Res 32, 9–17.

Settin A, Zedan M, Farag M, Ezz El Regal M, Osman E. 2008. Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in asthmatic children. Indian J Pediatr 75(10), 1019-23.

Shore SA, Rivera-Sanchez YM, Schwartzman IN, Johnston RA. 2003. Responses to ozone are increased in obese mice. J Appl Physiol 95, 938-45.

Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA. 2005. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 115(1), 103-9.

Smith-Kirwin SM, O’Connor DM, De Johnston J, Lancey ED, Hassink SG, Funanage VL. 1998. Leptin expression in human mammary epithelial cells and breast milk. The Journal of clinical Endocrinology & Metabolism 83, 1810-1813.

Tsuchiya T, Shimizu H, Horie T, Mori M. 1999. Expression of leptin receptor in lung: leptin as a growth factor. Eur J Pharmacol 365, 273-9.

Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CLet al. 2001. Weight reduction increases plasma levels of an adipose- derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 86(8), 3815-9.

Zaccaria M, Ermolao A, Roi GS. 2002. Leptin reduction after endurance races differing in duration and energy expenditure. Eur J Appl Physiol 87, 108–11.