Adiponectin and insulin resistance responses to aerobic training in males with abdominal obesity

Paper Details

Research Paper 01/12/2011
Views (296) Download (4)
current_issue_feature_image
publication_file

Adiponectin and insulin resistance responses to aerobic training in males with abdominal obesity

Eizadi Mojtaba, Khorshidi Davood, Dooaly Hussein, Samarikhalaj Hamidreza
J. Bio. Env. Sci.1( 6), 228-235, December 2011.
Certificate: JBES 2011 [Generate Certificate]

Abstract

Accumulating evidence support the adiponectin role in genesis of obesity and insulin resistance. The objective of this study was to evaluate effect a chronic aerobic exercise on serum adiponectin and insulin resistance in obese men. For this purpose, at baseline and after 12 weeks of aerobic exercise training, blood samples were taken in order to measuring serum adiponectin, glucose, and insulin in twenty eight in sedentary obese healthy males that divided to exercise (60 min, 3 days/week for 12 weeks, n=14) and control (no training. n=14) groups matched for age and BMI by randomly. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance formula derived from fasting insulin and glucose levels. Pre- and post exercise independent variables were compared using a paired-samples t-test. Significance was accepted at P < 0.05. No significant differences were found in serum adiponectin and insulin resistance at the end of the 3-month exercise program with compared to baseline (p≥0.05). Fasting glucose concentrations were significantly decreased by aerobic training program in exercise group (P=0.01). Despite to some previous study, in present study, we conclude that aerobic exercise training is not associated with improve in adiponectin or insulin resistance. Decreased glucose concentration is likely due to the other exercise induced hormonal changes.

VIEWS 6

Ajuwon KM, Spurlock ME. 2005. Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol 288, 1220–1225.

Aldhahi W, Hamdy O. 2003. Adipokines, inflammation, and the endothelium in diabetes. Curr Diab Rep 3, 293–298.

Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al. 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 257, 79–83.

Berg AH, Scherer PE. 2005. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96, 939–949.

Bluher  M,  Bullen  JW  Jr,  Lee  JH.  2006. Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. J Clin Endocrinol Metab 91, 2310–2316.

Boudou P, Sobngwi E, Mauvais-Jarvis F, Veviau P, Gautier JF. 2003. Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adipocity and improved insulin sensitivity in type 2 diabetic men. Eur J Endocrinol 149, 421–424.

Bruun JM, Helge JW, Richelsen B, Stallknecht B. 2006. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 290, 961–967.

de Salles BF, Simão R, Fleck SJ, Dias I, Kraemer-Aguiar LG, Bouskela E. 2010. Effects of resistance training on cytokines. Int J Sports Med 31(7), 441-50.

Fasshauer  M,  Kralisch  S,  Klier  M.  2003. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 301, 1045–1050.

Fruebis J, Tsao TS, Javorschi S. 2001. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98, 2005–2010.

Havel PJ. 2002. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol 13, 51- 9.

Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, et al. 2000. Plasma concentrations of a novel, adipose-specific protein, adiponectin in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20, 1595–9.

Huang H, Iida KT, Sone H, Ajisaka R. 2007. The regulation of adiponectin receptors expression by acute exercise in mice. Exp Clin Endocrinol Diabetes 115(7), 417-22.

Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz S. 2002. Adiponectin is not altered with exercise training despite enhanced insulin action. AmJ Physiol 283, 861–865.

Ishii T, Yamakita T, Yamaguchi K, FukumotoM, Yoshioka K, HosoiM. 2002. Plasma adiponectin levels are associatedwith insulin sensitivity improved by exercise training in type 2 diabetic patients. Diabetes 51(Suppl 2), 248.

Kim K-Y, Kim JK, Han SH. 2006. Adiponectin is a negative regulator of NK cell cytotoxicity. J Immunol 176, 5958–5964.

KobayashiJ,MuraseY,Asano A. 2006. Effectofwalkingwitha pedometer on serum lipid and adiponectin levels in Japanese middle-aged men. J Atheroscler Thromb 13, 197–201.

Kriketos AD, Gan SK, Pounten AM, Furler SM, Chisholm DJ, Campbell LV. 2004. Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes Care 27, 629–630.

Lara-Castro C, Luo N, Wallace P, Klein RL, Garvey WT. 2006. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 55, 249–259.

Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y & Matsubara K. 1996. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochemical and Biophysical Research Communications 221, 286–289.

Matsuzawa Y. 2005. White adipose tissue and cardiovascular disease. Best Pract Res Clin Endocrinol Metab 19, 637–647.

Meilleur KG, Doumatey A, Huang H, Charles B, Chen G, Zhou J. 2010. Circulating adiponectin is associated with obesity and serum lipids in West Africans. J Clin Endocrinol Metab 95(7), 3517-21.

O’Leary VB, Jorett AE, Marchetti CM. 2007. Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin resistant adults. Am J Physiol Endocrinol Metab 293(1), 421–427.

Ouchi N, Kihara S, Arita Y. 1999. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100, 2473–2476.

Pajvani UB, Du X, Combs TP. 2003. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem 278, 9073– 9085.

Pedersen BK, Steensberg A, Fischer C, Keller C, Ostrowski K, Schjerling P. 2001. Exercise and cytokines with particular focus on muscle-derived IL-6. Exerc Immunol Rev 7, 18–31.

Peti A, Juhasz A, Kenyeres P, Varga Z, Seres I, Kovacs GL. 2010. Relationship of adipokines and non-esterified fatty acid to the insulin resistance in nondiabetic individuals. J Endocrinol Invest [Epub ahead of print].

Rosenbaum M, Nonas C, Weil R. 2007. School-based intervention acutely improves insulin sensitivity and decreases inflammatory markers and body fatness in junior high school students. J Clin Endocrinol Metab 92, 504–508.

Salmenniemi U, Ruotsalainen E, Pihlajamaki J. 2004. Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation 110, 3842–3848.

Scherer PE,Williams S, Fogliano M, Baldini G & Lodish HF. 1995. A novel serum protein similar to C1q, produced exclusively in adipocytes. Journal of Biological Chemistry 270, 26746–26749.

Sell H, Dietze-Schroeder D, Eckardt K, Eckel J. 2006. Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone. Biochem Biophys Res Commun 343, 700–706.

Shi JH, Du WH, Liu XY, Fan YP, Hu XL, Zhou HY. 2010. Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats. Steroids [Epub ahead of print].

Simpson KA, Singh MA. 2008. Effects of exercise on adiponectin: a systematic review. Obesity (Silver Spring) 16(2), 241-56.

Tang Z, Yuan L, Gu C, Liu Y, Zhu L. 2005. Effect of exercise on the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats. J Huazhong Univ Sci Technolog Med Sci 25(2), 191-3, 201.

Tsao T-S, Murrey HE, Hug C, Lee DH, Lodish HF. 2002. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 277, 29359–29362.

Vivian V, Michael CR, Gary S. 2007. Circulating adiponectin and adiponectin receptor expression in skeletal muscle: effects of exercise. Diabetes Metab Res Rev 23, 600–611.

Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE. 2001. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86, 1930–5.

Yatagai T, Nishida Y, Nagasaka S, Nakamura T, Tokuyama K, Shindo M. 2003. Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men. Endocr J 50, 233–238.

Yokoyama H, Emoto M, Araki T. 2004. Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes. Diabetes Care 27, 1756–1758.

Zeng Q, Isobe K, Fu L. 2007. Effects of exercise on adiponectin and adiponectin receptor levels in rats. Life Sci 80, 454–459.