Int. J. Biosci.1(5), 95-101, October 2011
Recently, it has been hypothesized that obesity and increased Body mass index (BMI) is associated with asthma prevalence and cytokines secreted by adipose tissue affects the relationship between them. The objective of this study was to evaluate serum leptin in response to aerobic exercise program in adult asthma patients. For this purpose, thirty two adult obese men with asthma disease divided to experimental and control group by randomly. Measurements of anthropometry, spirometry test and fasting blood sampling in order to serum adiponectin measuring were performed before and after aerobic exercise program in experimental (60 min, 3 days/week for 12 weeks)) and control groups (without exercise). Statistical analysis was performed with the SPSS software version 15.0 using by independent and paired samples T-test. Significance was accepted at P < 0.05. Serum leptin were significantly decreased in response to aerobic exercise program when compared with baseline levels in experimental group (P = 0.033). Anthropometrical indexes were decreased by exercise training, while FEV1 and FVC levels were significantly increased by aerobic exercise program in these patients (P < 0.05). All variables in control group remained didn’t change. Based on this data, it was concluded that exercise training for long time accompanied to loss body weight decreases serum leptin that associated with asthma improvement.
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