Alteration of iron stores in women of reproductive age with HIV in Abidjan (Côte D’ivoire)

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Research Paper 01/08/2012
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Alteration of iron stores in women of reproductive age with HIV in Abidjan (Côte D’ivoire)

Soualio Kamagate, Mathieu N. Bleyere, Leandre K. Kouakou, Kone Mama, Sylvie Doumate, Augustin K. Amonkan, André B. Konan, Duni Sawadogo, Henri Chenal, Etienne E. Ehile, Paul A. Yapo
Int. J. Biomol. & Biomed.2( 2), 1-12, August 2012.
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Abstract

The aim of this study is to evaluate and to characterize the iron metabolism in women of reproductive age infected by VIH in Abidjan. In order to review the iron stores in women of reproductive age, 180 women were recruited in a specialized center for treatment of HIV (ICBRA) based on the criteria for inclusion and exclusion. The mean age of women was 34.7 ± 0.5 years with extremes of 18 and 45 years. These women were classified into two groups of subjects namely 120 HIV positive women and 60 HIV negative as control women. Blood samples were taken from each of the selected women. Assays of various biological indicators (haematological and biochemical parameters) assessment of iron status were performed by different kits adequate for the automatic COBAS INTEGRA 400 Plus. The results of our investigations have demonstrated that all the searched biological has been degraded in enrolled women. Indeed our study found that for all subjects 79.4 % of women reported an abnormal iron status namely 71.7 % and 83.3 % respectively in control women and women with HIV. Abnormal iron status consisted of iron deficiency, iron deficiency anaemia, inflammatory anaemia and inflammatory anaemia associated with iron deficiency. Among the observed various components of iron status, inflammatory anaemia revealed the high prevalence rates in both groups of subjects (46.7 % vs 67.5 %). Our findings have then indicated that HIV infection has dramatically altered iron stores in women of reproductive especially those living with HIV/AIDS.

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