An Evaluation of dark sesame seeds versus white sesame on blood glucose, oxidative stress markers, and kidney function in streptozotocin-induced diabetic rats
Paper Details
An Evaluation of dark sesame seeds versus white sesame on blood glucose, oxidative stress markers, and kidney function in streptozotocin-induced diabetic rats
Abstract
Sesame seeds have been the focus of recent studies due to their potential nutritional value and chemical composition. Forty-eight albino Sprague Dawley rats were divided into 4 groups (12 rats each in group):Group 1—the normal control group, Group 2—the diabetic control group, Group 3—the diabetic group that received the standard diet+15% dark sesame seeds, and Group 4—the diabetic group that received the standard diet+15% white sesame seeds for 6 weeks. Diabetes was induced by a single dose of streptozotocin (60 mg/kg body weight).The levels of blood glucose, (MDA) malondialdehyde, serum creatinine, urea, and Uric acid were statistically lower in G3 and G4 than in G2 (P<0.05). Total antioxidants (TAC) were statistically higher in G3 and G4 than in G2 (P<0.05).No significant difference was found between G3 and G4 in blood glucose. However, G3 showed a significant improvement in MDA and TAC, serum creatinine, urea, and uric acidcompared to G4 (P<0.05). Consuming both dark and white sesame seeds can improve blood glucose, oxidative stress markers and kidney function in streptozotocin-induced diabetic rats. Therefore, sesame seeds area potential protective natural agent against diabetes complications.
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