An in vitro assessment of antibacterial, antifungal and cytotoxic effects of D-glucopyranoside derivatives

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Research Paper 01/06/2018
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An in vitro assessment of antibacterial, antifungal and cytotoxic effects of D-glucopyranoside derivatives

Sarkar MA Kawsar, Md M Rahman, Mariam Islam, Mohammad A Manchur, Imtiaj Hasan, Sultana Rajia
Int. J. Biosci.12( 6), 408-416, June 2018.
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Methyl a-D-glucopyranoside and its twelve acylated derivatives were employed as test chemicals for in vitro antimicrobial functionality test against four human pathogenic bacteria and two phytopathogenic fungi. The evaluation study revealed that the tested chemicals exhibited moderate to good antibacterial and antifungal activities. It was observed that the test chemicals were more effective against fungal phytopathogens than those of the bacterial strains. Encouragingly, a good number of test chemicals exhibited better antimicrobial activity than the standard antibiotics employed. It was also found that selectively acylated derivatives 12 and 13 showed promising inhibition against both Gram-positive and Gram-negative bacteria. That is with the introduction of various acyl groups such as 4-chlorobenzoyl, 2-bromobenzoyl, benzenesulphonyl the antibacterial functionality of the compound 2 increases. The mortality of brine shrimp was found to increase with the increase of concentrations of compounds. It is evident from the results of brine shrimp lethality testing that the test chemicals methyl 2,3,4-tri-O-decanoyl-6-O-octanoyl-α-D-glucopyranoside (5) and methyl 2,3,4-tri-O-lauroyl-6-O-octanoyl-α-D-glucopyranoside (6) showed highest levels of toxicity (i.e., 50% death) indicating its higher mortality and compound 8 displayed the good mortality as 40%.


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