Anti-diabetic, anti-oxidant and anti-hyperlipidemic Activity of Fomitopsis pinicola

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Research Paper 01/02/2020
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Anti-diabetic, anti-oxidant and anti-hyperlipidemic Activity of Fomitopsis pinicola

Muhammad Toseef Zahid, Muhammad Idrees, Usama Farooq, Iram Abdullah, Wei Ying, Asmaa Hussein Zaki, Bao Haiying
Int. J. Biosci.16( 2), 102-112, February 2020.
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Fomitopsis pinicola is a traditional medicinal mushroom used traditionally in the folk medicine of both China and Korea. Polysaccharides are the principal constituents of the fruiting body of F.pinicola. In the current study 3 different extracts were prepared, Polysaccharide Extract (FPP), Alkali Extract (AE) and Chloroform Extract (FPC). F.pinicola extracts anti-diabetic, anti-oxidant and effect on lipid metabolism was checked by using diabetic rats, diabetes induced by streptozotocin (STZ) injection. Five groups were made with nine rats in each group. Parameters were compared with normal control (NC), diabetes control (DC) and FPC treatment groups. With the induction STZ, all diabetic rats showed disturbed fasting blood glucose (FBG), lipid profile and reduced activities of anti-oxidant enzymes such as CAT, SOD, and GSH-Px. Throughout the procedure, DC rat’s body weight deprived, while NC gains bodyweight from beginning to end. Results of the current study revealed that FPP showed superior effect than the other groups, showed more reduced FBG levels and more gain in body weight. With the STZ, serum insulin levels were significantly dropped, FPP also exhibited a rehabilitation effect on serum insulin levels. The biochemical study disclosed that FPP showed significant lipid metabolism than other treatments by declining the levels of TC, TG, and LDL-C with elevated levels of HDL-C. FPP further manifested that CAT, SOD, and GSH-Px activities were increased substantially with dangerous MDA activity suppression. The study endorsed that FPP extract at dose of 300mg/kg/day gave more anti-diabetic, anti-oxidant and anti-lipidemic effects than AE (300mg/kg) and FPC (300mg/kg).


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