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Anti-hyperglycemic and anti-hyperlipidemic effects of Panax ginseng root extract in alloxan induced diabetic rats

Research Paper | November 1, 2018

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Mahrukh Naseem, Nayab Khan, Sajid Khan Tahir, Ghulam Dastagir, Tahseen Ara, Saeed Ahmed Essote

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Int. J. Biosci.13( 5), 27-33, November 2018

DOI: http://dx.doi.org/10.12692/ijb/13.5.27-33


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Diabetes is a third leading life threatening metabolic disorder. Hyperglycemia, dyslipidemia, myocardial infarction and oxidative stress are the major reasons of mortality and morbidity. In the present study we try to evaluate the anti-diabetic and anti-hyperlipidemic properties of Panax ginseng root extract (PG). Wistar-male rats were fed on high fat died for 14-days followed by single intraperitoneal dose of alloxan (130mg/kg BW). Hypoglycemia was prevented by giving glucose solution to drink; finally fasting blood glucose was measured after three-days and rats showed blood glucose level higher than 250mg/dl were included in the study. The rats were divided into four groups: Group-1: included non-diabetic rats, Group-II included diabetic rats without any treatment of PG, Group-III: included diabetic rats receiving 150mg/kg BW of PG, Group-IV: included diabetic rats treated with 250mg/kg BW.  Rats were treated for 14 weeks. ANOVA followed by PLSD Fisher’s test was applied. Body weight and blood glucose was measured on 1st and 14th week. We found a significant reduction in blood glucose and fasting-serum-glucose for group III (306.13±14.14, 273.63±7.90) and for group IV (402.97±12.76; 220.87±9.34) respectively. We found a significant reduction for TC (1.23±0.02), VLDL (0.26±0.01), LDL (0.46±0.01) and significant increased for HDL (0.60±0.01) in Group-IV. Significant increase was found for TG in group III (1.54±0.01) and group IV (1.40±0.01). A significant increased for CAT (19.74±0.58) and significant decrease for MDA (6.56±0.23) was found in group-IV. Furthermore a significant decrease for AST, ALT and creatinine level after treatment. In conclusion PG showed strong anti-hyperglycemic, anti-hypercholesterolemic, anti-hypertriglyceridemic and anti-oxidative properties in dose dependent manner.


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Anti-hyperglycemic and anti-hyperlipidemic effects of Panax ginseng root extract in alloxan induced diabetic rats

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