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Research Paper | January 1, 2014

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Anti-inflammatory cytokine adiponectin in relation to glucose concentration in type II diabetes men

Kaboli Mohamadzaman, Ferizadeh Abbas, Maleki Behnam, Ghazaei Anbaran Yavar

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J. Bio. Env. Sci.4(1), 244-249, January 2014

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Abstract

Adiponectin, a hormone secreted by adipose tissue, plays an important role in the genesis of obesity and type II diabetes. The purpose of this study was to compare adiponectin between type II diabetes and non-diabetes men and to examine the relation of serum adiponectin to glucose concentration in type II diabetic patients. Sedentary adult men with type II diabetes (n=12) or non-diabetes (n=12) men were recruited and underwent testing for measurement of body mass index, body composition and blood levels of adiponectin, insulin and glucose. Fasting blood samples were collected from brachial vein in sitting position of all participants in two groups. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated by fasting insulin and glucose. Serum insulin levels in patients with diabetic showed were significantly higher than those without diabetes symptoms (p = 0.018). Insulin resistance and fasting glucose was also higher in patients than non-diabetes subjects (p = 0.000). There were no significant correlations between serum adiponectin concentrations and fasting glucose in patients (p = 0.38, r = 0.28). Also this anti-inflammatory cytokine was not related to insulin resistance in patients (p = 0.64, r = 0.15). Despite higher serum adiponectin in diabetic patients, but this cytokine can not affect circulation glucose directly.

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Anti-inflammatory cytokine adiponectin in relation to glucose concentration in type II diabetes men

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