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Anti-inflammatory effect of aerobic program in obese men

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Research Paper 01/07/2012
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Anti-inflammatory effect of aerobic program in obese men

Sokhanguei Yahya, hajirasouli Masoud, Afsharmand Zohreh, Behbudi Laleh
J. Bio. Env. Sci.2( 7), 32-37, July 2012.
Certificate: JBES 2012 [Generate Certificate]
Key: ExerciseLoss weightObesityTNF-α

Abstract

The aim of this study was to evaluate the effects of exercise training on serum TNF-α levels obese men. For this purpose, twenty-eight obese sedentary males (age, 41 ± 5 years) were divided to exercise and control groups. Exercise groups underwent a 12-week aerobic exercise program, with a frequency of 3 d/wk and intensity corresponding to 60-80% of individual maximal heart rate and the control subjects were instructed to maintain their habitual activities. Bodyweight and other anthropometrical markers and serum TNF-α were measured before and after the 12 week intervention. Compared to pre-training, the TNF-α level decreased significantly after exercise program in the exercise, but not in the control groups. With aerobic exercise training, subjects in exercise group lost bodyweight, BMI and body fat percentage (p˂0.05). Based on these findings, we can say aerobic exercise is associated with low inflammation cytokine in obese men even.

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Anker SD, Von Haehling S. 2004. Inflammatory mediators in chronic heart failure: an overview. Heart 90, 464-70.

Bruun JM, Helge JW, Richelsen B, Stallknecht B. 2006. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 290, 961–967.

Cesari M, Kritchevsky SB, Baumgartner RN, Atkinson HH, Penninx BW, Lenchik. 2005. Sarcopenia, obesity, and inflammation—results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr 82, 428–434.

Charles P. Lambert, Nicole R. Wright, Brian N. Finck, and Dennis T. Villareal. 2008. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol 105, 473–478.

Cristina R, Riccardo P. 2005. TNF-α as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis. Clinical Science 109, 135–142.

Dandona P, Weinstock R, Thusu K. 1998. Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab 83, 2907-10.

Eizadi M, Khorshidi D, Seyedhoseini MA, Dooaly H. 2011. Increased interleukin-6 is associated with low cardiorespiratory fitness in healthy people. Journal of Biodiversity and Environmental Sciences 1(4), 48-54.

Hotamisligil GS, Shargill NS, Spiegelman BM. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 87-91.

Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444, 860-7.

Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. 1995. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95, 2111–9.

Lang CH, Frost RA, Nairn AC, MacLean DA, Vary TC. 2002. TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation. Am J Physiol Endocrinol Metab 282, 336–347.

Lang CH, Frost RA. 2007. Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha. Metabolism 56, 49–57.

Li YP, Chen Y, John J, Moylan J, Jin B, Mann DL, Reid MB. 2005. TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. FASEB J 19, 362–370.

Mingrone G, Rosa G, Di RP, Manco M, Capristo E, Castagneto M, Vettor R. 2002. Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-alpha reduction and GLUT4 expression enhancement. Int J Obes Relat Metab Disord 26, 1165–1172.

Moschen AR, Molnar C, Geiger S, Graziadei I, Ebenbichler CF, Weiss H. 2010. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor {alpha} expression. Gut 59(9), 1259-64.

Niebauer J. 2000. Inflammatory mediators in heart failure. Int J Cardiol 72, 209-13.

Rotter V, Nagaev I, Smith U. 2003. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278, 45777-84.

Tan Y, Peng X, Wang F, You Z, Dong Y, Wang S. 2006. Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice. J Burn Care Res 27, 226–233.

Tilg H, Moschen AR. 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6, 772-83.

Varady KA, Tussing L, Bhutani S, Braunschweig CL. 2009. Degree of weight loss required to improve adipokine concentrations and decrease fat cell size in severely obese women. Metabolism 58(8), 1096-101.

Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB. 2002. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci 57, 326–332.

Wajant,  H.,  Henkler,  F.  and  Scheurich,  P. 2001. The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. Cell Signalling 13, 389–400.

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