Anti-inflammatory effects of exercise training on Tumor necrosis factor-alpha in obese women
Paper Details
Anti-inflammatory effects of exercise training on Tumor necrosis factor-alpha in obese women
Abstract
In this study, In order to investigate whether 6 weeks aerobic training can lead to improve inflammation profile in obese men. Thirty healthy adult obese women (30 ≤ BMI ≤ 36) divided into exercise or control group by randomly. Aerobic exercise program lasted 6 weeks (3 times weekly). Pre and post training of blood samples were obtained of each participant of two groups after a overnight between 8:00 and 9:00 a.m. Measurements of anthropometry parameters were also performed before and the end of aerobic program. Student’s t-tests for paired samples were performed to determine whether there were signigcant within-group changes in the outcomes. Aerobic training program resulted in significant decrease in weight, BMI, body fat percentage and serum TNF-a in exercise group but these markers remained without change in control group. These findings highlight the importance of anti-inflammatory property of exercise training particularly after weight loss in obese subjects.
Adamopoulos S, Parissis J. Karatzas D. 2002. Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure,” Journal of the American College of Cardiology 39(4), 653–663. http://dx.doi.org/10.1016/S0735-1097(01)01795-8
Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B. 2000. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. Journal of Clinical Endocrinology & Metabolism 85, 3338–3342. http://dx.doi.org/10.1210/jc.85.9.3338
Bradley JR. 2008. TNF-mediated inflammatory disease. Journal of Pathology 214(2), 149-60. http://dx.doi.org/10.1002/path.2287
Bruun JM, Helge JW, Richelsen B, Stallknecht B. 2006. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. American Journal of Physiology – Endocrinology and Metabolism 290, 961–967. http://dx.doi.org/10.1152/ajpendo.00506.2005
Charles P. Lambert, Nicole R. Wright, Brian N. Finck, Dennis T. 2008. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. Journal of Applied Physiology 105, 473–478. http://dx.doi.org/10.1152/japplphysiol.00006.2008
Dandona P, Weinstock R, Thusu K, Abdel-Rahman E, Aljada A, Wadden T. 1998. Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. Journal of Clinical Endocrinology & Metabolism 83, 2907–2910. http://dx.doi.org/10.1210/jc.83.8.2907
Eizadi M, Khorshidi D, Seyedhoseini MA, Dooaly H. 2011. Increased interleukin-6 is associated with low cardiorespiratory fitness in healthy people. Journal of Biodiversity and Environmental Sciences 1(4), 48-54.
Gielen S, Adams V, obius-Winkler SM. 2003. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure,” Journal of the American College of Cardiology 42(5), 861–868. http://dx.doi.org/10.1016/S0735-1097(03)00848-9
Greiwe JS, Cheng B, Rubin DC, Yarasheski KE, Semenkovich CF. 2001. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. Federation of American Societies for Experimental Biology 15, 475–482. http://dx.doi.org/10.1096/fj.00-0274com
Halle M, Korsten-Reck U, Wolfarth B. 2004. Low-grade systemic inflammation in overweight children: impact of physical fitness. Exercise Immunology Review 10, 66–74.
Hamer M. 2007. The relative influences of fitness and fatness on inflammatory factors. Preventive medicine 44, 3–11. http://dx.doi.org/10.1016/j.ypmed.2006.09.005
Hotamisligil GS, Bdavari A, Murray D, Spiegelman BM. 1994. Reduced tyrosine kinase activity of the insulin receptor in Obesity diabetes. Central role of TNF alpha. Journal of Clinical Investigation 94, 1543-1549. http://dx.doi.org/10.1172/JCI117495
Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444, 860-7. http://dx.doi.org/10.1038/nature05485
Kelly AS, Wetzsteon RJ, Kaiser DR. 2004. Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise. Journal of Pediatrics 145, 731–736. http://dx.doi.org/10.1016/j.jpeds.2004.08.004
Kopp HP, Krzyzanowska K, Mohlig M, Spranger J, Pfeiffer AF, Schernthaner G. 2005. Effects of marked weight loss on plasma levels of adiponectin, markers of chronic subclinical inflammation and insulin resistance in morbidly obese women. International Journal of Obesity 29, 766–771. http://dx.doi.org/10.1038/sj.ijo.0802983
Larsen AI, Aukrust P, Aarsland T, Dickstein K. 2001. Effect of aerobic exercise training on plasma levels of tumor necrosis factor alpha in patients with heart failure. American Journal of Cardiology 88, 805–808. http://dx.doi.org/10.1016/S0002-9149(01)01859-8
LeMaitre JP, Harris S, Fox KAA, Denvir M. 2004. Change in circulating cytokines after 2 forms of exercise training in chronic stable heart failure, American Heart Journal 147(1), 100–105. http://dx.doi.org/10.1016/j.ahj.2003.07.001
Mingrone G, Rosa G, Di RP, Manco M, Capristo E, Castagneto M, Vettor R, Gasbarrini G, Greco AV. 2002. Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-alpha reduction and GLUT4 expression enhancement. International journal of obesity and related metabolic disorders 26, 1165–1172. http://dx.doi.org/10.1038/sj.ijo.0802053
Miyazaki Y. 2003. TNFalpha and Insulin Resistance in Type 2Diabetes Mellitus. International Journal of Obesity 27, 88-94. http://dx.doi.org/10.1038/sj.ijo.0802187
Moschen AR, Molnar C, Geiger S, Graziadei I, Ebenbichler CF, Weiss H. 2010. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor {alpha} expression. Gut 59(9),1259-64. http://dx.doi.org/10.1136/gut.2010.214577
Nadia A. Abdel M, Kholoud S. 2012. Level of Pro-and Anti-inflammatory Cytokines In Non-Alcoholic Fatty Liver Disease in Egyptian Patients. International Journal of Research in Management & Technology 2(2), 233-242.
Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, Palla S. 2004. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. American Journal of Clinical Nutrition 79, 544–551.
Parsa M, Najafi SN, Jonaidi N, Mohraz M, Ghavamzadeh A. 2007. Diagnostic relevance of interleukin-6 and tumor necrosis factor alpha in discriminating high risk and low risk groups in febrile patients with neutropenia. Journal of Biological Science 7(2), 338-342. http://dx.doi.org/10.3923/jbs.2007.338.342
Platat C, Wagner A, Klumpp T. 2006. Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents. Diabetologia 49, 2078–2085. http://dx.doi.org/10.1007/s00125-006-0320-6
Rajarajesyari D, Ramalingam K, Krisnamma M, Sharmil Krishna T. 2011. Association of TNF-α a with obesity in type 2 diabetes mellitus. International Journal of Pharma and Bio Sciences 2(2), 352-7.
Ruiz JR, Ortega FB, Warnberg J. 2007. Associations of low-grade inflammation with physical activity, fitness and fatness in prepubertal children; the European Youth Heartstudy. International Journal of Obesity (Lond) 31, 1545–1551. http://dx.doi.org/10.1038/sj.ijo.0803693
Simona Gwozdziewiczova, Radka Lichnovska, Rabha Ben Yahia, Rudolf Chulp, Jiri Hrebicek. 2005. TNF alpha in the development of Insulin Resistance and other disorders in Metabolic Syndrome. Biomedical Journal 149(1), 109-117.
Tilg H, Moschen AR. 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology 6, 772-83. http://dx.doi.org/10.1038/nri1937
Tzanavari T, Giannogonosa P, Karalis KP. 2010. TNF alpha and obesity. Current directions in autoimmunity 11, 145-156. http://dx.doi.org/10.1159/000289203
White LJ, Castellano V, McCoy SC. 2006. Cytokine responses to resistance training in people with multiple sclerosis. Journal of Sports Sciences 24, 911–914. http://dx.doi.org/10.1080/02640410500357036
Williams MJ, Milne BJ, Hancox RJ. 2005. C-reactive protein and cardiorespiratory fitness in young adults. European Journal of Cardiovascular Prevention & Rehabilitation 12, 216–220. http://dx.doi.org/10.1097/00149831-200506000-00005
Xu D, Wang B, Hou Y, Hui H, Meng S, Liu Y. 2002. The effects of exercise training on plasma tumor necrosis factor-alpha, blood leucocyte and its components in congestive heart failure patients, Zhonghua Nei Ke Za Zhi 41(4), 237–240.
Zahorska Markiewicz B, Janowska J, Olszanecka Glinianowicz M, Zurakowski A. 2000. Serum concentration of TNF alpha and soluble TNF alpha receptors in Obesity. International journal of obesity and related metabolic disorders 24, 1392-1395.
Mona Sarhadi, Ali Khorjahani, Zabihallah Naghiloo, Ghanbari Shahpour (2014), Anti-inflammatory effects of exercise training on Tumor necrosis factor-alpha in obese women; JBES, V4, N2, February, P141-147
https://innspub.net/anti-inflammatory-effects-of-exercise-training-on-tumor-necrosis-factor-alpha-in-obese-women/
Copyright © 2014
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0