Anti-inflammatory, immunomodulatory and antimicrobial effects of newlectins extracted from roots of Algerian plants: Urtica dioica.L., Anacyclu spyrethrum L., Brassica napus L. and Calycoto mespinosa L.

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Research Paper 01/05/2022
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Anti-inflammatory, immunomodulatory and antimicrobial effects of newlectins extracted from roots of Algerian plants: Urtica dioica.L., Anacyclu spyrethrum L., Brassica napus L. and Calycoto mespinosa L.

Ahlem Bahi, Youcef Necib, Imen Torche, Sana Boufker
Int. J. Biosci.20( 5), 53-66, May 2022.
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The lectins are present inthe root of plants Urtica dioica.L., Anacyclus pyrethrum L., Brassica napus L., and Calycotome spinosa L.were extracted by soluble proteins (crude extract) in phosphate buffer (0.1M, pH 7.2). The lectin of the plants agglutinated, specifically rabbit erythrocytes and the lectin was extracted from Anacyclus pyrethrum L.pecific for blood B human group. Extracted lectin ofplantsshowed thethermostability is more than 100°C. However, the lectin ofall plantswere stable in the differentes pH ranging and were inhibited by the sugars glucose, galactose and mannose for lectin extracted from plant Brassica napus. L and N-acetyl-glucosamine for lectin extracted from Urtica dioica.L. Immunomodulatory activities of extracted lectins fromUrtica dioica.L and Brassica napus. L were evaluated on phagocytic activity by carbon clearance test.. The present study thus reveals that extracted lectins fromUrtica dioica.L and Brassica napus. L holds promise as an immunomodulatory agent, which act by stimulating dose-dependent phagocytic function. Furthermore, extracted lectins of Urtica dioica.L, Anacyclus pyrethrum. L, Brassica napus. L and Calycotomespinosa. L showed highly antimicrobial and anti-inflammatory activities.


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