Int. J. Biosci.19(2), 180-195, August 2021
Inflammation process is the response of an immune system which could be occur by a number of factors related to microorganisms and may lead to risk of many chronic diseases. Inflammatory response could be chronic or acute. Anti-inflammatory nutrients is a part of our daily nutrition having anti-inflammatory properties of activating our defense system against many illnesses through some mechanisms and cycles which help to boost up our immune system and can prevent progression of inflammatory diseases. Anti-inflammatory foods like fruits, vegetables and grains provide many active ingredients that help to induce anti-inflammatory and anti-oxidative responses like resveratrol, eugenol, curcumin, lycopene and many other byproducts that help strengthen our immunity. The main purpose of this article to provide information regarding nutrients having inflammatory properties and responses. According to many researches, nutrient compounds having anti-Inflammatory response play a vital role in reducing inflammation. Anti-inflammatory ingredients are introduced as anti-inflammatory medications into the pharmaceutical industries to treat diseases and reduce risk of chronic diseases in high risk groups.
Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. 2004. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research 24(5A), 2783-2840.
Alarcon De La Lastra C, Villegas I. 2005. Resveratrol as an anti‐inflammatory and anti‐aging agent: Mechanisms and clinical implications. Molecular Nutrition & Food Research 49(5), 405-430.
Alvarez-Suarez JM, Carrillo-Perdomo E, Aller A, Giampieri F, Gasparrini M, González-Pérez L, Battino M. 2017. Anti-inflammatory effect of Capuli cherry against LPS-induced cytotoxic damage in RAW 264.7 macrophages. Food and Chemical Toxicology 102, 46-52.
Basnet P, Skalko-Basnet N. 2011. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 16(6), 4567-4598.
Bastianetto S, Ménard C, Quirion R. 2015. Neuroprotective action of resveratrol. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852(6), 1195-1201.
Bereswill S, Muñoz M, Fischer A, Plickert R, Haag LM, Otto B, Heimesaat MM. 2010. Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PloS one 5(12), e15099.
Berman AY, Motechin RA, Wiesenfeld MY, Holz MK. 2017. The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precision Oncology 1(1), 1-9.
Boukhatem MN, Ferhat MA, Kameli A, Saidi F, Kebir HT. 2014. Lemon grass (Cymbopogon citratus) essential oil as a potent anti-inflammatory and antifungal drugs. Libyan Journal of Medicine 9(1).
Burns J, Yokota T, Ashihara H, Lean ME, Crozier A. 2002. Plant foods and herbal sources of resveratrol. Journal of Agricultural and Food Chemistry 50(11), 3337-3340.
Calder PC. 2015. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance Molecular and cell biology of lipids.
Cárdenas C, Quesada AR, Medina MA. 2011. Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. PloS one 6(8), e23407.
Chatterjee D, Bhattacharjee P. 2015. Use of eugenol-lean clove extract as a flavoring agent and natural antioxidant in mayonnaise: product characterization and storage study. Journal of food Science and Technology 52(8), 4945-4954.
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Zhao L. 2018. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9(6), 7204.
Counet C, Callemien D, Collin S. 2006. Chocolate and cocoa: New sources of trans-resveratrol and trans-piceid. Food Chemistry 98(4), 649-657.
Csiszar A. 2011. Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease. Annals of the New York Academy of Sciences 1215, 117.
D’Eliseo D, Velotti F. 2016. Omega-3 fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy. Journal of Clinical Medicine 5(2), 15.
Da Silva-Buzanello RA, Ferro AC, Bona E, Cardozo-Filho L, de Araújo PHH, Leimann FV, Gonçalves OH. 2015. Validation of an Ultraviolet–visible (UV–Vis) technique for the quantitative determination of curcumin in poly (l-lactic acid) nanoparticles. Food Chemistry 172, 99-104.
Darvesh SA, Aggarwal BB, Bishayee A. 2012. Curcumin and liver cancer: a review. Current Pharmaceutical Biotechnology 13(1), 218-228.
Das S, Das DK. 2007. Anti-inflammatory responses of resveratrol. Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets-Inflammation & Allergy) 6(3), 168-173.
Das UN. 2019. Molecular Mechanisms of Action of Curcumin and Its Relevance to Some Clinical Conditions. In Curcumin for Neurological and Psychiatric Disorders (pp. 325-332). Academic Press.
Deacon G, Kettle C, Hayes D, Dennis C, Tucci J. 2017. Omega 3 polyunsaturated fatty acids and the treatment of depression. Critical reviews in Food Science and Nutrition 57(1), 212-223.
Eilander A, Hundscheid DC, Osendarp SJ, Transler C, Zock PL. 2007. Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies. Prostaglandins, Leukotrienes and Essential Fatty Acids 76(4), 189-203.
Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. 2014. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators of Inflammation- 2014.
Farghali H, Canová NK, Lekić N. 2013. Resveratrol and related compounds as antioxidants with an allosteric mechanism of action in epigenetic drug targets. Physiological Research 62(1).
Feldman E. 2019. Do Omega-3 Polyunsaturated Fatty Acids Play a Role in the Treatment of Anxiety?. Integrative Medicine Alert 22(3).
Firozi PF, Aboobaker VS, Bhattacharya RK. 1996. Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1. Chemico-biological Interactions 100(1), 41-51.
Fougère B, Boulanger E, Nourhashémi F, Guyonnet S, Cesari M. 2017. Retracted: Chronic Inflammation: Accelerator of Biological Aging. The Journals of Gerontology: Series A, 72(9), 1218-1225.
Ghosh S, Banerjee S, Sil PC. 2015. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food and Chemical Toxicology 83, 111-124.
Han X, Parker TL. 2017. Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts. Pharmaceutical Biology 55(1), 1619-1622.
Haß U, Herpich C, Norman K. Anti-inflammatory diets and fatigue. Nutrients. 2019 Oct 11(10), 2315.
Hassan FU, Rehman MSU, Khan MS, Ali MA, Javed A, Nawaz A, Yang C. 2019. Curcumin as an alternative epigenetic modulator: Mechanism of action and potential effects. Frontiers in Genetics 10, 514.
He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. 2015. Curcumin, inflammation, and chronic diseases: how are they linked. Molecules 20(5), 9183-9213.
Huang X, Liu Y, Lu Y, Ma C. 2015. Anti-inflammatory effects of eugenol on lipopoly saccharide-induced inflammatory reaction in acute lung injury via regulating inflammation and redox status. International Immune-pharmacology 26(1), 265-271.
Jeena K, Liju VB, Umadevi NP, Kuttan R. 2014. Antioxidant, anti-inflammatory and antinociceptive properties of black pepper essential oil (Piper nigrum Linn). Journal of Essential Oil Bearing Plants 17(1), 1-12.
Kalinski P. 2012. Regulation of immune responses by prostaglandin E2. The Journal of Immunology 188(1), 21-28
Kamatou GP, Vermaak I, Viljoen AM. 2012. Eugenol from the remote Maluku Islands to the international market place: a review of a remarkable and versatile molecule. Molecules 17(6), 6953-6981
Khatami M. 2017. Immune surveillance in health and diseases of aging: definitions of acute and chronic inflammation [Yin and Yang]. In Inflammation, aging and cancer (pp. 37-89). Springer, Cham.
Kim SS, Oh OJ, Min HY, Park EJ, Kim Y, Park HJ, Lee SK. 2003. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264. 7 cells. Life Sciences 73(3), 337-348.
Koh T, Murakami Y, Tanaka S, Machino M, Sakagami H. 2013. Re-evaluation of anti-inflammatory potential of eugenol in IL-1β-stimulated gingival fibroblast and pulp cells. 27(2), 269-273.
Lançon A, Frazzi R, Latruffe N. 2016. Anti-oxidant, anti-inflammatory and anti-angiogenic properties of resveratrol in ocular diseases. Molecules 21(3), 304.
Lee KG, Shibamoto T. 2000. Antioxidant properties of aroma compounds isolated from soybeans and mung beans. Journal of Agricultural and Food Chemistry 48(9), 4290-4293.
Lim EWT, Leach ST, Lemberg DA, Day AS. 2016. A Brief Overview of Nutrient Anti-Inflammatory Molecules.
Liu Y, Kakani R, Nair MG. 2012. Compounds in functional food fenugreek spice exhibit anti-inflammatory and antioxidant activities. Food Chemistry 131, 1187-1192.
Logan AC. 2003. Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. Alternative Medicine Review 8(4), 410-425.
Ma X, Yu H. 2006. Cancer issue: global burden of cancer. The Yale Journal of Biology and Medicine 79(3-4), 85.
Magalhães CB, Riva DR, DePaula LJ, Brando-Lima A, Koatz VLG, Leal-Cardoso JH, Faffe DS. 2010. In vivo anti-inflammatory action of eugenol on lipopolysaccharide-induced lung injury. Journal of Applied Physiology 108(4), 845-851.
Mandal A, Bhatia D, Bishayee A. 2017. Anti-inflammatory mechanism involved in pomegranate-mediated prevention of breast cancer: the role of NF-κB and Nrf2 signaling pathways. Nutrients 9(5), 436.
Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. 2013. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. International Journal of Preventive Medicine 4(Suppl 1), S36.
Mason RP. 2019. New insights into mechanisms of action for omega-3 fatty acids in atherothrombotic cardiovascular disease. Current Atherosclerosis Reports 21(1), 2.
Mason RP, Jacob RF, Shrivastava S, Sherratt SC, Chattopadhyay A. 2016. Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes. Biochimica et Biophysica Acta (BBA)-Biomembranes 1858(12), 3131-3140.
Mozaffarian D, Ascherio A, Hu FB, Stampfer MJ, Willett WC, Siscovick DS, Rimm EB. 2005. Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation 111(2), 157-164.
Naderali EK. 2009. Obesity and cardiovascular dysfunction: A role for resveratrol. Obesity research & clinical practice 3(1), 45-52.
O’Mahoney LL, Matu J, Price OJ, Birch KM, Ajjan RA, Farrar D, Campbell MD. 2018. Omega-3 polyunsaturated fatty acids favourably modulate cardiometabolic biomarkers in type 2 diabetes: A meta-analysis and meta-regression of randomized controlled trials. Cardiovascular Diabetology 17(1), 98.
Oscarsson J, Hurt-Camejo E. 2017. Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review. Lipids in Health and Disease 16(1), 149.
Pangeni R, Sahni JK, Ali J, Sharma S, Baboota S. 2014. Resveratrol: review on therapeutic potential and recent advances in drug delivery. Expert Opinion on Drug Delivery 11(8), 1285-1298.
Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, Lo Muzio L. 2015. Biological and therapeutic activities, and anticancer properties of curcumin. Experimental and Therapeutic Medicine 10(5), 1615-1623.
Plaza-Díaz J, Ruiz-Ojeda FJ, Vilchez-Padial LM, Gil A. 2017. Evidence of the anti-inflammatory effects of probiotics and synbiotics in intestinal chronic diseases. Nutrients 9(6), 555.
Prakash P, Gupta N. 2005. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian Journal of Physiology and Pharmacology 49(2), 125.
Ramadan G, Al-Kahtani MA, El-Sayed WM. 2011. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation 34(4), 291-301.
Rapaport MH, Nierenberg AA, Schettler PJ, Kinkead B, Cardoos A, Walker R, Mischoulon D. 2016. Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: A proof-of-concept study. Molecular psychiatry 21(1), 71-79.
Roberto M, Fazel S, Mohammad S, Rafaela F. 2017. Omega-3 polyunsaturated fatty acids and mitochondria, back to the future. Trends in Food Science & Technology. News & Views 1(2), 15-21.
Saini RK, Keum YS. 2018. Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance- A review. Life sciences 203, 255-267.
Sanders TH, McMichael RW, Hendrix KW. 2000. Occurrence of resveratrol in edible peanuts. Journal of Agricultural and Food Chemistry 48(4), 1243-1246.
Sari TP, Mann B, Kumar R, Singh RRB, Sharma R, Bhardwaj M, Athira S. 2015. Preparation and characterization of nanoemulsion encapsulating curcumin. Food Hydrocolloids 43, 540-546.
Sen P. 1993. Therapeutic potentials of Tulsi: from experience to facts. Drugs News & Views 1(2), 15-21.
Serafini M, Peluso I. 2016. Functional foods for health: the interrelated antioxidant and anti-inflammatory role of fruits, vegetables, herbs, spices and cocoa in humans. Current Pharmaceutical Design 22(44), 6701-6715.
Shlar I, Droby S, Rodov V. 2017. Modes of antibacterial action of curcumin under dark and light conditions: A toxicoproteomics approach. Journal of Proteomics 160, 8-20.
Siviero A, Gallo E, Maggini V, Gori L, Mugelli A, Firenzuoli F, Vannacci A. 2015. Curcumin, a golden spice with a low bioavailability. Journal of Herbal Medicine 5(2), 57-70.
Talhouk RS, Karam C, Fostok S, El-Jouni W, Barbour EK. Anti-inflammatory bioactivities in plant extracts. Journal of Medicinal Food. 2007 Mar 1 10(1), 1-0.
Teow SY, Liew K, Ali SA, Khoo ASB, Peh SC. 2016. Antibacterial action of curcumin against Staphylococcus aureus: A brief review. Journal of Tropical Medicine 2016.
Trebatická J, Dukát A, Ďuračková Z, Muchová J. 2017. Cardiovascular diseases, depression disorders and potential effects of omega-3 fatty acids. Physiological Research 66(3).
Watson RR, Preedy VR (Eds.). (2019). Bioactive food as dietary interventions for diabetes. Academic Press.
Xu XY, Meng X, Li S, Gan RY, Li Y, Li HB. 2018. Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives. Nutrients 10(10), 1553.
Yadav MK, Chae SW, Im GJ, Chung JW, Song JJ. 2015. Eugenol: A phyto-compound effective against methicillin-resistant and methicillin-sensitive Staphylococcus aureus clinical strain biofilms. PLoS One 10(3), e0119564
Yahfoufi N, Alsadi N, Jambi M, Matar C. 2018. The immune-modulatory and anti-inflammatory role of polyphenols. Nutrients 10(11), 1618.
Yu WG, Xu G, Ren GJ, Xu X, Yuan HQ, Qi XL, Tian KL. 2011. Preventive action of curcumin in experimental acute pancreatitis in mouse. The Indian Journal of Medical Research 134(5), 717.
Yu J, Bi X, Yu B, Chen D. 2016. Isoflavones: anti-inflammatory benefit and possible caveats. Nutrients 8(6), 361.
Zhang F, Liu J, Shi JS. 2010. Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation. European Journal of Pharmacology 636(1-3), 1-7.
Zhang H, Chen X, He JJ. 2009. Pharmacological action of clove oil and its application in oral care products. Oral Care Industry 19, 23-24.
Zhang P, Zhang E, Xiao M, Chen C, Xu W. 2013. Study of anti-inflammatory activities of α-d-glucosylated eugenol. Archives of Pharmacal Research 36(1), 109-115.
Zimmer AR, Leonardi B, Miron D, Schapoval E, de Oliveira JR, Gosmann G. 2012. Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach. Journal of Ethnopharmacology 139(1), 228-233.