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Anti-inflammatory property of short-term regular exercise training in the absence of weight loss

Research Paper | March 1, 2013

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Shafabakhsh Sayyed Rafi, Kaboli Mohamadzaman, Parsian Heshmatolah

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Int. J. Biosci.3( 3), 176-181, March 2013

DOI: http://dx.doi.org/10.12692/ijb/3.3.176-181


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To evaluate the effect of short-term aerobic training on serum C reactive protein as a proinflammatory cytokine, thirty four sedentary healthy obese or overweight women matched for age (38.06 ± 4.83 years of old) and BMI (26 ≤ BMI ≤ 35) participated in this study by accidentally samples and were randomly divided into control and exercise group. For this purpose, fasting serum C reactive protein (CRP) and all anthropometrical markers were measured before and after a aerobic exercise program (6 weeks/3 times weekly) in two groups. Student’s paired ‘t’ test was applied to compare the pre and post training values. Aerobic training led to decrease in body weight and body mass index but insignificantly. Serum CRP decreased significantly after exercise program when compared to pre-training in exercise group. All variables remained without change in control subjects. Based on these data, we can say that aerobic training for short-time improves serum CRP independent of each change in anthropometrical markers in obese or overweight women.


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Anti-inflammatory property of short-term regular exercise training in the absence of weight loss

Anker SD, Von H. 2004. Inflammatory mediators in chronic heart failure: an overview. Heart 90, 464-70. http://dx.doi.org/10.1136/hrt.2002.007005

Bermudez EA, Rifai N, Buring J. 2002. Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women. Arterioscler Thrombosis Vascular Biology 22, 1668- 73. http://dx.doi.org/10.1161/01.ATV.0000029781.3132.66

Campbell KL, Campbell PT, Urich CM, Wener M, Alfano CM, Foster-Schubert K, Rudolph RE, Potter JD. 2008. No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiology, Biomarkers & Prevention 17, 1714–8. http://dx.doi.org/10.1158/1055-9965.EPI-08-0088

Eizadia M, Kohandel M, Kasbparast JRM, Sars hin A. 2011. Adipocytes-secreted hormone leptin, lipid profile and aerobic exercise program. South Asian Journal of Experimental Biology 1(6), 292-297.

Eizadib M, Khorshidi D, Dooaly H, Samarikhalaj H. 2011. Adiponectin and insulin resistance responses to aerobic training in males with abdominal obesity. Journal of Biodiversity and Environmental Sciences 1(6), 228-235.

Ekmekci H, Ekmekci OB. 2006. The role of adiponectin in atherosclerosis and thrombosis. Clinical and Applied Thrombosis/Hemostasis 12,163–8.

Festa A, D’Agostino Jr R, Howard G. 2000. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102, 42- 7.

Havel PJ. 2002. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Current Opinion in Lipidology 13, 51- 9.

Hong J, Gu W, Zhang Y, Yang Y, Shen C, Xu M, Li X, Wang W, Ning G. 2007. The interplay of insulin resistance and beta-cell dysfunction involves the development of type 2 diabetes in Chinese obeses. Endocrine 31, 93–99. http://dx.doi.org/10.1007/s12020-007-0002-2

Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444, 86-7.

Hu G, Tuomilehto J, Silventoinen K, Barengo NC, Peltonen M, Jousilahti P. 2005. The effects of physical activity and body mass index on cardiovascular, cancer and all-cause mortality among 47 212 middle-aged Finnish men and women. International journal of obesity and related metabolic disorders 8, 894-902.

Kim SK, Jung I, Kim JH. 2008. Exercise reduces C-reactive protein and improves physical function in automotive workers with low back pain. Journal of Occupational Rehabilitation 18, 218–22. http://dx.doi.org/10.1007/s10926-007-9120-1

Marcell TJ, McAuley KA, Traustadóttir T, Reaven PD. 2005. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 54(4), 533-41. http://dx.doi.org/10.1016/j.metabol.2004.11.008.

Nicklas BJ, You T, Pahor M. 2005. Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. Canadian Medical Association Journal 172, 1199–209. http://dx.doi.org/10.1503/cmaj.1040769

Panagiotakos DB, Pitsavos C, Chrysohoou C, Skoumas E, Stefanadis C. 2008. Five-year incidence of cardiovascular disease and its predictors in Greece: the ATTICA study. Vascular Medicine 13, 113–21.

Pue CA, Mortensen RF, March CB. 1996. Acute phase levels of C-reactive protein enhance IL-1 beta and IL-1ra production by human blood monocytes but inhibit IL-1 beta and IL-1ra production by alveolar macrophages. Journal of Immunolojy 156, 1594- 600.

Richa GT, Anterpreet A, Rachna B. 2010. Effect of Physical Training on Pulmonary Function Tests in Border Security Force Trainees of India. Journal of Life Sciences, 2(1), 11-15.

Ridker PM, Rifai N, Rose L. 2002. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. New England Journal of Medicine 347, 1557 -65. http://dx.doi.org/10.1056/NEJMoa021993

Schultz DR, Arnold PI. 1990. Properties of four acute phase proteins: C-reactive protein, serum amyloid A protein, a1-acid lycoprotein and fibrinogen. Seminars in Arthritis and Rheumatism 20, 129–47.

Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, et al. 2006. High sensitivity C-reactive protein in asthma. European Respiratory Journal 27(5), 908- 12. http://dx.doi.org/10.1183/09031936.06.00114405

Tilg H, Moschen AR. 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology 6, 772-83. http://dx.doi.org/doi:10.1038/nri1937

Utzschneider K, Prigeon R, Carr D, Hull R, Tong J, Shofer J, Retzlaff B, Knopp R, Kahn S. 2006. Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses. Diabetes Care 29, 356–362.

Varady KA, Tussing L, Bhutani S, Braunschweig CL. 2009. Degree of weight loss required to improve adipokine concentrations and decrease fat cell size in severely obese women. Metabolism. 58(8), 1096-101. http://dx.doi.org/10.1016.j.metabol.2009.04.010

Yudkin JS, Kumari M, Humphries SE. 2000. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148, 209- 14.

Zwaka TP, Hombach V, Torzewski J. 2001. C-Reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis. Circulation 103, 1194- 7.