Antibacterial and mycelial growth inhibition of some acylated derivatives of D-glucopyranoside
Paper Details
Antibacterial and mycelial growth inhibition of some acylated derivatives of D-glucopyranoside
Abstract
Methyl 4,6-O-benzylidene-α-D-glucopyranoside acylated derivatives (2-12) were employed as test chemicals for in vitro antimicrobial evaluation against four Gram-positive and six Gram-negative human pathogenic bacteria andthree phytopathogenic fungi. It was revealed that a good number of tested chemicals exhibited moderate to good antimicrobial activities. It was found that these tested compounds were more effective against the phytopathogenic fungi than those of the bacterial strains. However, Methyl 4,6-O-benzylidene-2-O-(4-t-butylbenzoyl)-3-O-lauroyl-α-D-glucopyranoside (6) (19.5 mm) exhibited better antibacterial activity than the standard antibiotic, ampicillin (18 mm). Also, it has been observed that the mycelial growth inhibition of methyl 4,6-O-benzylidene-2-O-(4-t-butylbenzoyl)-3-O-(2,6-dichlorobenzoyl)-α-D-glucopyranoside (11) showed the highest inhibition (53.84%) against the Fusarim equiseti than that of standard antibiotic, nystatin (44.70%).
Gornik O, Dumic J, Flogel M, Lauc G. 2006. Glycoscience – a new frontier in rational drug design. Acta Pharmaceutica 56, 19-30.
Singh H, Shukla KN, Dwivedi R, Dhar L, Yadav S. 1990. Cycloaddition of 4-amino-3-mercapto-1,2,4-triazole to heterocumulenes and antifungal activity of the resulting 1,2,4-triazole[3,4-C]-1,2-dithia-4,5-diazines. Journal of Agricultural and Food Chemistry 38, 1483-1486.
Andry C, Wylde R, Laffite C, Privat G. Winternitz I. 1982. Structures of verbascoside and orobanchoside caffeic acid sugar esters from Orobanche rapumgenistae. Phytochemistry 21, 1123-1127.
Abul KMSK, Sarkar MAK, Bhuiyan MMR, Rahman MS, Banu B. 2007. Antimicrobial screening of some decanoyl derivatives of methyl 4,6-O-cyclohexylidene-α-D-glucopyranoside. The Chittagong University Journal of Biological Sciences 2, 81-92.
Abul KMSK, Sarkar MAK, Bhuiyan MMR, Rahman MS, Chowdhury ME. 2009. Antimicrobial screening studies of some derivatives of methyl α-D-glucopyranoside. Pakistan Journal of Scientific and Industrial Research 52, 138-142.
Gupta R, Paul S, Gupta AK, Kachroo PL, Bani S. 1997. Synthesis and biological activities of some 2-substituted phenyl-3-(3-alkyl/aryl-5,6-dihydro-s-triazolo[3,4-b][1,3,4]thiazolo-6-yl)-indoles. Indian Journal of Chemistry 36, 707-710.
Abul KMSK, Matin MM, Mridha MAU, Shahed SM. 1998. Antifungal activities of some methyl 6-O-trityl-α-D-mannopyranoside. The Chittagong University Journal of Sciences 22, 40-46.
Abul KMSK, Dutta P, Anwar MN. 2004. Biological evaluation of some acylated derivatives of D-mannose. Pakistan Journal of Biological Sciences 7, 1730-1734.
Abul KMSK, Matin MM, Hossain A, Sattar MA. 2003. Synthesis and antibacterial activities of some rhamnopyranoside derivatives. Journal of the Bangladesh Chemical Society 16, 85-93.
Abul KMSK, Matin MM, Sanaullah AFM, Sattar MA, Rahman MS. 2001. Antimicrobial activities of some lyxoside derivatives. Bangladesh Journal of Microbiology 18, 89-95.
Abul KMSK, Matin MM, Sarkar MAK. 1998. Antimicrobial activities of some selectively acylated uridine derivatives. Chittagong University Studies Part II: Science 22, 37-41.
Bauer AW, Kirby WMM, Sherris JC, Turck M. 1966. Antibiotic susceptibility testing by a standardized single disc method. American Journal of Clinical Pathology 45, 439-476.
Miah MAT, Ahmed HU, Sharma NR, Ali A, Miah SA. 1990. Antifungal activity of some plant extracts. Bangladesh Journal of Botany 19, 05-10.
Grover RK, Moore JD. 1962. Toximetric studies of fungicides against the brown rot organisms Sclerotinia flucticola and S. laxa. Phytopathology. 52, 876-880.
Sarkar M. A. Kawsar, Abul K. M. S. Kabir, Mohammad M. Manik, Mohammed K. Hossain, Mohammad N. Anwar (2012), Antibacterial and mycelial growth inhibition of some acylated derivatives of D-glucopyranoside; IJB, V2, N7, July, P66-73
https://innspub.net/antibacterial-and-mycelial-growth-inhibition-of-some-acylated-derivatives-of-d-glucopyranoside/
Copyright © 2012
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0