Anticancer activity of Cymodocea serrulata against different cell lines
Paper Details
Anticancer activity of Cymodocea serrulata against different cell lines
Abstract
Seagrasses have a long history of being used for a variety of remedial purposes, such as treatment of fever, skin diseases, muscle pains, wounds and stomach problems. Cancer is a debilitating disease resulting from uncontrolled proliferation. One major treatment strategy for cancer is the application of chemotherapeutic drugs which kill cancer cells. In this study the anticancer potentials of plants was investigated against MCF7 cell line (Human breast adenocarcinoma cell line) and SHP-77 (human lung adenocarcinoma epithelial cell line). Cytotoxicity of seagrass extract was determined by MTT assay. The results showed that the methanolic extract of Cymodocea serrulata possessed a moderate amount of anticancer activity and the IC50 value was recorded. The most potent anticancer activity was observed with the methanolic extract of C. serrulata with IC50 values of 52.5 µg/ml and 51.7µg/ml on MCF7 and SHP-77 cells respectively. The ethanolic extract would be studied further for isolation and characterization of active components for lead optimization studies.
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