Anticancer activity of Mentha spicata ethanolic extract against hepatic carcinoma cell lines
Paper Details
Anticancer activity of Mentha spicata ethanolic extract against hepatic carcinoma cell lines
Abstract
Amongst liver cancers, the incidence of hepatocellular carcinoma (HCC) is increasing and has a high mortality rate. Chronic hepatitis B- or hepatitis C-induced cirrhosis is the leading risk factor for HCC. In this study, the anticancer potentials of plants was investigated against HepG2 and SNU-423 cells. Cytotoxicity of extracts was determined by MTT assay. The results showed that the ethanolic extract Mentha spicata possessed a moderate amount of anticancer activity and the IC50 value was recorded. The most potent anticancer activity was observed with the ethanolic extract of Mentha spicata with IC50 values of 55.75µg/ml and 48.50µg/ml on HepG2 and SNU-423 cellsc, respectively. Phytochemical analyses revealed the presence of large amount of phenols and flavonoids in the potent plant extracts which may be suggested to play an important role in their anticancer activities. These results suggest that Mentha spicata is a promising source of useful natural products and offers opportunities to develop novel anticancer drugs.
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V. R. Rakhi, T. S. Dhanaraj, V. Ramamurthy, 2025. Anticancer activity of Mentha spicata ethanolic extract against hepatic carcinoma cell lines. Int. J. Biosci., 26(5), 153-160.
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