Antidiarrhoeal activity of the leaf and fruit extracts of Dillenia indica

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Research Paper 01/12/2011
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Antidiarrhoeal activity of the leaf and fruit extracts of Dillenia indica

M Shafikur Rahman, KM Shams-Ud-Doha, Roksana Rahman
Int. J. Biosci.1( 6), 39-46, December 2011.
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Abstract

Plants are playing an important role in therapy of many diseases. Here we have studied on a plant which is Dillenia indica. In this study, ethanolic extract of the leaf and fruit of Dillenia indica was the experimental sample whereantidiarrhoeal activity was analyzed. The plant parts showed antidiarrhoeal activity which was measured by castor oil induced method and charcoal plug method. In case of castor oil induced method the percent of inhibition of wet feces was measured and significantly decreased the total number of feces produced by the administration of castor oil; in 2nd hour (for leaf extract, 6 for 200 mg/kg dose and 4 at dose of 400 mg/kg and for fruit extract, 5.33 for 200 mg/kg dose and 4 at dose of 400 mg/kg) and 3rd hour (for leaf extract,3 for 200 mg/kg dose and 2 at dose of 400 mg/kg and for fruit extract 4 for 200 mg/kg dose and 3 at dose of 400 mg/kg). In charcoal plug method the activity was measured by distance traveled by the charcoal plug. The result was slightly lower than the control and the standard loperamide showed the maximum antidiarrhoeal effect. The average distance traveled by leaf was 28.67 cm and fruit was 22.67 cm which was lower than the control 41 cm where as the standard loperamide showed the average traveled length of 16 cm.

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