Antifungal activity from aerial part extracts of Leptadeniapyrotechnica (Forsskal.) Decne from the Cholistan Desert, Pakistan
Paper Details
Antifungal activity from aerial part extracts of Leptadeniapyrotechnica (Forsskal.) Decne from the Cholistan Desert, Pakistan
Abstract
This study was carried out with an objective to investigate the antifungal potentials of aerial part of leptadeniapyrotechnica (Forssk) Decne. The aim of the study is to assess the antifungal activity and to determine the zone of inhibition of extracts on fungal strains. The experiment based on ethno-medicinal survey, in the present study, the antifungal activity of methanol, hexane, ethyl acetate and water extracts of aerial part of leptadeniapyrotechnicawas evaluated for potential antifungal activity against pathogenic fungal strains. The antifungal activity was determined in the extracts using disc diffusion method. The antifungal activities of extracts (1.8, 2.9, 6.5, 12.6, 25, 50, and 75μg/ml) of leptadeniapyrotechnicawere tested against five fungal strains Aspergillusflavus, A.fumigatus, A. niger, A. ustusand Candida albicans. Zone of inhibition of extracts were compared with that of standards drug, Flucanazole antifungal activity. The results showed that the remarkable zone of inhibition of the fungal growth was shown against the tested fungi. The antifungal activity of the leptadeniapyrotechnicawas due to the presence of various secondary metabolites. Hence, these plants can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities.
Rao AR, Arshad M, Shafiq M. 1989. Perennial Grass Germplasm of Cholistan Desert and its Phytosociology. Cholistan Institute of Desert Studies, Islamia University, Bahawalpur, Pakistan.P. 160.
Ali I, Chaudhry MS, Farooq U. 2009.Camel rearing in Cholistan Desert of Pakistan. Pakistan Veterinary Journal 29, 85-92.
Akhter R, Arshad M. 2006. Arid rangelands in Cholistan desert (Pakistan). Secheresse 17, 1-8.
Arshad M, Akbar G, Rashid S. 2003.“Wealth of Medicinal Plants of Cholistan Desert, Pakistan”, HamdardMedicus.XLV (4), 25-34.
Ahmad F, Alam MK, Ahmad S. 2011. “The Studies on Medicinal Plants of Cholistan Desert, Pakistan,” Lambert Academic Publishing, Germany, 232.
Satish S, Raveesha KA, Janardhana GR. 1999. Antibacterial activity of plant extracts on phytopathogenic Xanthomonascampestrispathovars. Letter in Applied Microbiology 28, 145–147.
Okigbo RN, Ogbonnaya UO. 2006. Antifungal effects of two tropicalextracts (Ocimumgratissimum and Aframomummelegueta) on post har(Dioscorea spp.) rot. African Journal of Biotechnology 5, 727-731.
Shariff N, Sudarshana MS, Umesha S, Hariprasad P. 2006. Antimicrobial activity of Rauvolfiatetraphylla and Physalis minima leaf and callus extracts. African Journal ofBiotechnology 5, 946-950.
Ergene A, Guler P, Tan S, Mirici S, Hamzaoglu E, Duran A. 2006. Antibacterial and antifungal activity of Heracleumsphondylium subsp. artvinense. African Journal of Biotechnology 5, 1087-1089.
Timothy SY, Wazis CH, Adati RG, Maspalma ID. 2012. Antifungal Activity of Aqueous and Ethanolic Leaf Extracts of Cassia alata Linn. Journal of Applied Pharmaceutical Science 2(7), 182-185. http://dx.doi.org/10.7324/JAPS.2012.2728
Hameed M, Ashraf M, Al-Quriany F, Nawaz T, Ahmadi MSA, Younis A, Naz N. 2011. Medicinal Flora of Cholistan Desert: A Review. Pakistan Journal of Botany. 43, 39-50.
Moustafa AMY, Khodair AI, Saleh MA. 2009. Isolation, Structural Elucidation of Flavonoids Constituents from Leptadeniapyrotechnica and Evaluation of their Toxicity and Antitumor Activity. International Journal of Pharmacognosy 47(6), 539-552. http://dx.doi.org/10.1080/13880200902875065
Ahmadia, F, Sadeghia S, M. Modarresib M, Abiric R, Mikaelic A. 2010. The Chemical Composition, In Vitro Anti-microbial, Antifungal and Antioxidant Activities of the Essential Oil and MethanolicExtracts of Hymenocraterlongiflorus Benth of Iran. Food and Chemical Toxicology 48(5), 1137-1144.
Bauer AW, Kirby WMM, Sheriss JC, Turck M. 1996. Antibiotic Susceptibility Testing by Standardized Single Method.American Journal of Clinical Pathology 45, 493–496.
Shaista Jamil, Saeed Ahmad, Hafiz Muhammad Wariss, Jiang Wei, Tahir Mehmood, Muhammad Afzal, Zafar Iqbal, 2015. Antifungal activity from aerial part extracts of Leptadeniapyrotechnica (Forsskal.) Decne from the Cholistan Desert, Pakistan. Int. J. Biosci., 7(2), 29-35.
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