Antimalarial potential of leaves crude extract of Monotheca buxifolia
Paper Details
Antimalarial potential of leaves crude extract of Monotheca buxifolia
Abstract
The human’s malarial infection is transmitted mainly by Plasmodium vivax and Plasmodium falciparum where the most usual cause of malarial infection is Plasmodium vivax which is about 80% of all malarial cases and 10% of the deaths. So the present study was focused on the effects of methanolic crude extract of Monotheca buxifolia leaves at the concentration 200 μg/ml against Plasmodium falciparum and Plasmodium vivax present in human blood samples. The blood samples (n=100) were collected from both the genders of various ages from six union councils namely, Uster Zai, Dhoda, Khormato, Jerma, Bilitang and Chickar Kot of district Kohat. Out of 100 patients, 4 patients were infected by Plasmodium falciparum (male=3, female=1) and 96 were infected by Plasmodium vivax (male=70, female=26). Maximum inhibition (80%) in the growth of Plasmodium falciparum was exhibited by methanolic fraction at the age groups of 6-15, 16-30 and 31-50 years male and female malarial patients. While, in the case of Plasmodium vivax, maximum percentage inhibition was exhibited by methanolic fraction (male=80%, female=82%) at the age group of 31-50 years. The Resochine (40 µg/ml) was used as positive control exhibited 100% inhibition of malarial parasites. Moreover, distilled water was used as negative control (200µl/ml) caused no effect.
Adewoye EO, Salami AT, Taiwo VO. 2010. Antiplasmodial and toxicological effects of methanolic bark extract of Chrysophyllum albidum in albino mice. Journal of Physiology and Pathology 1(1), 1-9.
Baidya RS. 2011. Simulating impacts of wind farms on local hydrometeorology. Journal of Wind Engineering &Industrial Aerodynamics99, 491-498.
El-Tahir A, Satti GM, Khalid SA. 1999. Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Excellent Journal of Ethnopharmacology64, 227-233.
Escalante A, Ayala F. 1994. Phylogeny of the malarial genus Plasmodium, derived from rRNA gene sequences. Proceedings of National Academy of Sciences USA 91, 11373-7.
Javeria R, Khan UI, Farid S, Kamal S, Aslam N. 2013. Phytochemical screening and evaluation of in-vitro antioxidant potential of Monotheca buxifolia. Journal of Biotechnology and Pharmaceutical Research 4(4), 54-60.
Jurg A, Tomás T, Pividal J. 1991. Antimalarial activity of some plant remedies in use in Marracuene, southern Mozambique. Journal of Ethnopharmacology 33, 79-83.
Kraft C, Jenett-Siems K, Siems K, Jakupovic J, Mavi S, Bienzle U, Eich E. 2003. In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe. Phytotherapy Research 17,123-128. www.dx.doi.org/10.1002/ptr.1066
Krettli AU. 2009. Antimalarial drug discovery: screening of Brazilian medicinal plants and purified compounds. Expert Opinion and Drug Discovery 4, 95-108. www.dx.doi.org/10.1021/bk-1993-0534.ch001
Lorke D. 1983. A new approach to practical acute toxicity testing. Archives of Toxicology 54(4), 275-287. www.dx.doi.org/10.1007/BF01234480
Malik KA. 2011. Flora of Pakistan. P-10. www.efloras.org
Mendis K, Krindery J. 2001. The neglected burden of Plasmodium vivax malaria. American Journal of Tropical & Medical Hygiene 64, 97-106. www.dx.doi.org/10.1.1.512.2298&rep=rep1
Mueller I, Zimmerman PA, Reeder JC. 2007. Plasmodium malariae and Plasmodium ovale: The “bashful” malaria parasites. Trends in Parasitology 23, 278-83.
Olliaro P, Nevill C, Le-Bras J, Ringwald P, Mussano P, Garner P, Brasseur P. 1996. Systematic review of amodiaquine treatment in uncomplicated malaria. Lancet 348, 1196-1201.
Peters W, Portus JH, Robinson BL. 1975. The chemotherapy of rodent malaria. The value of drug resistant strains of Plasmodium berghei in screening for blood schizontocidal activity. Annals of Tropical Medicine and Parasitology 69(2), 155-171.
Prance GT. 2001. Discovering the plant world. Taxon 50, 345-359.
Rashid AS, Khan M. 2009. Ethnobotanical study of the important wild plants of Bahadur Khel track (Tehsil Banda, Daud Shah) in Karak District. Lancet, 19-25.
Riaz U, Hussain Z, Iqbal Z, Hussain J, Khan UF, Khan N, Muhammad Z, Ayaz S, Ahmad S, Rehman UN, Hussain I. 2010. Traditional uses of medicinal plants in Darra Adam Khel, NWFP. Journal of Medicinal Plants Research 4, 1815-1821.
Rodriguez-Morales AJ, Sanchez E, Vargas M, Piccolo C, Colina R, Arria M, Franco-Paredes C. 2006. Pregnancy outcomes associated with Plasmodium vivax malaria in northeastern Venezuela. American Journal of Tropical Medicine and Hygiene74, 755-757.
Shaw D. 1998. Risks or remedies safety aspects of herbal remedies. Journal of the Royal Society of Medicine 91, 294-296.
Sidra F, Khan IU. 2012. Evaluation of antioxidant activity of Monotheca buxifolia by novel and contemporary method. Ravian Forensic Soceity 34, 23-28.
Singh B, Kim SL, Matusop A. 2004. A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet 363, 1017-24.
Trager W, Jensen JB. 1976. Human malaria parasite in continuous culture. Science 193, 673-675.
Burhan Ud Din, Muhammad Afzal, Muhammad Binyamin Khan, Yasir Ihtesham, Muhammad Sadiq, Mohammad Safdar Baloch, Ejaz Ahmad Khan, Muhammad Idrees Khan, Javed Akhtar, Najeeb Ullah (2018), Antimalarial potential of leaves crude extract of Monotheca buxifolia; IJB, V12, N1, January, P27-34
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