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Antimalarial potential of leaves crude extract of Monotheca buxifolia

Research Paper | January 1, 2018

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Burhan Ud Din, Muhammad Afzal, Muhammad Binyamin Khan, Yasir Ihtesham, Muhammad Sadiq, Mohammad Safdar Baloch, Ejaz Ahmad Khan, Muhammad Idrees Khan, Javed Akhtar, Najeeb Ullah

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Int. J. Biosci.12( 1), 27-34, January 2018

DOI: http://dx.doi.org/10.12692/ijb/12.1.27-34


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The human’s malarial infection is transmitted mainly by Plasmodium vivax and Plasmodium falciparum where the most usual cause of malarial infection is Plasmodium vivax which is about 80% of all malarial cases and 10% of the deaths. So the present study was focused on the effects of methanolic crude extract of Monotheca buxifolia leaves at the concentration 200 μg/ml against Plasmodium falciparum and Plasmodium vivax present in human blood samples. The blood samples (n=100) were collected from both the genders of various ages from six union councils namely, Uster Zai, Dhoda, Khormato, Jerma, Bilitang and Chickar Kot of district Kohat. Out of 100 patients, 4 patients were infected by Plasmodium falciparum (male=3, female=1) and 96 were infected by Plasmodium vivax (male=70, female=26). Maximum inhibition (80%) in the growth of Plasmodium falciparum was exhibited by methanolic fraction at the age groups of 6-15, 16-30 and 31-50 years male and female malarial patients. While, in the case of Plasmodium vivax, maximum percentage inhibition was exhibited by methanolic fraction (male=80%, female=82%) at the age group of 31-50 years. The Resochine (40 µg/ml) was used as positive control exhibited 100% inhibition of malarial parasites. Moreover, distilled water was used as negative control (200µl/ml) caused no effect.


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Antimalarial potential of leaves crude extract of Monotheca buxifolia

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