Antimicrobial status of salmonella meningitis in Niger

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Research Paper 01/08/2017
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Antimicrobial status of salmonella meningitis in Niger

A. Ali, O. Sani, A. Moumouni, J. Zanguina, A. Soussou, J. Testa, B. H. Halima
Int. J. Micro. Myco.6( 2), 1-6, August 2017.
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Salmonella meningitis prognosis is poor and the choice of adequate antibiotic therapy is difficult in developing countries where laboratory testing is not accessible. This study aimed to evaluate, the antibiotic susceptibility pattern of salmonella isolated from CSF in meningitis suspected cases and to identify the best drug option. From 2011 to 2015, 6630 CSF collected were sent at CERMES, during laboratory-based surveillance. All turbid and freshly collected CSF from under 5 years patients were subjected to standard bacteriological method for isolation and characterization of meningitis etiologies. A total of 11/6630 Salmonella strains were isolated during this study. This accounted for 0. 2% of the overall CSF analyzed during the 5 years of study. Most of the patients (72.7%) were less than 2 years old. The average age of children was 2.63 years with an extreme of 1 month to 14 years and the sex ratio M/F was 0.83. The antimicrobial susceptibility was performed in vitro, to all the 11 salmonella isolated. The result revealed that 9/11(81.8%) strains were susceptible to ceftriaxone, Amikacin, and Cefoxitin. All the isolates (100%) were sensitive to Imipenem, Nalidixic acid, and Ciprofloxacin. Two strains of salmonella (18.2%) belonged to extended-spectrum beta lactamase (ESBL) producing group.The maximum resistance was observed against Ampicillin (100%), Amoxicillin/clavulanic acid (72.7%) and Gentamicin (27.3%).The Ampicillin MIC value showed 100% resistance to all the strains tested. This study confirmed that ceftriaxone may be used to treat Salmonella meningitis.The isolation of ESBL salmonella strain may be an alarm indicating the worldwide spray of multi-resistant bacterium. However, the limitation in the use of cephalosporin may prevent this increasing resistance.


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