Antimicrobial susceptibility and frequency of methicillin-resistant Staphylococcus aureus (MRSA) isolated from skin infected patients in District Peshawar, KPK, Pakistan

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Research Paper 01/09/2018
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Antimicrobial susceptibility and frequency of methicillin-resistant Staphylococcus aureus (MRSA) isolated from skin infected patients in District Peshawar, KPK, Pakistan

Iqbal Hussain, Saba, Muhammad Junaid, Rahim Dost Khan, Safia Hameed, Nasir Ali, Sifatullah
Int. J. Biosci.13( 3), 223-228, September 2018.
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Staphylococcus aureus (S. aureus) is an important pathogen which causes community associated Methicillin-resistant Staphylococcus aureus in fection (CA-MRSA) and hospital-associated Methicillin-resistant Staphylococcus aureus (HA-MRSA). The objective of the current study was to investigate the frequency and antimicrobial susceptibility of MRSA isolated from clinical settings of Peshawar. Clinical samples including pus and swab were collected, followed by identification of MRSA by microscopic and biochemical based methods. Out of 97 isolates, (27%) were found positive. The frequency of MRSA strains was more in females (57%) than in males (43%). S. aureus was more prevalent in the age group 31-45 years with 42% followed by the age groups 46-60, 16-30 and 1-15 years with 26%, 18%,and 14% respectively. S. aureus showed high resistance to Oxacillin (27%), followed by Clarithromycin (18%), Amikacin and Doxycycline (16%), vancomycin (15%), Cefoxitin (13%), Amoxicillin (12%), linezolid (8%) and Sulzone (7%). The present study highlighted that linezolid and Sulzone were most effective to treat S. aureus infected patients.


Aghazadeh M, Rahbar M, Monnavar MK, Moghadam FS. 2009. Sensitivity pattern of methicillin resistant and methicillin sensitive Staphylococcus aureus isolates, against several antibiotics including tigecycline in Iran: A hospital based study. Pakistan Journal of Medical Sciences 25(3), 443-446.

Bhatt CP, Karki BMS, Baral B, Gautam S, Shah A, Chaudhary A. 2014. Antibiotic susceptibility pattern of staphylococcus aureus and methicillin-resistant staphylococcus aureus in a tertiary care hospital. Journal of Pathology of Nepal 4, 548-551.

Boucher HW, Corey GR. 2008. Epidemiology of methicillin-resistant Staphylococcus aureus. Clinical infectious diseases 46(5), 344-349.

Brown DFJ, Edwards DI, Hawkey PM, Morrison D, Ridgway GL, Towner KJ. 2005. Guidelines for the laboratory diagnosis and susceptibility testing of methicillin-resistant Staphylococcus aureus (MRSA). Journal of Antimicrobial Chemotherapy 56(6), 1000-1018.

Chandrashekhar DK, Chandrakanth C, Sunilkumar B, Gangane R, Basavaraj P, Amaresh, VinodKumar CS. 2012. Prevalence of methicillin resistant Staphylococcus aureus in a tertiary care hospital in Gulbarga, Karnataka. Journal of Pharmaceutical and Biomedical Sciences 19(6), 1-3.

Williams REO. 1963. Healthy carriage of Staphylococcus aureus: its prevalence and importance. Bacteriological reviews 27(1), 56-71.

Ghebremedhin B, Olugbosi MO, Raji AM, Layer F, Bakare RA, König B, Konig W. 2009. Emergence of a community-associated methicillin-resistant Staphylococcus aureus strain with a unique resistance profile in Southwest Nigeria. Journal of Clinical Microbiology 47(9), 2975-2980.

Hartman BJ, Tomasz A. 1986. Expression of methicillin resistance in heterogeneous strains of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 29(1), 85-92.

Khanal LK, Adhikari RP, Guragain A. 2018. Prevalence of Methicillin Resistant Staphylococcus aureus and Antibiotic Susceptibility Pattern in a Tertiary Hospital in Nepal. Journal of Nepal Health Research Council 16(2), 172-174.

Mahmood K, Tahir M, Jameel T, Ziauddin A, Aslam HF. 2010. Incidence of Methicillin-resistant Staphylococcus aureus (MRSA) causing nosocomial infection in a Tertiary Care Hospital. Annals of King Edward Medical University 16(2), 91-96.

Von Eiff C, Becker K, Machka K, Stammer H, Peters G. 2001. Nasal carriage as a source of Staphylococcus aureus bacteremia. New England Journal of Medicine 344(1), 11-16.