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Application of transgenic plants as factories for producing biopharmaceuticals

Hadi Hashemzade, Alireza Zebarjadi, Nasim Akhshi, Kazem Aghaee

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J. Bio. Env. Sci.4(4), 58-74, April 2014


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Antibodies (Ab) are glycoprotein compounds produced by the vertebrate immune-system. They recognize and bind to their aim antigens with high affinity and specificity, which enable them to be used for numerous applications, such as the diagnosis, prevention, resistance to pathogens of plant, and cure of human and animal illness. The importance of antibodies as an in vitro investigation tool has been incorporate in vivo applications in basic researches of proteins and other compounds. Recently, the production of antibodies in plants because many reasons, including low-cost production, ease to storage large-scale production, safety and etc. is proposed. This technology is referring to the plantibody. Plantibody approach is one of the new events in molecular technology field. Plants as a bio-factory can be also used for biopharmaceutical and drugs production. Pharmaceuticals that derived from plants are poised to become the next major commercial development in plant biotechnology. But, however, there are some concerns in this context. In the present article, we try to summarize the recent advances made in the use of transgenic plants as biological factories for the production of drugs, vaccine, and biopharmaceuticals also discuss the plantibodies as a low-cost, efficient method for the production of biological materials with demonstrated utility to the pharmaceutical industry or medical community. In addition, a referring to applications of antibodies produced in plants and has been compared with other expression system.


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Application of transgenic plants as factories for producing biopharmaceuticals

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