J. Bio. Env. Sci.15(5), 106-112, November 2019
This study is aimed at investigating the acute effects of aqueous flower extracts of Tridax procumbens on some haematological and serum lipid parameters at a dose of 100mg/kg/d in Wistar albino rats. Following a 7-day oral administration of the aqueous extract, haematological and serum lipid parameters were evaluated in the 10 Wistar albino rats. The rats weighed 187.7±28.49g and were randomly assigned into two groups (Group A: control and group B: 100mg/kg/d of extract). The evaluation was performed on fully automated analyzers (ERBA diagnostics) immediately after blood sample collection. The 100mg/kg/d of the flower extract caused significant increases in the levels of PCV, HB, MCH, MCHC, MCV and Platelet concentration (41.8±1.64, 13.64±0.41, 30.95±2.57, 32.99±0.67, 92.7±9.51 and 141.2±17.49 respectively) when compared to the controls which received no extract at all. The extract also caused reduction in the serum levels of Total cholesterol, Triglycerides, LDL and VLDL (134.68±5.21, 153.5±5.53, 45.5±7.19, 30.7±1.11 respectively). However, the extract produced a significant elevation in the level of the HDL (58.48±4.11). These changes suggest that flower extract has positive effects on the erythron of wistar rats, hemostatic and lipid lowering/anti-atherogenic properties. In conclusion, the flower extract can be exploited as a potential haematinic agent, haemostatic agent (for wound healing activity) and for its anti-hyperlidaemic/anti-atherogenic properties and thus can be useful for development of therapeutic agents in the prevention or management of diseases associated with haematopoietic and lipid disorders (such as anaemia, thrombocytopenia; obesity, type 2 diabetes mellitus).
Ajeigbe KO, Enitan SS, Omotoso DR, Oladokun OO. 2013. Acute effects of aqueous leaf extracts of Aspiliaafricana C.D Adams on some haematological parameters in rats. Afr J Tradit Complement Altern Med. 10(5), 236-243.
Burton GW, Joyce D, Ingold KU. 1983. Is Vitamin E the only Lipid Soluble Chain Leaving Antioxidant in Human Blood Plasma and Erythrocyte Membrane. Arch Biochem Biophys 222, 228-290.
Garima S, Goyal PK. 2007. Prevention of radiation induced haematological alterations by medicinal plant Rosmarinus officinalis in mice. Afri J Trad Complement Altern Med 4(2), 165-172.
Ikese Z, Kukwa D, Adogal S. Lenka J. 2015. Effect of aqueous leaf extract of Tridax procumbens on blood coagulation. International Journal of Pharmaceutical Sciences and Research 6(8), 3391-3395.
Ikpi DE, Nku CO. 2008. Effect of ethanolic extract of Dennettia tripetala fruit of haematological parameters in albino wistar rats. Niger Journal of Physiol Sci 23(1-2), 13-17.
Jorum OH, Piero NM, Machocho AK. 2016. Haematological Effects of Dichloromethane-Methanolic Leaf Extracts of Carissa edulis (Forssk.) Vahl in Normal Rat Models. J Hematol Thrombo Dis 4, 232.
Kanu KC, Ijeoma SN, Atiata O. 2016. Haematological, Biochemical and Antioxidant changes in Wistar rats exposed to Dichlorvos Based Insecticide Formulation used in South-East Nigeria. Toxics 4(4), 28.
Manjamalia A, Sardar SSR, Guruvayooroppan C, Berlin GVM. 2010. Analysis of phytochemical constituents and antimicrobial activity of some medicinal plants. Global Journal of Biotechnology and Biochemistry 5, 120-128.
Mir AS, Dar MA, Mir S, Ahmad SM, Chitale G. 2017. Analysis of Phytochemistry and Antimicrobial activity of Tridax procumbens Linn. Chem Sci J. 7, 132.
Nwinuka NM, Monanu MO, Nwiloh BI. 2008. Effects of aqueous extract of Mangifera indica L. (mango) stem bark on haematological parameters of normal albino rats. Pak J Nutr 7(5), 663-666.
Odesanmi SO, Lawal RA, Ojokuku SA. 2010. Haematological effects of ethanolic fruit extract of Tetrapleura tetraptera in male Dutch White rabbits. Res J Med Plant 4 (4), 213-217.
Olukunle JO, Abatan MO. 2008. The effects of aqueous leaf extract of Tridax procumbens on the haematological and serum biochemical parameters of wistar albino rats. ASSET Series B. 7(2), 122-127.
Oluyemi KA, Okwuonu UC, Baxter DG, Oyesola TO. 2007. Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats. Int J Morphol 25(3), 609-614.
Otis JP, Sahoo D, Drover VA, Yen C-LE, Carey HV. 2011. Cholesterol and Lipoprotein Dynamics in a Hibernating Mammal. PLoS ONE 6(12), e29111.
Pareek H, Sharma S, Khajja BS, Jain K, Jain GC. 2009. Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn). BMC Complementary and Alternative Medicine 9, 48.
Petchi RR, Vijaya C, Parasuraman S. 2013. Antiarthritic activity of ethanolic extract of Tridax procumbens (Linn.) in Sprague Dawley rats. Pharmacognosy Res 5, 113-117.
Prabhudas S, Patel MH, Shah FP, Jha GN, Raval RM. 2004. Rawal. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J. Cancer 41(1), 25-31.
Thrall MA, Weiser MG. 2002. Haematology. In: Hendrix CM, editor. Laboratory procedures for veterinary technicians. 4th ed. Missouri: Mosby Inc p. 29-74.