Assessing fertility health: A comparative analysis of serum and seminal plasma levels of key biomarkers in fertile and infertile males
Paper Details
Assessing fertility health: A comparative analysis of serum and seminal plasma levels of key biomarkers in fertile and infertile males
Abstract
Although the exact procedure of male sterility is unclear, it is a rapidly developing restorative study. Half of infertile couples worldwide suffer from male reproductive failure. The World Health Organization’s recommendation for standardized sperm testing will improve analytical accuracy by addressing bias in sperm quality assessment. As a result, little is understood about the biochemical elements found in seminal serum and plasma, where they come from, and how they work physiologically in the male reproductive system. Understanding levels of these pivotal biomarkers in serum and seminal plasma may be a valuable insight into the factors that decide male fertility and help aid in the development of targeted diagnostics and treatment strategies. Sperm motility in 26 fertile men and 50 infertile men was studied in this research about serum and semen levels of several components. Extensive investigation on semen parameters and their relationship with blood biochemical parameters revealed that fertile individuals exhibit normative values in semen volume, concentration, motility, and morphology along with normal plasma concentrations of essential elements like calcium, magnesium, zinc, iron, and fructose, indicating favorable nutritional and metabolic conditions for reproductive health. Conversely, deviations from these normative levels in infertile individuals suggest impaired sperm health and function. The complete investigation’s statistically significant data were validated by ANOVA analysis. The results indicated that seminal plasma magnesium remained substantial (P<0.05) and that serum magnesium and calcium levels remained meaningly advanced in the fertile collection related with the infertile cluster. Reasons for male infertility will soon be discovered and addressed thanks to technological breakthroughs and creative thinking; therefore, the introduction of noninvasive and diagnostic biomarkers is essential for the near future of treatments.
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O. Deepa, L. krishnavignesh, Smisha Sridev, A. Mahalakshmipriya, M. Poongothai, V. M. Thomas, 2025. Assessing fertility health: A comparative analysis of serum and seminal plasma levels of key biomarkers in fertile and infertile males. Int. J. Biosci., 27(1), 156-171.
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