Assessment of epidemiological and hematological parameters of dengue virus infection in District Mardan, Khyber Pakhtunkhwa, Pakistan
Paper Details
Assessment of epidemiological and hematological parameters of dengue virus infection in District Mardan, Khyber Pakhtunkhwa, Pakistan
Abstract
Dengue is a tropical disease caused by dengue virus (DENV). It is one of the most significant arthropod-borne viral infection. Dengue fever has been reported from various parts of Pakistan. However, there is still a scarcity of data on the prevalence and incidence of dengue. The aim of the present study was to determine the seroprevalence and hematological changes in dengue virus-positive patients in district Mardan, Khyber Pakhtunkhwa (KP). In the current study, 1000 suspected individuals including 632 male and 368 female samples were collected from different areas of district Mardan. Out of 632 male individual samples, 88 were positive while 46 out of 368 female samples were found positive for dengue infection. The primary and secondary infection was determined through IgM (M=49, F=21) and IgG (M=19, F=15) ICT, and through NS1 (M=20, F=10) ICT strips. Dengue fever also causes hematological changes in infected patients. The complete blood count (CBC) was determined for patients which undergoes hypo-volumatic shock condition. In the infected individuals low TLC, low PLT, high Hb and high HCT values were observed. In the current study, the frequency of infection was higher in male as compared to female. It was also concluded that the dengue infection can be early diagnosed on the basis of described clinical features and with the detection of dengue-specific NS1 antigen along with antibodies such as IgG and IgM.
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