Int. J. Biosci.14(1), 131-139, January 2019
Nickel compounds are classified as carcinogens therefore; there is a need to determine the toxic effects of nickel nanoparticles (Ni-NPs) on organisms’ health. With enhancement in nanotechnology, Ni-NPs are widely used in various fields of daily life. In the present study, Ni-NPs were used to determine their accumulation and toxic effects on histological profiles of spleen of male Sprague Dawley rats. For this purpose twenty five male Sprague Dawley rats weighing (200-250g) were procured from the animal house of Government College University Faisalabad after approval of the ethical committee on animal experimentation of Government College University Faisalabad. Rats were divided into five groups (n=5) as control (without any treatment), saline (treated with 0.9% sodium chloride for the equivalency of shock) and three nano treated groups (i.e., Ni-NPs @ of either 15 or 30 or 45mg/kg b.wt) with five replicates in each group were used to determine the accumulation and toxic effects of Ni-NPs on histological profile of spleen. At the end of the experiment, histological observations showed abnormalities in spleen structure with the formation of macrophage and increased megakaryocytes number, blood vessel damage and alteration in splenic capsule thickness. Fibrosis and necrosis was also observed. All these histological changes along with bio-distribution of Ni in spleen were dose dependent. Histological alterations and accumulation was more adverse at high dose (45mg/kg b.wt) in comparison with low and medium dose as well as control. Therefore, it is concluded that at higher concentration, exposure to Ni NPs is hazardous and should be handled with care.
Abass MA, Selim SA, Selim AO, El-Shal AS, Gouda ZA. 2017. Effect of orally administered Zinc oxide nanoparticles on albino rat thymus and spleen. International Union of Biochemistry and Molecular Biology 69(7), 528-539. https://doi.org/10.1002/iub.1638
Ahamed M, Ali D, Alhadlaq HA, Akhtar MJ. 2013. Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2). Chemosphere 93, 2514-2522. https://doi.org/10.1016/j.chemosphere.2013.09.047
Ahamed M. 2011. Toxic response of nickel nanoparticles in human lung epithelial A549 cells. Toxicology in Vitro 25, 930-6. https://doi.org/10.1016/j.tiv.2011.02.015
Ajdari M, Ghahnavieh MZ. 2014. Histopathology effects of nickel nanoparticles on lungs, liver and spleen tissues in male mice. International nano letters 4, 113. https://doi.org/10.1007/s40089-014-0113-8
Aldahmash BA, El-Nagar DM. 2016. Antioxidant effects of captopril against lead acetate- induced hepatic and splenic tissue toxicity in Swiss albino mice. Saudi journal of biological sciences 23, 667-673. https://doi.org/10.1016/j.sjbs.2016.05.005
Awaad A. 2015. Histopathological and immunological changes induced by magnetite nanoparticles in the spleen, liver and genital tract of mice following intravaginal instillation. The Journal of Basic and Applied Zoology 71, 32–47. https://doi.org/10.1016/j.jobaz.2015.03.003
Cataldi M, Vigliotti C, Mosca T, Cammarota M, Capone D. 2017. Emerging role of the spleen in the pharmacokinetics of monoclonal antibodies, nanoparticles and exosomes. International journal of molecular sciences 18, 1249. https://doi.org/10.3390/ijms18061249
Cempel M, Janicka K. 2002. Distribution of nickel, zinc, and copper in rat organs after oral administration of nickel(II) chloride. Biological Trace Element Research 90, 215-226. https://doi.org/10.1385/BTER:90:1-3:215
Dantey K, Cooper K. 2016. Vascular neoplasms of the spleen. Diagnostic histopathology 22, 12. https://doi.org/10.1016/j.mpdhp.2016.10.001
De-Haar C, Hassing I, Bol M, Bleumink R, Pieters R. 2006. Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clinical and Experimental Allergy 36(11), 1469-1479. https://doi.org/10.1111/j.1365-2222.2006.02586.x
Dumala N, Mangalampalli B, Chinde S, Kumari SI, Mahoob M, Rahman MF, Grover P. 2017. Genotoxicity study of nickel pxide nanoparticles in female wistar rats after acute oral exposure. Mutagenesis 32(4), 417-427. https://doi.org/10.1093/mutage/gex007
Ejaz S, Ejaz A, Sohail A, Ahmed M, Nasir A, Lim CW. 2009. Exposure of smoke solutions from CNG-powered four-stroke auto-rickshaws induces distressed embryonic movements, embryonic hemorrhaging and ectopia cordis. Food and Chemical Toxicology 47, 1442-1452. https://doi.org/10.1016/j.fct.2009.03.026
Gao J, Shi H, Dai Z, Mei X. 2015. Variations of sediment toxicity in a tidal Estuary: a case study of the South Passage, Changjiang (Yangtze) Estuary. Chemosphere 128, 7-13. https://doi.org/10.1016/j.chemosphere.2015.01.007
Glista-Baker EE, Taylor AJ, Sayers BC, Thompson EA, Bonner JC. 2014. Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor TBX21 (T-bet). Particle and Fiber Toxicology 11, 7. https://doi.org/10.1186/1743-8977-11-7
Guo D, Wu C, Hu H, Wang X, Li X, Chen B. 2009. Study on the enhanced cellular uptake effect of daunorubicin on leukemia cells mediated via functionalized nickel nanoparticles. Biomedical Materials 4(2), 025013. (b) https://doi.org/10.1088/1748-6041/4/2/025013
Guo D, Wu C, Li J, Guo A, Li Q, Jiang H, Chen B, Wang X. 2009. Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 cells proliferation. Nanoscale Research Letter 4(12), 1395–1402. (a) https://doi.org/10.1007/s11671-009-9411-x
He MD, Xu SC, Zhang X, Wang Y. 2013. Disturbance of aerobic metabolism accompanies neurobehavioral changes induced by nickel in mice. Neurotoxicology 38, 9-16. https://doi.org/10.1016/j.neuro.2013.05.011
Hillyer JF, Albrecht RM. 2001. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. Journal of Pharmaceutical Sciences 90(12), 1927-1936. https://doi.org/10.1002/jps.1143
Horie M, Fukui H, Nishio K, Endoh S, Kato H, Fujita K, Miyauchi A, Nakamura A, Shichiri M, Ishida N, Kinugasa S, Morimoto Y, Niki E, Yoshida Y, Iwahashi H. 2011. Evaluation of acute oxidative stress induced by NiO nanoparticles in vivo and in vitro. Journal of Occupational Health 53, 64-74. https://doi.org/10.1539/joh.L10121
Hussein AJ. 2015. Histopathological study of lung, kidney, spleen and prostate in adult male rats treated with bisphenol A. Basrah journal of veterinary research 4(2), 74-86.
Jacob SE, Moennich JN, Mckean BA, Zirwas MJ, Taylor JS. 2009. Nickel allergy in the United States: a public health issue in need of “nickel directive”. Journal of the American Academy of Dermatology 60(6), 1067-1069. https://doi.org/10.1016/j.jaad.2008.11.893
Jiang W, Kim BS, Rutka JT, Chan WW. 2008. Nanoparticle-mediated cellular response is size-dependent. Nature Nanotechnology 3(3), 145-50. https://doi.org/10.1038/nnano.2008.30
Karim A, Ahmad N, Ali W. 2016. Histopathological changes in spleen and kidney of silver carp (Hypophthalmicthys molitrix) after acute exposure to Deltamethrin. Biologia 62(1), 139-144.
Kasprzak KS, Sunderman FW, Salnikow K. 2003. Nickel carcinogenesis. Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis 533, 67-97. https://doi.org/10.1016/j.mrfmmm.2003.08.021
Magaye RR, Yue X, Zou B, Shi H, Yu H, Liu K, Lin X, Xu J, Yang C, Wu A, Zhao J. 2014. Acute toxicity of nickel nanoparticles in rats after intravenous injection. International Journal of Nanomedicine 9, 1393-1402. https://doi.org/10.2147/IJN.S56212
Minigalieva IA, Katsnelson BA, Privalova LI, Sutunkova MP, Gurvich VB, Shur VY, Shishkina EV, Valamina IE, Makeyev OH, Panov VG, Varaksin AV, Grigoryeva EV, Meshtcheryakova EY. 2015. Attenuation of combined Nickel (II) oxide and Manganese (II, III) oxide nanoparticles adverse effects with a complex of bioprotectors. International Journal of Molecular Sciences 16, 22555-22583. https://doi.org/10.3390/ijms160922555
Nie S. 2010. Understanding and overcoming major barriers in cancer nanomedicine. Nanomedicine (Lond.) 5, 523–528. https://doi.org/10.2217/nnm.10.23
Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG. Castranova V. 2008. Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction. Particle and Fiber Toxicology 5, 1. https://doi.org/10.1186/1743-8977-5-1
Oberdorster G, Oberdorster E, Oberdorster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspectives 113, 823-839. https://doi.org/10.1289/ehp.7339
Owolabi JO, Ogunsola AO, Fabiyi OS. 2014. Histological assessment of Moringa oleifera ameliorative activities on lead toxicity in the spleen of adult wistar rats. World journal of life science and medical research 3(2), 64.
Phillips JI, Green FY, Davies JC, Murray J. 2010. Pulmonary and systemic toxicity following exposure to nickel nanoparticles. American Journal of Industrial Medicine 53, 763-7.
Prijic S, Sersa G. 2011. Magnetic nanoparticles as targeted delivery systems in oncology. Radiology and Oncology 45(1), 1-16.
Recordati C, Maglie1 MD, Bianchessi S, Argentiere S, Cella C, Mattiello S, Cubadda F, Aureli F, D’Amato M, Raggi A, Lenardi C, Milani P, Scanziani E. 2016. Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects. Particle and Fibre Toxicology 13, 12. https://doi.org/10.1186/s12989-016-0124-x
Thummabancha K, Onparn N, Srisapoome P. 2016. Molecular characterization and expression analyses of cDNAs encoding the thioredoxin interaction protein and selenoprotein P genes and histological changes in Nile tilapis (oreochromis niloticus) in response to silver nanoparticle exposure. Gene 577(2), 161-173. https://doi.org/10.1016/j.gene.2015.11.031
Vemula PK, Anderson RR, Karp JM. 2011. Nanoparticles reduce nickel allergy by capturing metal ions. Nature Nanotechnology 6(5), 291-295. https://doi.org/10.1038/nnano.2011.37
Zhang R, Wang X, Wu C, Chen B, Song M, Li J, Lu G, Zhaou J, Chen C, Dai Y, Gao B, Fu D, Li X, Guan Z. 2006. Synergistic enhancement effect of magnetic nanoparticles on anticancer drug accumulation in cancer cells. Nanotechnology 17(14), 3622-3626. https://doi.org/10.1088/0957-4484/17/14/043
Zhao J, Castranova V. 2011. Toxicology of nanomaterials used in nanomedicine. Journal of Toxicology and Environmental Health- Part B critical review 14(8), 593–632. https://doi.org/10.1080/10937404.2011.615113
Zhao J, Shi X, Castranova V, Ding M. 2009. Occupational toxicology of nickel and nickel compounds. Journal of Environmental Pathology, Toxicology and Oncology 28(3), 177-208. http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.v28.i3.10