Association between serum sirt 1 and advanced glycation end products levels in type 2 diabetic nephropathy patients

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Research Paper 01/05/2017
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Association between serum sirt 1 and advanced glycation end products levels in type 2 diabetic nephropathy patients

Shadia A. Fathy, Doaa M. Ibrahim, Wafik A. Elkhayat, Haidi S. Ahmed
Int. J. Biosci.10( 5), 398-404, May 2017.
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This study aimed to evaluate the association between serum sirtuin1 (Sirt1) and AGEs levels in type 2 diabetes patients with different stages of diabetic kidney disease. Eighty type 2 diabetes patients were divided into three groups: normoalbuminuric group, microalbuminuric group, and macroalbuminuric group, along with 20 age and sex-matched healthy individuals were included in the study. Fasting blood glucose, fasting insulin, Homeostasis model assessment for insulin resistance (HOMA-IR), renal function tests, lipid profile, serum Sirt1 (ELISA) and serum AGEs (ELISA) were evaluated. Comparing to the control group, serum Sirt1 level was significantly lowered in normoalbuminric patients (p< 0.05). While, serum level of AGEs was significantly increased in all diabetic patients (p< 0.001). Serum Sirt1 was negatively correlated with microalbumin in macroalbuminuric patients. Additionally, serum Sirt1 showed a positive correlation with insulin and AGEs levels in total diabetic patients (p< 0.05 and p< 0.001 respectively). Multiple linear regression analysis showed that serum AGEs level was the only independent factor for Sirt1 in diabetic groups. In conclusion: Serum Sirt1 may be associated with minimal renal impairment in type 2 diabetic nephropathy patients.


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