Bacterial Etiology and Antibiotic Susceptibility Pattern of Diabetic Foot Infections
Paper Details
Bacterial Etiology and Antibiotic Susceptibility Pattern of Diabetic Foot Infections
Abstract
Diabetes mellitus is one of the most prevalent endocrinopathies associated with several complications. These patients are at greater risk for bacterial infection and also have an increased sensitivity for all kinds of infections. In diabetic patients, soft tissue and bone infection of the lower limbs is the so common cause for hospital admission and sometimes leadsto lower-extremity amputation. This study was designed for isolation and characterization of pathogenic strains from the wounds of diabetic foot ulcer and their antibiogram analysis against commonly used antibiotics, a total of fifty samples were collected from the wounds of diabetic patients admitted in Rehman Medical Institute, Peshawar Hayatabad by using appropriate method. The collected samples were inoculated on different types of culture media through pure culturing technique and Standard procedures of gram staining and biochemical tests were carried out for the identification and characterization of bacterial species. Six various types of antibiotics were tested which include Augmentin, Vancomycin, Erythromycin, Cefixime, fosfomycin and Ciprofloxacin against the isolated bacterial species. Eight bacterial species were isolated, among which four were Gram-negative Klebsiella oxytoca, Proteus mirabilis, Yersinia enterocolitica and Providencia and four were Gram-positive Staphylococcus epidermidis, Staphylococcus aureus, Micrococcus kristeniae, Micrococcus mucilaginosus. Amoung these gram positive species M. kristeniae (32.60%) was the most frequently prevalent species in diabetic foot infection. The only antibiotic that was effective against all isolates was Fosfomycin while all other antibiotics used in the present study were only partly or not effective against the isolated species. Only 38%, 25% and 13% of the species were sensitive to Ciprofloxacin, Erythromycin and Cefixime respectively.
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