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Bacteriological profile and antimicrobial resistance patterns of burn wound infections in a tertiary care hospital

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Research Paper 01/03/2021
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Bacteriological profile and antimicrobial resistance patterns of burn wound infections in a tertiary care hospital

Dr. Vishwajith, Dr. K. Anuradha
Int. J. Micro. Myco.12( 3), 1-6, March 2021.
Certificate: IJMM 2021 [Generate Certificate]
Key: AntibiogramBurnsImmunosuppressionStaphylococcus aureus

Abstract

Burns remain a significant public health problem in terms of morbidity, long-term disability and mortality. In India, over 10,00,000 people are moderately or severely burnt every year. Open and large wounds, make burn patients more susceptible to infection. In particular, immunosuppression caused by impaired neutrophil function, cellular and humoral immune system can facilitate multiplication and colonization of burn wounds by different microorganisms. The objective for the study to identify the aerobic bacterial agents responsible for burn wound infection and to study the antibiogram of bacterial isolates. The study was performed in the Department of Microbiology, Mysore Medical College and Research Institute, Mysore, for a period of one year. Wound swabs were collected from the burn wounds, were processed according to standard laboratory procedures to isolate aerobic bacterial pathogens. The isolates were tested for antimicrobial susceptibility and resistance mechanisms by Kirby -Bauer disk diffusion method as per CLSI guidelines. 90 burn patients were included in present study. A total of 114 aerobic bacterial isolates were isolated. Staphylococcus aureus (28.9%) was most common isolate followed by Pseudomonas species (26.3%), Klebsiella species (20.2%), Enterococcus species (7.1%), Enterobacter species, Acinetobacter species and Coagulase negative Staphylococcus (3.5%) each, Escherichia coli and Citrobacter species (2.6%) and Proteus species (1.8%). Antibiogram showed that, Imipenem (86.9%) was most effective drug against Gram negative organisms and vancomycin and linezolid (100%) were effective drugs against Gram positive organisms. It is crucial for every burn unit to determine the specific pattern of burn wound colonization and the antimicrobial resistance pattern. This will enable early treatment with proper empirical systemic antibiotics, thus improving overall infection related morbidity and mortality.

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