Biochemical changes in patients with chronic kidney failure in relation to complete blood count and anemia
Paper Details
Biochemical changes in patients with chronic kidney failure in relation to complete blood count and anemia
Abstract
Erythropoietin is a hormone made by kidney. Kidneys do not secrete erythropoietin when they get damaged and bone marrow makes a smaller number of red blood cells. Red blood cells indices assist in diagnosis to find out cause of anemia and to evaluate patient response to dialysis. The aim of this research was to assess RBCs indices that include MCV, MCHC & MCH in patients with Chronic Renal Failure. A descriptive study conducted about 100 patients from Nishtar Hospital and Medical University, Multan. 2-3ml of blood was drawn from patients of CKD prior to dialysis. Data analyzed by using statistical software such as SPSS 21. Out of 100 patients, 70% were males and 30% were females diagnosed with advanced chronic renal failure. Mean age data was 46.17 years. The mean value of MCV, MCHC & MCH was 76.05, 31.06 & 27.67 respectively. The values of MCV and MCHC were lower than the reference ranges (80-90fL and 33.3-35.5g/dL respectively) but the value of MCH lies within the reference range (27-33pg) in patients with chronic renal failure.
Abdulrahman. 2013. Packed cell volume, Reticulocte count and reticulocyte index among patients with chronic kidney disease in sokoto, Northwestern, Nigeria. Jornal of Medical and Health Sciences 1(3), 1-6.
Celallan W, Aronoff SL, Bolton WK, Hood S. 2004. The prevalence of anemia in patients with chronic kidney diseases . Current Medical Research and Opinion 1, 1501-1510.
Hseih YP, Chang CC, Yang Y. 2017. Mean corpuscular volume and mortality in patients with CKD. Clinical journal of American society of nephrology 12, 237-244.
Kuttykrishnan S, Kalantar-Zadeh K, Cheung AK, Brunelli S, Heagerty PJ, Katz R, Molnar MZ, Nissenson A, Ravel V, Streja E, Himmelfarb J, Mehrotra R. 2015. Predictors of treatment with dialysis modalities in observational studies for comparative effectiveness research. Nephrology Dialysis Transplant 30, 1208-1217.
Nooten FE, Green J, Brown R, Finkelstein FO, Wish J. 2010. Burden of illness for patients with non-dialysis chronic kidney disease and anemia in the United States: review of the literature. Journal of medical Economics 13, 241-256.
Prasad N, Barai S, Gambhir S, Parasar D, Ora M, Gupta A. 2012. Comparison of glomerular filtration rate estimated by plasma clearance method with modification of diet in renal disease prediction equation and Gates method. Indian Journal of Nephrology 22(2), 103.
Suresh M, Singh M, Shravya KG. 2012. Hematological changes in chronic renal failure. International Journal of Scientific Research and Publications 2(9), 1-4.
Tsagalis G. 2011. Renal anemia: a Nephrologist’s view 15 (suppl1 issue), 39-43.
Vashistha T, Streja E, Molnar MZ, Rhee CM, Moradi H, Soohoo M, Kovesdy CP, Kalantar Zadeh K. 2016. Red cell distribution width and mortality in hemodialysis patients. American Journal of Kidney Disease 68, 110-121.
Zhein. 2009. Effect of Dialysis on Erythropoietin and some Hematological Parameters in patients with chronic renal failure. Zanco Journal of Medical Sciences 13(2), 1-8.
Muhammad Naeem, Arsalan Ashraf, Hafiz Muhammad Zeshan Safdar, Mahnoor Qayyum Khan, Shuja Ur Rehman, Rimsha Iqbal, Mohsin Raza, Jabir Ali, Ghafoor Ahmad, 2019. Biochemical changes in patients with chronic kidney failure in relation to complete blood count and anemia. Int. J. Biosci., 15(3), 474-477.
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