Changes in cardiac troponin level in Myocardial infracted patients and its relation with age

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Research Paper 01/08/2016
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Changes in cardiac troponin level in Myocardial infracted patients and its relation with age

Faiz Ullah Khan, Rahool, Bolan Nangyal, Hasnain Nangyal, Muhammad Saleem Khan
Int. J. Biosci.9( 2), 97-103, August 2016.
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Abstract

Myocardial infarction (MI) is one of the most common diseases in all over the world. It is commonly diagnosed by measurements of cardiac enzymes named as cardiac troponin I (cTnI) and cardiac troponin T (cTnT). Raised cardiac troponin levels are considered as the cornerstone in the susceptibility and sensitivity of myocardial infarction. A study was conducted for the evaluation of serum Troponin I (cTnI) levels in different age groups of both gender. There was significant (p<0.05) difference between male and females cTnI, values indicating high mortality rate in males (60.09%) as compared to females (48.57%). However, there was no significant difference (p>0.05) between age groups and cTnl values which shows that susceptibility of MI is not associated with age and some other factors may also responsible for high troponin levels included as high blood pressure, obesity and

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Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE, Chavey WE, Fesmire FM, Hochman JS, Levin TN. 2007. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarc-tion: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infa-rction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulm-onary Rehabilitation and the Society for Academic Emergency Medicine. Journal of the American College of Cardiology 50(7), e1-e157.

Antman E, Bassand J-P, Klein W, Ohman M, Sendon JLL, Rydén L, Simoons M, Tendera M. 2000. Myocardial infarction redefined-a consensus document of the Joint European Society of Cardiology/American College of Cardiology comm-ittee for the redefinition of myocardial infarction: the Joint European Society of Cardiology/American College of Cardiology Committee. Journal of the American College of Cardiology 36(3), 959-969. DOI: 10.1016/s0735-1097(00)00804-4.

Apple FS, Voss E, Lund L, Preese L, Berger CR, Henry TD. 1995. Cardiac troponin, CK-MB and myoglobin for the early detection of acute myocardial infarction and monitoring of reperfusion following thrombolytic therapy. Clinica chimica acta 237(1), 59-66. DOI:  10.1016/0009-8981(95) 06064-k.

Deb P, Sharma S, Hassan K. 2010. Pathophy-siologic mechanisms of acute ischemic stroke: an overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology 17(3), 197-218. DOI: 10.1016/j.pathophys.2009.12.001.

Grossman E, Messerli FH. 1996. Diabetic and hypertensive heart disease. Annals of internal medicine 125(4), 304-310. DOI: 10.7326/0003-4819-125-4-199608150-00009.

Iribarren C, Tolstykh IV, Eisner MD. 2004. Are patients with asthma at increased risk of coronary heart disease? International journal of epidemiology 33(4), 743-748. DOI: 10.1093/ije/dyh081.

Kastrati A, Mehilli J, Neumann F-J, Dotzer F, ten Berg J, Bollwein H, Graf I, Ibrahim M, Pache J, Seyfarth M. 2006. Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. Jama 295(13), 1531-1538.

Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. 2005. Global burden of hypertension: analysis of worldwide data. The lancet 365(9455), 217-223. DOI: 10.1016/s0140-6736(05)70151-3.

Keller T, Zeller T, Ojeda F, Tzikas S, Lillpopp L, Sinning C, Wild P, Genth-Zotz S, Warnholtz A, Giannitsis E. 2011. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. Jama 306(24), 2684-2693. DOI: 10.1001/jama.2011.1896.

Luepker RV, Apple FS, Christenson RH, Crow RS, Fortmann SP, Goff D, Goldberg RJ, Hand MM, Jaffe AS, Julian DG. 2003. Case definitions for acute coronary heart disease in epidemiology and clinical research studies a statement from the AHA council on epidemiology and prevention; AHA statistics committee; World heart federation council on epidemiology and prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute. Circulation 108(20), 2543-2549. DOI: 10.1161/01.cir. 0000100560.46946.ea.

Mac Rae AR, Kavsak PA, Lustig V, Bhargava R, Vandersluis R, Palomaki GE, Yerna M-J, Jaffe AS. 2006. Assessing the requirement for the 6-hour interval between specimens in the American Heart Association Classification of Myocardial Infarction in Epidemiology and Clinical Research Studies. Clinical chemistry 52(5), 812-818. DOI: 10.1373/clinchem.2005.059550.

Mahajan VS, Jarolim P. 2011. How to interpret elevated cardiac troponin levels. Circulation 124(21), 2350-2354.

Manson JE, Willett WC, Stampfer MJ, Colditz GA, Hunter DJ, Hankinson SE, Hennekens CH, Speizer FE. 1995. Body weight and mortality among women. New England journal of medicine 333(11), 677-685. DOI: 10.1097/ 00006205-199511000-00011.

Morrow DA, Cannon CP, Jesse RL, Newby LK, Ravkilde J, Storrow AB, Wu AH, Christenson RH, Apple FS, Francis G. 2007. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Clinical chemistry53(4), 552-574. DOI: 10.1161/circulationaha.107.182882.

Morrow DA, Cannon CP, Rifai N, Frey MJ, Vicari R, Lakkis N, Robertson DH, Hille DA, DeLucca PT, DiBattiste PM. 2001. Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction: results from a randomized trial. Jama 286(19), 2405-2412.

Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. 1992. Long-term morbidity and mortality of overweight adolescents: a follow-up of the Harvard Growth Study of 1922 to 1935. New England journal of medicine 327(19), 1350-1355. DOI: 10.1056/nejm199211053271904.

Reichlin T, Hochholzer W, Bassetti S, Steuer S, Stelzig C, Hartwiger S, Biedert S, Schaub N, Buerge C, Potocki M. 2009. Early diagnosis of myo-cardial infarction with sensitive cardiac troponin assays. New England Journal of Medicine 361(9), 858-867.

Reiter M, Twerenbold R, Reichlin T, Haaf P, Peter F, Meissner J, Hochholzer W, Stelzig C, Freese M, Heinisch C. 2011. Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays. European heart journal 32(11), 1379-1389.

Schanen J, Iribarren C, Shahar E, Punjabi N, Rich S, Sorlie P, Folsom A. 2005. Asthma and incident cardiovascular disease: the Atherosclerosis Risk in Communities Study. Thorax 60(8), 633-638. DOI: 10.1136/thx.2004.026484.

Toren K, Lindholm NB. 1996. Do patients with severe asthma run an increased risk from ischaemic heart disease? International journal of epidemiology 25(3), 617-620. DOI: 10.1093/ije/ 25.3.617.

Upton MT, Rerych SK, Roeback JR, Newman GE, Douglas JM, Wallace AG, Jones RH. 1980. Effect of brief and prolonged exercise on left ventricular function. The American journal of cardiology 45(6), 1154-1160. DOI: 10.1016/0002-9149(80)90473-7.

Wu AH, Apple FS, Gibler WB, Jesse RL, Warshaw MM, Valdes R. 1999. National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases. Clinical chemistry 45(7), 1104-1121.