Paper Details

Changes in histological and liver function assessment of unripe pulp of Carica papaya using diabetic albino rat model

Ahamefula  Sunday Ezekwe, Ify Elekwe, Kelechi Uzoma Osuocha

DOI: http://dx.doi.org/10.12692/ijb/5.2.126-132

Int. J. Biosci. 5(2), 126-132. July, 2014. (PDF)

Abstract:

The present study evaluated the effect of unripe pulp of Carica papaya on alloxan induced diabetic albino rats. Animals weighing (160-200g) were divided into 3 (three) groups of 10 animals each; Group 1(normal control), Group 2(diabetic control) and Group 3(test control). Animals in groups 1 and 2 received normal rat feeds while animals in group 3 were fed with unripe pulp of Carica papaya for a period of 28 days. Body weight and glucose levels were measured on days 0, 7, 14, 21, and day 28. Animals were sacrificed on day 28.  Histological and Liver enzyme assessment were carried out using standard analytical procedures. Improvement in histopathological features was noticed also intake of unripe pulp of Carica papaya reduced significantly serum liver enzymes of the test groups when compared to control (P< 0.05). However, unripe pulp of Carica papaya offers promising antidiabetic, hypolipidemic , organ and cell protective and regenerative effects which may be attributed to some potent bioactive constituents of the pulp.