Welcome to International Network for Natural Sciences | INNSpub

Paper Details

Research Paper | January 1, 2014

VIEWS 1
| Download 1

Circulating adiponectin in obese and non-obese men and its relation with insulin resistance in obese subjects

Khorshidi Davood, Ghanbari Shahpour, Samarikhalaj Hamidreza, Kiani Fatemeh

Key Words:


J. Bio. Env. Sci.4(1), 238-243, January 2014

Certification:

JBES 2014 [Generate Certificate]

Abstract

Decreased adiponectin, an adipose tissue-derived hormone, is associated with obesity and inflammatory diseases. In this study, we aimed 1) to compare serum adiponectin between obese and non-obese men, 2) to determine its relation with insulin resistance in obese subjects. For this purpose, basal concentrations of adiponectin, insulin and glucose were measured after an overnight fast in fifteen non-trained obese or non-obese men matched for age (32 – 39 years). Independent sample T-test was used to compare variables between two groups and Pearson’s correlation coefficient was used to relation between adiponectin and insulin resistance in obese subjects. Based on statistical data, serum adiponectin levels were significantly lower in obese subjects in comparison to non-obese group (p = 0.011). But we did not significant correlation between serum adiponectin with insulin resistance in obese subjects (p = 0.329, r = 0.13). In conclusion, these findings support lower adiponectin in obesity, but it appear to each independently affect glucose.

VIEWS 1

Copyright © 2014
By Authors and International Network for
Natural Sciences (INNSPUB)
http://innspub.net
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Circulating adiponectin in obese and non-obese men and its relation with insulin resistance in obese subjects

Aldhahi W, Hamdy O. 2003. Adipokines, inflammation, and the endothelium in diabetes. Current Diabetes Reports 3(4), 293-8.

Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa Jet. 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 257, 79–83.

Baratta R, Amato S, Degano C, Farina MG, Patanè G, Vigneri R, Frittitta L. 2004. Adiponectin Relationship with Lipid Metabolism Is Independent of Body Fat Mass: Evidence from Both Cross-Sectional and Intervention Studies. Journal of Clinical Endocrinology & Metabolism 89(6), 2665-71.

Calabro P, Yeh ET. 2007. Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ. Sub-cellular biochemistry 42, 63-91.

Chawla A, Saez E, Evans RM. 2000. Don’t know much bile-ology. Cell 103, 1–4.

Conwell LS, Trost SG, Brown WJ. 2004. Indexes of insulin resistance and secretion in obese children and adolescents: a validation study. Diabetes Care 27, 314–19.

Fauntuzi G and Mazzone T. 2007. Adipose Tissue and Adipokines in Health and Disease. Humana Press imprint 5, 31-44.

Fu Y, Luo N, Klein RL, Garvey WT. 2005. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. Journal of Lipid Research 46(7), 1369-79.

Hadaegh F, Harati H, Ghanbarian A, Azizi F. 2006. Association of total cholesterol versus other serum lipid parameters with the short-term prediction of cardiovascular outcomes: Tehran Lipid and Glucose Study. European Journal of Cardiovascular Prevention & Rehabilitation 13, 571-577.

Hu E, Liang P, Spiegelman BM. 1995. AdipoQ is a novel adipose-specific gene dysregulated in obesity. Journal of Biological Chemistry 271, 10697–10703.

Kadowaki T, Yamauchi T. 2005. Adiponectin and adiponectin receptors. Endocrine Reviews 26, 439–451.

Kershaw EE, Flier JS. 2004. Adipose tissue as an endocrine organ. Journal of Clinical Endocrinology & Metabolis 89, 2548–2556.

Lazar MA. 2005. The humoral side of insulin resistance. Nature Medicine 12, 43–44.

Lowell BB. 1999. PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function. Cell 99, 239–242.

Ma K, Cabrero A, Saha P, Kojima H, Li L, Hing-Junn B, Paul A, Chan L. 2002. Increased ß-oxidation but no insulin resistance on glucose intolerance in mice lacking adiponectin. Journal of Biological Chemistry 277, 34658–34661.

Martin M, Palaniappan LP, Kwan AC, Reaven GM. 2008. Ethnic differences in the relationship between adiponectin and insulin sensitivity in South Asian and Caucasian women. Diabetes Care 31, 798– 801.

Meilleur KG, Doumatey A, Huang H, Charles B, Chen G, Zhou J, Shriner D, Adeyemo A, Rotimi C. 2010. Circulating adiponectin is associated with obesity and serum lipids in West Africans. Journal of Clinical Endocrinology & Metabolism 95(7), 3517-21.

Peti A, Juhasz A, Kenyeres P, Varga Z, Seres I, Kovacs GL, Paragh G, Bajnok L. 2010. Relationship of adipokines and non-esterified fatty acid to the insulin resistance in nondiabetic individuals. Journal of Endocrinological Investigation [Epub ahead of print].

Ryo M. 2004. Adiponectin as a biomarker of the metabolic syndrome. Circulation Journal 68, 975– 981.

Staiger K, Stefan N, Staiger H, Brendel MD, Brandhorst D, Bretzel RG. 2005. Journal of Clinical Endocrinology & Metabolism 90(12), 6707-13.

Steppan CM. 2001. The hormone resistin links obesity to diabetes. Nature 409, 307–312.

Tai ES, Tan ML, Stevens RD, Low YL, Muehlbauer MJ, Goh DL. 2010. Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia 53(4), 757-67.

Takashi K, Toshimasa Y, Naoto K, Kazuo H, Kohjiro U, Kazuyuki T. 2006. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Journal of Clinical Investigation 116, 1784–1792.

Tschritter O, Fritsche A, Thamer C, Haap M, Shirkavand F, Rahe S, Staiger H,Maerker E, HaringH, StumvollM. 2003. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 52, 239–243.

Weyer C. 2001. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperansulinemia. Journal of Clinical Endocrinology & Metabolism 86, 1930-1935.

Yamamoto Y, Hirose H, Saito I, Nishikai K, Saruta T. 2004. Adiponectin, an adipocyte-derived protein, predicts future insulin-resistance: two-year follow-up study in Japanese population. Journal of Clinical Endocrinology & Metabolism 89, 87–90.

Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S. 2003. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. Journal of Biological Chemistry 278, 2461–2468.

Yang Q. 2005. Serum retinal binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436, 356–362.

Yatagai T. 2003. Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. Metabolism 52, 1274–1278.

Yukihiro Y, Hiroshi H, Ikuo S, Motowo T, Matsuo T, Koichi M. 2002. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clinical Science 103, 137–142.

SUBMIT MANUSCRIPT

Style Switcher

Select Layout
Chose Color
Chose Pattren
Chose Background